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Three cases of immune ‐mediated necrotizing myopathy with anti‐signal recognition particle antibodies: Extramuscular symptoms preceding progressive muscle weakness
ConclusionsAll three patients visited the internal medicine department before the neurology department. It is important to consider anti ‐SRP myopathy as a differential diagnosis for patients presenting with elevated creatine kinase levels and extramuscular symptoms.
Source: Clinical and Experimental Neuroimmunology - November 21, 2018 Category: Neurology Authors: Yusuke Seino, Takumi Nakamura, Mie Hirohata, Takeshi Kawarabayashi, Mikio Shoji Tags: Case Report Source Type: research

Disinhibiting neurons in the dorsomedial hypothalamus delays the onset of exertional fatigue and exhaustion in rats exercising in a warm environment.
Abstract Stimulants cause hyperthermia, in part, by increasing heat generation through exercise. Stimulants also delay the onset of fatigue and exhaustion allowing animals to exercise longer. If used in a warm environment, this combination (increased exercise and decreased fatigue) can cause heat stroke. The dorsomedial hypothalamus (DMH) is involved in mediating locomotion from stimulants. Furthermore, inhibiting the DMH decreases locomotion and prevents hyperthermia in rats given stimulants in a warm environment. Whether the DMH is involved in mediating exercise-induced fatigue and exhaustion is not known. We hy...
Source: Brain Research - March 22, 2018 Category: Neurology Authors: Zaretsky DV, Kline H, Zaretskaia MV, Brown MB, Durant PJ, Alves NJ, Rusyniak DE Tags: Brain Res Source Type: research

Magnetic resonance imaging findings in heat stroke-related encephalopathy
Ravi K Jakkani, Vijay K Agarwal, Suryanarayana Anasuri, Sriharish Vankayalapati, Rahul Koduri, Sandeep SatyanarayanNeurology India 2017 65(5):1146-1148
Source: Neurology India - September 6, 2017 Category: Neurology Authors: Ravi K Jakkani Vijay K Agarwal Suryanarayana Anasuri Sriharish Vankayalapati Rahul Koduri Sandeep Satyanarayan Source Type: research

Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature
AbstractThis was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2  weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest foll...
Source: The Cerebellum - June 8, 2017 Category: Neurology Source Type: research

Chapter 37 Neurologic complications of acute environmental injuries
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 141 Author(s): I.R.F. da Silva, J.A. Frontera Environmental injuries can result in serious neurologic morbidity. This chapter reviews neurologic complications of thermal burns, smoke inhalation, lightning strikes, electric injury, near drowning, decompression illness, as well as heat stroke and accidental hypothermia. Knowing the pathophysiology and clinical presentation of such injuries is essential to proper management of primary and secondary medical complications. This chapter highlights the most frequently encountered neurologic injuries secondary t...
Source: Handbook of Clinical Neurology - February 9, 2017 Category: Neurology Source Type: research

Mesenchymal stem cell ‐based treatments for stroke, neural trauma, and heat stroke
ConclusionThis review offers a testable platform for targeting microglial‐mediated cytokines in clinical trials based upon the rational design of MSC therapy in the future. MSCs that are derived from the placenta provide a great choice for stem cell therapy. Although targeting the microglial activation is an important approach to reduce the burden of the injury, it is not the only one. This review focuses on this specific aspect. Ischemic stroke, neural trauma, and heatstroke all cause cerebral ischemia‐related deficits. Exogenous MSC therapy is promising as a means of augmenting brain ischemia‐induced deficits. MSC...
Source: Brain and Behavior - August 2, 2016 Category: Neurology Authors: Yogi Chang ‐Yo Hsuan, Cheng‐Hsien Lin, Ching‐Ping Chang, Mao‐Tsun Lin Tags: Review Source Type: research

Heat Stroke from Prolonged Sauna Producing Bilateral Thalamic and Brainstem Hyperintensities on Diffusion-Weighted MRI (P4.400)
Conclusions: We present a case of prolonged hyperthermia producing marked, reversible restricted diffusion in the thalami and brainstem and with a good clinical outcome despite the severity of the initial deficit and imaging findings. This report illustrates the potential reversibility of thermal brain insults and some of the characteristic findings of MR imaging.Disclosure: Dr. Fois has nothing to disclose. Dr. Farrar has nothing to disclose. Dr. Tisch has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Fois, A., Farrar, T., Tisch, S. Tags: General Neurology: Imaging in Clinical Diagnosis Source Type: research

Heat stroke during treatment with olanzapine, trihexyphenidyl, and trazodone in a patient with schizophrenia
Case Report Chin-Pang Lee, Pei-Jung Chen, Chia-Ming Chang, Acta Neuropsychiatrica, Volume 27 Issue 06, pp 380-385Abstract
Source: Acta Neuropsychiatrica - October 27, 2015 Category: Neurology Source Type: research

Diffusion tensor imaging of the cerebellum in patients after heat stroke
Abstract To explore the application value of cerebellar diffusion tensor imaging (DTI) in patients after heat stroke (HS). Eleven patients after HS with a score of 3–9 in Glasgow Coma Scale (GCS) and seven age-matched healthy volunteers were selected to undergo MR examinations during the same hot summer. The MR studies including DTI were performed with a 1.5 T scanner. Fractional anisotropy (FA) values of normal-appearing cerebellar white and gray matter were measured and the differences between the two groups were evaluated with Mann–Whitney U test. The FA value of normal-appearing cerebellar white matte...
Source: Acta Neurologica Belgica - May 20, 2015 Category: Neurology Source Type: research

Acute Vertebrobasilar Territory Infarcts due to Heat Stroke
We report an unusual case of acute vertebrobasilar territory infarcts due to heat stroke. A middle-aged man developed hyperpyrexia (42.2°C) after strenuous fieldwork in a hot summer day. Next morning, he was found in altered sensorium. The brain imaging showed acute posteromedial midbrain and cerebellar infarcts. A diagnosis of acute ischemic stroke due to heat stroke was made, and the patient was put under the intensive care unit.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2015 Category: Neurology Authors: Rajendra Singh Jain, Sunil Kumar, Rakesh Agarwal, Pankaj Kumar Gupta Tags: Case Report Source Type: research

Predictors of Poor Outcome in Neuroleptic Malignant Syndrome: Retrospective Analysis of Nationwide Inpatient Sample (S32.006)
CONCLUSIONS: In patients admitted for neuroleptic malignant syndrome, every decade increment in age, acute kidney injury, seizures and respiratory failure were positive predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Modi has nothing to disclose. Dr. Dharaiya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Modi, S., Dharaiya, D. Tags: Movement Disorders: Tremor, Ataxia, and More Platform Blitz Source Type: research

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