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Total 33 results found since Jan 2013.

Challenges in Conducting Therapeutic Trials in Pregnancy: Emphasizing Recent Lessons Learned
This article reviews the history of research guidelines in pregnancy and illustrates ongoing challenges, as seen in the development of vaccines and therapies during the coronavirus disease 2019 pandemic and investigation of statins for preeclampsia prevention. It explores new approaches that may be used to improve therapeutic research in pregnancy. A major cultural shift is needed to balance potential maternal and/or fetal risks with potential benefits from participation in research, as well as harm from withholding treatment or providing one that is not evidence-based. Finally, it is important to honor maternal autonomy i...
Source: The Journal of Clinical Pharmacology - June 15, 2023 Category: Drugs & Pharmacology Authors: Tracy Caroline Bank Catherine S Stika Raman Venkataramanan Christine Field Maged M Costantine Source Type: research

Cholesterol, Coronary Calcification, and Cardiovascular Prevention: Lessons We Can Learn From the Western Denmark Heart Registry
Circulation. 2023 Apr 4;147(14):1064-1066. doi: 10.1161/CIRCULATIONAHA.123.063658. Epub 2023 Apr 3.NO ABSTRACTPMID:37011071 | DOI:10.1161/CIRCULATIONAHA.123.063658
Source: Circulation - April 3, 2023 Category: Cardiology Authors: Elie Akl Allan D Sniderman Source Type: research

What ’ s On Your Plate? Culinary Medicine as an Innovative Nutrition Education Model
On this episode of the Academic Medicine Podcast, guests Courtney Newman and Jaclyn Albin, MD, join host Toni Gallo to discuss culinary medicine and its role in teaching nutrition, nutrition counseling, and hands-on cooking skills to medical students. The conversation also covers how culinary medicine programs build connections and community and improve the well-being of students, faculty, and patients. This episode is now available through Apple Podcasts, Spotify, and anywhere else podcasts are available. A transcript is below. Read the article discussed in this episode: Newman C, Yan J, Me...
Source: Academic Medicine Blog - February 20, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast culinary medicine medical education nutrition patient care Source Type: blogs

Impact of lipid lowering on coronary atherosclerosis moving from the lumen to the artery wall
Atherosclerosis. 2023 Jan 20;367:8-14. doi: 10.1016/j.atherosclerosis.2023.01.017. Online ahead of print.ABSTRACTRandomized clinical trials have demonstrated that increasingly intensive lowering of low-density lipoprotein cholesterol (LDL-C) reduces the rate of cardiovascular events in the primary and secondary prevention setting. Integration of serial coronary imaging within clinical trials has enabled evaluation of medical therapies on the natural history of coronary disease. These studies have extended from early investigation of coronary obstruction with angiography to more contemporary evaluation of plaque burden and ...
Source: Atherosclerosis - January 30, 2023 Category: Cardiology Authors: Giuseppe Di Giovanni Yu Kataoka Kristen Bubb Adam J Nelson Stephen J Nicholls Source Type: research

A rare case of renal involvement in Lecithin-Cholesterol Acyltransferase (LCAT) deficiency: lessons for the clinical nephrologist
J Nephrol. 2022 Sep 26. doi: 10.1007/s40620-022-01459-x. Online ahead of print.NO ABSTRACTPMID:36156199 | DOI:10.1007/s40620-022-01459-x
Source: Journal of Nephrology - September 26, 2022 Category: Urology & Nephrology Authors: Ashutosh Rath Zafirah Zahir Manoj Jain Manas Ranjan Patel Source Type: research

Role of thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans
Cardiovasc Res. 2022 Aug 10:cvac131. doi: 10.1093/cvr/cvac131. Online ahead of print.ABSTRACTBrown adipocytes within brown adipose tissue (BAT) and beige adipocytes within white adipose tissue dissipate nutritional energy as heat. Studies in mice have shown that activation of thermogenesis in brown and beige adipocytes enhances the lipolytic processing of triglyceride-rich lipoproteins (TRLs) in plasma to supply these adipocytes with fatty acids for oxidation. This process results in formation of TRL remnants that are removed from the circulation through binding of apolipoprotein E (ApoE) on their surface to the low-densit...
Source: Atherosclerosis - August 9, 2022 Category: Cardiology Authors: Zhixiong Ying Naomi Tramper Enchen Zhou Mari ëtte R Boon Patrick C N Rensen Sander Kooijman Source Type: research

Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity. This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Kaiser Permanente's Good Health & Great Hair Program: Partnering With Barbershops and Beauty Salons to Advance Health Equity in West Baltimore, Maryland
Discussion: The initiative delivered critical health and social support services through a partnership with an established integrated health care system, community barbershops and beauty salons, a mobile health team, and social supports. This novel program utilized a mobile health clinic to provide extensive clinical services complemented by on-site social services. Patterns of service utilization and lessons learned could inform the design of similar programs.
Source: Journal of Public Health Management and Practice - February 1, 2022 Category: Health Management Tags: Practice Full Report Source Type: research