Filtered By:
Specialty: Molecular Biology
Condition: Cholesterol
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1859 results found since Jan 2013.
Interrelationship of hemoglobin A1c level lipid profile, uric acid, C-reactive protein levels and age in a large hospital database
CONCLUSION: At population level, HbA1c levels can be estimated almost exactly based on lipid profile, CRP and uric acid levels in female patients between 20 and 70 years.PMID:37722548 | DOI:10.1016/j.mcp.2023.101933
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Dlovan Ali Jalal Barna V ásárhelyi B éla Blaha Zolt án Tóth Tam ás Géza Szabó B éla Gyarmati Source Type: research
Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research
Thymoquinone attenuates olanzapine-induced metabolic disorders in rats
CONCLUSIONS: The present study demonstrates the effectiveness of TQ on OLZ-induced metabolic abnormalities related to its antioxidant activity and regulation of glucose homeostasis and lipid metabolism.PMID:37707771 | DOI:10.1007/s11033-023-08726-5
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Farima Kaviani Bibi Marjan Razavi Mahdieh Sadat Mohsenzadeh Maryam Rameshrad Hossein Hosseinzadeh Source Type: research
Chemical Synthesis and Biochemical Properties of Cholestane-5 α,6β-diol-3-sulfonate, A Non-hydrolysable Analogue of cholestane-5α,6β-diol-3β-sulfate
J Steroid Biochem Mol Biol. 2023 Sep 6:106396. doi: 10.1016/j.jsbmb.2023.106396. Online ahead of print.ABSTRACTCholestane-3β,5α,6β-triol (CT) is a primary metabolite of 5,6-epoxycholesterols (5,6-EC) that is catalyzed by the cholesterol-5,6-epoxide hydrolase (ChEH). CT is a well-known biomarker for Niemann-Pick disease type C (NP-C), a progressive inherited neurodegenerative disease. On the other hand, CT is known to be metabolized by the 11β-hydroxysteroid-dehydrogenase of type 2 (11β-HSD2) into a tumor promoter named oncosterone that stimulates the growth of breast cancer tumors. Sulfation is a major metabolic trans...
Source: Mol Biol Cell - September 8, 2023 Category: Molecular Biology Authors: Philippe de M édina Silia Ayadi R égis Soulès Bruno Payre Sandrine Rup-Jacques Sandrine Silvente-Poirot Mohammad Samadi Marc Poirot Source Type: research
Immunometabolic impact of pancreastatin inhibitor PSTi8 in MCD induced mouse model of oxidative stress and steatohepatitis
Cytokine. 2023 Sep 4;171:156354. doi: 10.1016/j.cyto.2023.156354. Online ahead of print.ABSTRACTAIM: Pancreastatin, a dysglycemic hormone that encourages inflammation and steatosis in a variety of metabolic disorder animal models. The purpose of this study is to determine the effect of the pancreastatin inhibitor PSTi8 on immunometabolic changes in the liver of MCD-induced NASH mice.MAIN METHODS: Methionine and choline-deficient (MCD) diet was used for the development of NASH. Liver enzymes like SGOT, SGPT, and ALP and lipid profiles were also performed in the serum. Further, immunophenotyping study was performed in the li...
Source: Cytokine - September 6, 2023 Category: Molecular Biology Authors: Umesh K Goand Inklisan Patel Saurabh Verma Shubhi Yadav Debalina Maity Naveen Singh Sachin Vishwakarma Shivam Rathaur Richa Garg Jiaur R Gayen Source Type: research
Metabolic characteristics of voriconazole - Induced liver injury in rats
This study investigated the changes of plasma metabolic profiles in a rat model of VOR - induced liver injury by non - targeted metabolomics. Correlation analysis was performed between differentially expressed metabolites and plasma liver function indexes. The metabolites with strong correlation were determined for their predictive performance for liver injury using receiver operating characteristic (ROC) curve analysis. Potential biomarkers were then screened combined with liver pathological scores. Finally, the expression level of genes that involved in lipid metabolism were determined in rat liver to verify the mechanis...
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Qian Du Mengmeng Teng Luting Yang Chao Meng Yulan Qiu Chuhui Wang Jiaojiao Chen Taotao Wang Siying Chen Yu Luo Jinyao Sun Yalin Dong Source Type: research
Microbial oil, alone or paired with β-glucans, can control hypercholesterolemia in a zebrafish model
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Aug 30:159383. doi: 10.1016/j.bbalip.2023.159383. Online ahead of print.ABSTRACTDyslipidemia is often associated with unhealthy dietary habits, and many mammalian studies have explored the mode of action of certain bioactive compounds such as β-glucans and n-3 PUFAs to understand their potential to normalize the lipid metabolism. There are only a few investigations of their combined effect on hypercholesterolemia by adopting omics approaches. Zebrafish (Danio rerio) was used as a model organism to reveal the efficacy of Schizochytrium oil and β-glucans (from Euglena gracili...
Source: Mol Biol Cell - September 1, 2023 Category: Molecular Biology Authors: Adnan H Gora Saima Rehman Jorge Dias Jorge M O Fernandes P ål A Olsvik Mette S ørensen Viswanath Kiron Source Type: research
Functional significance of cholesterol metabolism in cancer: from threat to treatment
Exp Mol Med. 2023 Sep 1. doi: 10.1038/s12276-023-01079-w. Online ahead of print.ABSTRACTCholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities. Recently, increasing evidence has indicated that cholesterol is a major determinant by modulating cell signaling events governing the hallmarks of cancer. Numerous studies have shown the functional significance of cholesterol metabolism in tumorigenesis, cancer progression and metastasis through its regulatory effects on the immune resp...
Source: Molecular Medicine - August 31, 2023 Category: Molecular Biology Authors: Mingming Xiao Jin Xu Wei Wang Bo Zhang Jiang Liu Jialin Li Hang Xu Yingjun Zhao Xianjun Yu Si Shi Source Type: research
Differential Expression of Subsets of Genes Related to HDL Metabolism and Atherogenesis in the Peripheral Blood in Coronary Artery Disease
Curr Issues Mol Biol. 2023 Aug 16;45(8):6823-6841. doi: 10.3390/cimb45080431.ABSTRACTDifferential expression of genes (DEGs) in coronary artery disease (CAD) and the association between transcript level and high-density lipoprotein cholesterol (HDL-C) were studied with 76 male patients with CAD and 63 control patients. The transcript level of genes related to HDL metabolism (24 genes) and atherosclerosis-prone (41 genes) in RNA isolated from peripheral blood mononuclear cells was measured by real-time RT-PCR. Twenty-eight DEGs were identified. The expression of cholesterol transporters, ALB, APOA1, and LCAT was down-regula...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Alexander D Dergunov Elena V Nosova Alexandra V Rozhkova Margarita A Vinogradina Veronika B Baserova Mikhail A Popov Svetlana A Limborska Liudmila V Dergunova Source Type: research
