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Trends in the Incidence and Risk Factors of Pregnancy-Associated Stroke
The objective of this review is to summarize studies on time trends of PAS in relation to trends in the prevalence of stroke risk factors in pregnant women. Seven retrospective national healthcare register-based cohort studies from the US, Canada, UK, Sweden, and Finland were identified. Five studies from the US, Canada, and Finland reported an increasing trend of PAS. Potential biases include more sensitive diagnostics and improved stroke awareness among pregnant women and professionals toward the end of the study period. However, the concurrent increase in the prevalence of several stroke risk factors among pregnant wome...
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research

Inflammatory Biomarkers and Intracranial Hemorrhage after Endovascular Thrombectomy
CONCLUSION: Higher neutrophil counts, low WBC counts, low lymphocyte counts, and low platelet to lymphoycyte ratio were baseline serology biomarkers that were associated with post-EVT hemorrhage. Our findings, particularly the association of diabetes mellitus and high neutrophil, support experimental data on the role of thromboinflammation in hemorrhagic transformation of large vessel occlusions.PMID:34548113 | DOI:10.1017/cjn.2021.197
Source: The Canadian Journal of Neurological Sciences - September 22, 2021 Category: Neurology Authors: Jose Danilo Bengzon Diestro Carmen Parra-Farinas Michael Balas Zsolt Zador Noora Almusalam Adam A Dmytriw Phavalan Rajendram Rebecca Phillips Abdullah Alqabbani Emmad Qazi Yangmei Li Walter Montanera Dipanka Sarma Thomas R Marotta Aditya Bharatha Julian S Source Type: research

Thrombolysis Outcomes in Patients with Diabetes and Previous Stroke: A Meta-Analysis.
PMID: 32234105 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - March 31, 2020 Category: Neurology Authors: Pajo AT, Diestro JDB, Espiritu AI, Dmytriw AA, Enriquez-Marulanda A, Sarmiento RJC, Bagnas MAC, Spears J, San Jose MCZ Tags: Can J Neurol Sci Source Type: research

Associations of Anemia With Outcomes in Patients With Spontaneous Intracerebral Hemorrhage: A Meta-Analysis
Conclusions: Anemia on admission was associated with higher mortality and an increased risk of poor outcome in patients with ICH. However, the results were limited by the high heterogeneity of included studies. Prospective, multi-center or population-based, large sample cohort studies are needed in the future. Introduction Intracerebral hemorrhage (ICH) is the second most common cause of stroke and a highly lethal disease (1), which still lacks effective therapeutic interventions (2, 3). Although age, baseline ICH volume and neurological status on admission are well-known predictors of outcome of ICH (4), none of t...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Characterizing the Penumbras of White Matter Hyperintensities and Their Associations With Cognitive Function in Patients With Subcortical Vascular Mild Cognitive Impairment
Conclusion In this study, reduced CBF and FA and increased MD in the inner NAWM layers for both PVWMH and DWMH suggested extensive WM alterations beyond the visible WM lesions commonly observed on clinical MRI of svMCI subjects. CBF penumbras cover more extensive WM at risk than DTI penumbras, suggesting the likelihood that compromised CBF precedes white matter integrity changes, and CBF penumbras may be a potential target for the prevention of further microstructural white matter damage. The imaging parameters investigated, however, did not correlate to cognition. Author Contributions YZ, QX, and XG conceived and desig...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Stroke and Coronary Artery Disease Are Associated With Parkinson's Disease.
CONCLUSIONS: Our study suggested that stroke and CAD are associated with PD in two Chinese population-based cohorts, indicating a probable vascular component in the pathogenesis of PD. PMID: 30001757 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - July 13, 2018 Category: Neurology Authors: Li Q, Wang C, Tang H, Chen S, Ma J Tags: Can J Neurol Sci Source Type: research

Sex Differences in Outcomes after Stroke in Patients with Diabetes in Ontario, Canada
Outcomes after stroke in those with diabetes are not well characterized, especially by sex and age. We sought to calculate the sex- and age-specific risk of cardiovascular outcomes after ischemic stroke among those with diabetes.
Source: Journal of Stroke and Cerebrovascular Diseases - September 13, 2017 Category: Neurology Authors: Mandip S. Dhamoon, John W. Liang, Limei Zhou, Melissa Stamplecoski, Moira K. Kapral, Baiju R. Shah Source Type: research

Prevalence of Fabry Disease and Outcomes in Young Canadian Patients With Cryptogenic Ischemic Cerebrovascular Events Clinical Sciences
Conclusions—In this Canadian cohort of patients with cryptogenic IS or TIA, the prevalence of Fabry was 0.3% if p.R118C variant is considered as pathogenic. This suggests that more cost-effective methods should be applied for diagnosis of Fabry rather than systematic genetic screening in this population. Overall, cryptogenic IS in young adults is associated with favorable outcomes.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Sylvain Lanthier, Gustavo Saposnik, Gerald Lebovic, Karen Pope, Daniel Selchen, David F. Moore, on behalf of the Canadian Fabry Stroke Screening Initiative Study Group Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA), Vascular Disease Original Contributions Source Type: research