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Specialty: Chemistry
Condition: Heart Disease

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Total 40 results found since Jan 2013.

Statins in stroke.
Conclusion: Treatment with statins prevents ischemic stroke, especially in patients with high cardiovascular risk and established atherosclerotic disease. It seems that both lipid lowering and pleiotropic effects contribute to these effects. PMID: 31218948 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - June 18, 2019 Category: Chemistry Authors: Aznaouridis K, Masoura C, Vlachopoulos C, Tousoulis D Tags: Curr Med Chem Source Type: research

The Role of Nicotinamidephosphoribosyltransferase in Cerebral Ischemia.
Abstract As recombinant tissue plasminogen activator is the only drug approved for the clinical treatment of acute ischemic stroke, there is an urgent unmet need for novel stroke treatments. Endogenous defense mechanisms against stroke may hold the key to new therapies for stroke. A large number of studies suggest that nicotinamidephosphoribosyl-transferase (NAMPT) is an attractive candidate to improve post-stroke recovery. NAMPT is a multifunctional protein and plays important roles in immunity, metabolism, aging, inflammation, and stress responses. NAMPT exists in both the intracellular and extracellular space. ...
Source: Current Topics in Medicinal Chemistry - June 10, 2015 Category: Chemistry Authors: Chen X, Zhao S, Song Y, Shi Y, Leak RK, Cao G Tags: Curr Top Med Chem Source Type: research

Growth Differentiation Factor 15 Predicts All-Cause Morbidity and Mortality in Stable Coronary Heart Disease Proteomics and Protein Markers
CONCLUSIONS: In stable CHD, GDF-15 was independently associated with CV, non-CV, and cancer mortality, as well as with MI and stroke. When also adjusting for other prognostic biomarkers, the associations to all fatal and nonfatal events were maintained except for MI. Information on GDF-15, therefore, might be helpful when assessing the risk of adverse outcomes in patients with stable CHD. ClinicalTrials.gov Identifier: NCT00799903
Source: Clinical Chemistry - December 29, 2016 Category: Chemistry Authors: Hagstrom, E., Held, C., Stewart, R. A. H., Aylward, P. E., Budaj, A., Cannon, C. P., Koenig, W., Krug-Gourley, S., Mohler, E. R., Steg, P. G., Tarka, E., Ostlund, O., White, H. D., Siegbahn, A., Wallentin, L., on behalf of the STABILITY Investigators Tags: Proteomics and Protein Markers Source Type: research

Telomere Length as a marker of biological aging: A critical review of recent literature
CONCLUSION: The present review attempted to examine the purported relation between leukocyte TL and age-related diseases such as CVD and more specific stroke and heart disease in view of the best established, comprehensive, medical and epidemiological criteria that have characterized the focused recent relevant research. Although several recommendations have been made that may contribute significantly to the field, a call for novel technical approaches and studies is mandatory to further elucidate the possible association.PMID:35838223 | DOI:10.2174/0929867329666220713123750
Source: Current Medicinal Chemistry - July 15, 2022 Category: Chemistry Authors: Stylianos Daios Antonia Anogeianaki Georgia Kaiafa Anastasia Kontana Stavroula Veneti Christiana Gogou Eleni Karlafti Dimitrios Pilalas Ilias Kanellos Christos Savopoulos Source Type: research

Health risk and disease burden attributable to long-term global fine-mode particles
This study investigates global spatiotemporal variations in PM2.5 using the newly developed satellite-derived PM2.5 dataset from 1998 to 2018. An integrated exposure-response (IER) model was employed to examine the characteristics of PM2.5-related deaths caused by chronic obstructive pulmonary disease (COPD), ischemic heart disease (IHD), lung cancer (LC), and stroke in adults (age≥25), as well as lower respiratory infection (LRI) in children (age≤5). The results showed that high annual PM2.5 concentrations were observed mainly in East Asia and South Asia. Over the 19-year period, PM2.5 concentrations constantly decrea...
Source: Chemosphere - October 4, 2021 Category: Chemistry Authors: Xingchuan Yang Yuan Wang Chuanfeng Zhao Hao Fan Yikun Yang Yulei Chi Lixing Shen Xing Yan Source Type: research

Insulin secretion and interleukin-1β dependent mechanisms in human diabetes remission after metabolic surgery.
Abstract To compare endocrine, metabolic, and inflammatory changes induced by gastric bypass (GB) and sleeve gastrectomy (SG) in patients with type 2 diabetes mellitus (T2DM), and to investigate the mechanisms of success after metabolic surgery. Sixteen GB and 16 SG patients were followed up before and at 1 year after surgery. The 75-g oral glucose tolerance test (OGTT) was performed before and after surgery. Glucose homeostasis, serum interleukin-1β, plasma gut hormones and adipokines, and the United Kingdom Prospective Diabetes Study (UKPDS) ten-year cardiovascular risks were evaluated. The diabetes remission r...
Source: Current Medicinal Chemistry - May 22, 2013 Category: Chemistry Authors: Chen CY, Lee WJ, Asakawa A, Fujitsuka N, Chong K, Chen SC, Lee SD, Inui A Tags: Curr Med Chem Source Type: research

Homocysteine and migraine. A narrative review.
This article is hence aimed to provide an overview of epidemiological evidence about the association between homocysteine and migraine published in cross-sectional, prospective or interventional studies. Overall, the evidence gathered from cross-sectional studies that measured plasma homocysteine levels suggests that the epidemiological link between the plasma concentration of this biomarker and migraine is very weak, at best. Contradictory evidence emerged from interventional studies, in which treatment of hyperhomocysteinemia with folic acid or vitamin B supplementation was effective to lower plasma homocysteine and decr...
Source: International Journal of Clinical Chemistry - March 5, 2014 Category: Chemistry Authors: Lippi G, Mattiuzzi C, Meschi T, Cervellin G, Borghi L Tags: Clin Chim Acta Source Type: research

Cardiovascular disease detection using bio-sensing techniques.
Abstract Universally, cardiovascular disease (CVD) is recognised as the prime cause of death with estimates exceeding 20 million by 2015 due to heart disease and stroke. Facts regarding the disease, its classification and diagnosis are still lacking. Hence, understanding the issues involved in its initiation, its symptoms and early detection will reduce the high risk of sudden death associated with it. Biosensors developed to be used as rapid screening tools to detect disease biomarkers at the earliest stage and able to classify the condition are revolutionising CVD diagnosis and prognosis. Advances in interdiscip...
Source: Talanta - July 26, 2014 Category: Chemistry Authors: Altintas Z, Fakanya WM, Tothill IE Tags: Talanta Source Type: research

Prognostic Value of Midregional Pro-A-Type Natriuretic Peptide and N-Terminal Pro-B-Type Natriuretic Peptide in Patients with Stable Coronary Heart Disease Followed over 8 Years Proteomics and Protein Markers
CONCLUSIONS: Although we found an independent association of MR-proANP as well as NT-proBNP when used as single markers with recurrent CVD events after adjustment for established risk factors, the results of a simultaneous assessment of both markers indicated that MR-proANP fails to provide additional prognostic information to NT-proBNP in the population studied.
Source: Clinical Chemistry - October 28, 2014 Category: Chemistry Authors: Karakas, M., Jaensch, A., Breitling, L. P., Brenner, H., Koenig, W., Rothenbacher, D. Tags: Proteomics and Protein Markers Source Type: research