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Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association
Circulation. 2022 Jan 10:CIR0000000000001040. doi: 10.1161/CIR.0000000000001040. Online ahead of print.ABSTRACTCardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in cardiovascular events. The 2015 American Heart Association and American Diabetes Association scientific statement, "Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence," highlighted the importance of modifying various risk factors resp...
Source: Circulation - January 10, 2022 Category: Cardiology Authors: Joshua J Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L Bhatt Deborah A Chyun Katherine E Di Palo Sherita H Golden Laurence S Sperling American Heart Association Diabetes Committee of the Council on Lifestyle and Cardiometabolic Health; Co Source Type: research

Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research

Bending the Curve in Cardiovascular Disease Mortality: Bethesda + 40 and Beyond
This report summarizes the relevant research, policy, and practice opportunities discussed at the symposium.PMID:33617315 | DOI:10.1161/CIRCULATIONAHA.120.046501
Source: Circulation - February 22, 2021 Category: Cardiology Authors: David Calvin Goff Sadiya Sana Khan Donald Lloyd-Jones Donna K Arnett Mercedes R Carnethon Darwin R Labarthe Matthew Shane Loop Russell V Luepker Michael V McConnell George A Mensah Mahasin S Mujahid Martin Enrique O'Flaherty Dorairaj Prabhakaran V éroniq Source Type: research

Coronary artery calcium score to guide hypertension therapy!
Hypertension is the most prevalent non-communicable disease, estimated to affect 1.13 billion individuals nowadays. It is the leading preventable cause of mortality worldwide and a major risk factor for coronary artery disease, heart failure, stroke and chronic renal diseases in developed and developing countries.1,2. Worldwide, the aging population, decreased fitness and obesity epidemic have contributed to the increased prevalence of hypertension3. Given that, it poses a significant health and economic challenge to both developed and developing countries.
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Ahmed Aljizeeri, Ahmed Alsaileek, Mouaz H. Al-Mallah Tags: Editorial Source Type: research

Atrial Fibrillation in Heart Failure: a Therapeutic Challenge of Our Times.
Authors: Batul SA, Gopinathannair R Abstract Atrial fibrillation (AF) and heart failure (HF) are growing cardiovascular disease epidemics worldwide. There has been an exponential increase in the prevalence of AF and HF correlating with an increased burden of cardiac risk factors and improved survival rates in patients with structural heart disease. AF is associated with adverse prognostic outcomes in HF and is most evident in mild-to-moderate left ventricular (LV) dysfunction where the loss of "atrial kick" translates into poorer quality of life and increased mortality. In the absence of underlying structural heart...
Source: Korean Circulation Journal - September 29, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

Bowel movement frequency and cardiovascular mortality, a matter of fibers and oxidative stress?
To the Editor, Hippocrates, the father of western medicine, believed that all disease begins in the gut. Today, the global obesity epidemic, resulting in serious diet-related diseases, including cardiovascular disease, stroke, hypertension, diabetes mellitus type 2 and certain forms of cancer, including colorectal cancer, reveals that his view is still relevant. The relation between diet and health and the resulting potential for disease prevention has increasingly been emphasized in health promotion messages over the last thirty years [1 –5].
Source: Atherosclerosis - August 20, 2016 Category: Cardiology Authors: Alphons J.M. Vermorken, Yali Cui, Robbert Kleerebezem, Emmanuel Andr ès Tags: Correspondence Source Type: research

Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating Obesity
This article reviews recent literature in the field of Obesity Medicine and highlights important findings from clinical trials. Future directions in the pharmacologic management of obesity are presented along with new diabetes medications that promote weight loss and reduce cardiovascular mortality.
Source: Current Atherosclerosis Reports - May 14, 2016 Category: Cardiology Source Type: research

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease.
Abstract Atherosclerosis is a leading cause of vascular disease worldwide. Its major clinical manifestations include ischemic heart disease, ischemic stroke, and peripheral arterial disease. In high-income countries, there have been dramatic declines in the incidence and mortality from ischemic heart disease and ischemic stroke since the middle of the 20th century. For example, in the United Kingdom, the probability of death from vascular disease in middle-aged men (35-69 years) has decreased from 22% in 1950 to 6% in 2010. Most low- and middle-income countries have also reported declines in mortality from stroke ...
Source: Circulation Research - February 19, 2016 Category: Cardiology Authors: Herrington W, Lacey B, Sherliker P, Armitage J, Lewington S Tags: Circ Res Source Type: research

Endocannabinoids and cardiovascular prevention: real progress?
Authors: Nodari S, Manerba A, Metra M, Dei Cas L Abstract The prevalence of obesity continues to increase and represents one of the principal causes of cardiovascular morbidity and mortality. After the discovery of a specific receptor of the psychoactive principle of marijuana, the cannabinoid receptors and their endogenous ligands, several studies have demonstrated the role of this system in the control of food intake and energy balance and its overactivity in obesity. Recent studies with the CB1 receptor antagonist rimonabant have demonstrated favorable effects such as a reduction in body weight and waist circumf...
Source: Heart International - November 28, 2015 Category: Cardiology Tags: Heart Int Source Type: research

The metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

The Metabolic Syndrome, Atrial Fibrillation and Stroke: Tackling An Emerging Epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of metabolic syndrome. Metabolic syndrome describes an association between diabetes, hypertension, obesity, dyslipidaemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory YH Lip Tags: CRV Source Type: research

Metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

Global Trend in Overweight and Obesity and Its Association With Cardiovascular Disease Incidence.
Abstract Although the global prevalence of both the overweight and obese is on the rise, there are variations among regions or countries, and sexes. Approximately half or more than half of the population are overweight/obese defined as body mass index ≥25 kg/m(2)in the Americas (61.1%), Europe (54.8%), and Eastern Mediterranean (46.0%) according to the World Health Organization, while a much lower prevalence is observed in Africa (26.9%), South-East Asia (13.7%), and the Western Pacific (25.4%). Females are more likely to be overweight/obese in the Eastern Mediterranean, Africa, South-East Asia and the majority ...
Source: Circulation Journal - November 11, 2014 Category: Cardiology Authors: Yatsuya H, Li Y, Hilawe EH, Ota A, Wang C, Chiang C, Zhang Y, Uemura M, Osako A, Ozaki Y, Aoyama A Tags: Circ J Source Type: research

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