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Establishment of Clinical Prediction Model Based on the Study of Risk Factors of Stroke in Patients With Type 2 Diabetes Mellitus
Conclusion: This study established a model predicting risk of stroke for T2DM patients through a community-based survey.
Source: Frontiers in Endocrinology - August 24, 2020 Category: Endocrinology Source Type: research

Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: analysis of ALTITUDE trial
Conclusions/interpretationWe identified three questions from the MNSI that provide additional prognostic information for individuals with type 2 diabetes and CKD and/or CVD. If externally validated, these questions may be integrated into the clinical history to augment prediction of CV events in high-risk individuals with type 2 diabetes.
Source: Diabetologia - November 3, 2017 Category: Endocrinology Source Type: research

Exercise Training Improves but Does Not Normalize Left Ventricular Systolic and Diastolic Function in Adolescents With Type 1 Diabetes
CONCLUSIONS These data demonstrate that in adolescents, the impairment in left ventricular function seen with type 1 diabetes can be improved, although not normalized, with regular intense physical activity. Importantly, diastolic dysfunction, a common mechanism causing heart failure in older subjects with diabetes, appears to be partially reversible in this age group.
Source: Diabetes Care - August 22, 2017 Category: Endocrinology Authors: Gusso, S.; Pinto, T.; Baldi, J. C.; Derraik, J. G. B.; Cutfield, W. S.; Hornung, T.; Hofman, P. L. Tags: Cardiovascular and Metabolic Risk Source Type: research

High intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trial
ConclusionFollowing high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.Trial registrationISRCTN78698481. Registered 23 January 2013, retrospectively registered.
Source: Acta Diabetologica - November 1, 2018 Category: Endocrinology Source Type: research

A model of poorly controlled type 1 diabetes mellitus and its treatment with aerobic exercise training.
CONCLUSIONS: Together, this study demonstrates that despite moderate hyperglycaemia, the combined role of a ten-week exercise training program coupled with insulin therapy is able to alleviate many of the well-known complications associated with diabetes progression. PMID: 23522732 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - March 19, 2013 Category: Endocrinology Authors: Melling CW, Grisé KN, Hasilo CP, Fier B, Milne KJ, Karmazyn M, Noble EG Tags: Diabetes Metab Source Type: research

High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2 diabetes: a randomised controlled trial
Conclusions/interpretation This is the first study to demonstrate improvements in cardiac structure and function, along with the greatest reduction in liver fat, to be recorded following an exercise intervention in type 2 diabetes. HIIT should be considered by clinical care teams as a therapy to improve cardiometabolic risk in patients with type 2 diabetes. Trial registration: www.isrctn.com 78698481 Funding: Medical Research Council.
Source: Diabetologia - September 9, 2015 Category: Endocrinology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research