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Condition: Obesity
Nutrition: Diets
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Total 82 results found since Jan 2013.
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress
Biochem Pharmacol. 2022 Aug 7:115203. doi: 10.1016/j.bcp.2022.115203. Online ahead of print.ABSTRACTResolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. In mouse primary hepatocytes, RD3 ...
Source: Biochemical Pharmacology - August 10, 2022 Category: Drugs & Pharmacology Authors: Heeseung Oh Wonjun Cho A M Abd El-Aty Cemil Bayram Ji Hoon Jeong Tae Woo Jung Source Type: research
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
CONCLUSION: LBP seems to exert a negative feedback on ERα-mediated estrogen action, impacting on genes involved in thermogenesis. The known decreased estrogen action and negative effects of metabolic endotoxemia may be targeted through LBP downregulation.PMID:35643066 | DOI:10.1016/j.biopha.2022.113156
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 1, 2022 Category: Drugs & Pharmacology Authors: Ferran Comas Ramon D íaz-Trelles Aleix Gavald à-Navarro Edward Milbank Nathalia Dragano Samantha Mor ón-Ros Rajesh Mukthavaram Jessica Latorre Francisco Ortega Maria Arnoriaga-Rodriguez N úria Oliveras-Cañellas Wifredo Ricart Priya P Karmali Kiyoshi Source Type: research
Adapalene induces adipose browning through the RAR β-p38 MAPK-ATF2 pathway
This study identifies new actions of AD as an adipose browning agent and demonstrates that RARβ activation followed by increased phosphorylation of p38 MAPK and ATF2 appears to be a key mechanism of AD action.PMID:35608792 | DOI:10.1007/s12272-022-01384-4
Source: Archives of Pharmacal Research - May 24, 2022 Category: Drugs & Pharmacology Authors: Na Hyun Lee Mi Jin Choi Hana Yu Jea Il Kim Hyae Gyeong Cheon Source Type: research
A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction
Biomaterials. 2022 Apr 28;285:121541. doi: 10.1016/j.biomaterials.2022.121541. Online ahead of print.ABSTRACTObesity is the major risk factor for metabolic diseases such as fatty liver, hyperlipidemia and insulin resistance. Beige fat has been recognized as a therapeutic target considering its great potential to burn energy. Since the evolutionary discovery of RNA interference and its utilization for gene knockdown in mammalian cells, a remarkable progress has been achieved in siRNA-based therapeutics. However, efficient delivery of siRNA into adipose tissues or differentiated adipocytes is challenging due to high lipid co...
Source: Biomaterials - May 9, 2022 Category: Materials Science Authors: Jin Qiu Qianqian Fan Sainan Xu Dongmei Wang Juntong Chen Sainan Wang Tianhui Hu Xinran Ma Yiyun Cheng Lingyan Xu Source Type: research
Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis
CONCLUSIONS: The testicular zinc transporter ZIP12 expression levels especially in spermatogonia and spermatozoa are higher than in other tissues. ZIP12 may play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis which help counteract declines in male fertility.PMID:35065654 | PMC:PMC8783530 | DOI:10.1186/s12958-022-00893-7
Source: Reproductive Biology - January 23, 2022 Category: Reproduction Medicine Authors: Xinye Zhu Chengxuan Yu Wangshu Wu Lei Shi Chenyi Jiang Li Wang Zhide Ding Yue Liu Source Type: research
MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice
Biomaterials. 2021 Oct 11;278:121183. doi: 10.1016/j.biomaterials.2021.121183. Online ahead of print.ABSTRACTThe changes of small intestinal homeostasis have been recognized to contribute essentially to the obese development. However, the core small intestinal regulator which mediates over-nutrient impacts on the homeostasis of the small intestines remains elusive. Here, we identify the MMP-12 as such a responsive factor in mouse small intestines. Taking advantages of the nano delivery system, we demonstrate that small intestine-specific MMP-12 knockdown alleviates high-fat diet feeding-induced metabolic disorders and impr...
Source: Biomaterials - October 15, 2021 Category: Materials Science Authors: Mingming Song Shiyao Zhang Zixuan Tao Jianning Li Yujie Shi Yonghong Xiong Wenxiang Zhang Chang Liu Siyu Chen Source Type: research
MiR-124 Prevents the Microglial Proinflammatory Response by Inhibiting the Activities of TLR4 and Downstream NLRP3 in Palmitic Acid-Treated BV2 Cells
AbstractNeuroinflammation is a mechanism by which obesity or a high-fat diet leads to cognitive impairment. MiR-124, a highly expressed microRNA in the brain, can alleviate neuroinflammation by regulating microglial activation, but its mechanism is unclear. The aim of the study was to explore whether miR-124 exerted this effect through TLR4/MyD88/NF- κB p65/NLRP3 signaling in palmitic acid-treated BV2 cells. Prepared BV2 cells were treated with palmitic acid to establish an in vitro model of a high-fat diet. An miR-124 mimic and inhibitor were adopted to upregulate and downregulate the expression of miR-124, respectively....
Source: Journal of Molecular Neuroscience - October 15, 2021 Category: Neuroscience Source Type: research
High-fat diet exacerbated BDE-209-induced hepatocyte apoptosis via intensifying the transfer of Ca < sup > 2+ < /sup > from endoplasmic reticulum to mitochondria
This study aimed to evaluate the hepatotoxicity of BDE-209 in lean and high-fat diet (HFD)-treated obese mice and elucidate the underlying mechanisms. Firstly, the increasing levels of triacylglycerol and proinflammatory factors in the liver and ALT and AST in serum demonstrated the hepatic damage caused by BDE-209 and further exacerbated by HFD. Tunel image revealed that BDE-209 induced more severe hepatocyte apoptosis with the assistant of HFD. Next, the mechanism analysis showed that the pro-apoptotic action of BDE-209 was in an endoplasmic reticulum (ER)/Ca2+ flux/mitochondria-dependent manner, concluded from the impai...
Source: Environmental Pollution - October 8, 2021 Category: Environmental Health Authors: Sunni Chen Siyan Che Shiqi Li Jin Wan Zheng Ruan Source Type: research
Therapeutic DNA vaccine encoding CEMIP (KIAA1199) ameliorates kidney fibrosis in obesity through inhibiting the Wnt/ β-catenin pathway
CONCLUSION: DNA vaccine targeting CEMIP/Wnt1/β-catenin pathway plays a novel strategy in nephropathy.GENERAL SIGNIFICANCE: Immune therapy might provide a new therapeutic option on nephropathy of obesity.PMID:34582938 | DOI:10.1016/j.bbagen.2021.130019
Source: Biochimica et Biophysica Acta - September 28, 2021 Category: Biochemistry Authors: Chao-Hung Chen Guan-Ming Ke Pi-Chen Lin Kun-Der Lin Source Type: research
