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Total 2966 results found since Jan 2013.

7 Myths About Cholesterol, Debunked
You may not recall every lab value from your last physical, but you probably remember one: Your cholesterol level. If it’s higher than ideal, you’re not alone. According to the U.S. Centers for Disease Control and Prevention, between 2015 and 2018, almost 12% of U.S. adults ages 20 and up had high total cholesterol, defined as above 240 mg/dL. The type that physicians mostly worry about is LDL (or “bad”) cholesterol, which is one component of that total. Why do doctors care so much about cholesterol? First, “it predicts risk,” says Dr. Jeffrey Berger, a cardiologist and director of the C...
Source: TIME: Health - June 19, 2023 Category: Consumer Health News Authors: Katherine Hobson Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

ApoC-III Proteoforms, Plasma Lipids, and Cardiovascular Risk in MESA
CONCLUSIONS: Our data indicate differences in clinical and demographic relationships of apoC-III proteoforms, and highlight the importance of apoC-III proteoform composition in predicting future lipid patterns and cardiovascular disease risk.PMID:37317850 | DOI:10.1161/ATVBAHA.123.319035
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 15, 2023 Category: Cardiology Authors: Shripad Sinari Juraj Koska Yueming Hu Jeremy Furtado Majken K Jensen Matthew J Budoff Dobrin Nedelkov Robyn L McClelland Dean Billheimer Peter Reaven Source Type: research

FTO alleviates cerebral ischemia/reperfusion-induced neuroinflammation by decreasing cGAS mRNA stability in an m6A-dependent manner
In conclusion, this study deepens our understanding on the relationship of m6A modification and microglia-mediated inflammation in cerebral I/R injury, and insights a novel m6A-based therapeutic for inhibiting inflammatory response against ischemic stroke.PMID:37321527 | DOI:10.1016/j.cellsig.2023.110751
Source: Cellular Signalling - June 15, 2023 Category: Cytology Authors: Zhiyong Yu Linbo Zheng Yan Geng Yuting Zhang Yupeng Wang Guoxing You Mingsheng Cai Meili Li Xiao Cheng Jie Zan Source Type: research

Association of polycystic ovary syndrome with cardiovascular disease among US female hospitalizations
CONCLUSIONS: PCOS is associated with CVD events and the association is mediated by obesity and metabolic syndrome conditions, particularly among hospitalized women less than or equal to age 40 years in the US.PMID:37307574 | DOI:10.1093/ejendo/lvad067
Source: European Journal of Endocrinology - June 12, 2023 Category: Endocrinology Authors: Alok Kumar Dwivedi Deepanjali Vishwakarma Pallavi Dubey Sireesha Reddy Source Type: research

Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research

Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating fat mass and obesity ‐associated—N6‐methyladenosine—acyl‐CoA synthetase long‐chain family member 4 axis
Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. Astragaloside IV (As-IV) was a promising bioactive constituent in the treatment of IS. In our study, As-IV promoted the transcription of fat mass and obesity-associated (Fto) by upregulating activating transcription factor 3(Atf3), resulting in a decrease of long-chain acyl-CoA synthetase-4 (Acsl4) N6-methyladenosine (m6A) levels, thus improving neuronal injury in IS by inhibiting ferroptosis. These findings provided a better understanding of the molecular mechanisms underlying the neuroprotective effects of As-IV and led to novel t...
Source: Journal of Neurochemistry - June 10, 2023 Category: Neuroscience Authors: Zhenglong Jin, Wenying Gao, Fu Guo, Shaojun Liao, Mingzhe Hu, Tao Yu, Shangzhen Yu, Qing Shi Tags: ORIGINAL ARTICLE Source Type: research

DOACs use in extreme body-weighted patients: results from the prospective START-register
ConclusionsDOACs seem to be effective and safe also for the treatment of patients with extreme body weights, both underweight and overweight. Further prospective studies are needed to support these findings.
Source: Internal and Emergency Medicine - June 10, 2023 Category: Emergency Medicine Source Type: research

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