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Specialty: Biomedical Science
Condition: Heart Failure

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Total 170 results found since Jan 2013.

Diagnosis of atrial fibrillation in heart failure patients with implantable cardioverter defibrillator or cardiac resynchronisation therapy
CONCLUSIONS: Episodes of paroxysmal atrial fibrillation in patients with systolic heart failure and implanted cardioverter-defibrillator systems are quite common. The majority of the episodes recorded in the study were asymptomatic.PMID:34900037 | PMC:PMC8641502 | DOI:10.5114/aoms/114977
Source: Archives of Medical Science - December 13, 2021 Category: Biomedical Science Authors: Barbara Dominik Przemyslaw Mitkowski Wojciech Zorawski Ilona Kowalik Adam Ciesielski Source Type: research

Smartphone applications for physical activity and sedentary behaviour change in people with cardiovascular disease: A systematic review and meta-analysis
ConclusionsSmartphone applications were effective in increasing physical activity in people with cardiovascular disease. Caution is warranted for the low-quality evidence, small sample and larger coronary heart disease representation. More rigorous research is needed to investigate the effect of smartphone applications across diagnoses and in sedentary behaviour.
Source: PLoS One - October 11, 2021 Category: Biomedical Science Authors: Kacie Patterson Source Type: research

Three year clinical outcomes in a nationwide, observational, siteless clinical trial of atrial fibrillation screening —mHealth Screening to Prevent Strokes (mSToPS)
by Steven R. Steinhubl, Jill Waalen, Anirudh Sanyal, Alison M. Edwards, Lauren M. Ariniello, Gail S. Ebner, Katie Baca-Motes, Robert A. Zambon, Troy Sarich, Eric J. Topol BackgroundAtrial fibrillation (AF) is common, often without symptoms, and is an independent risk factor for mortality, stroke and heart failure. It is unknown if screening asymptomatic individuals for AF can improve clinical outcomes. MethodsmSToPS was a pragmatic, direct-to-participant trial that randomized individuals from a single US-wide health plan to either immediate or delayed screening using a continuous-recording ECG patch to be worn for two week...
Source: PLoS One - October 5, 2021 Category: Biomedical Science Authors: Steven R. Steinhubl Source Type: research

Acute myocardial infarction in the Covid-19 era: Incidence, clinical characteristics and in-hospital outcomes —A multicenter registry
by Alexander Fardman, Doron Zahger, Katia Orvin, Daniel Oren, Natalia Kofman, Jameel Mohsen, Or Tsafrir, Elad Asher, Ronen Rubinshtein, Jafari Jamal, Roi Efraim, Majdi Halabi, Yacov Shacham, Lior Henri Fortis, Tal Cohen, Robert Klempfner, Amit Segev, Roy Beigel, Shlomi Matetzky BackgroundWe aimed to describe the characteristics and in-hospital outcomes of ST-segment elevation myocardial infarction (STEMI) patients during the Covid-19 era. MethodsWe conducted a prospective, multicenter study involving 13 intensive cardiac care units, to evaluate consecutive STEMI patients admitted throughout an 8-week period during the Covi...
Source: PLoS One - June 18, 2021 Category: Biomedical Science Authors: Alexander Fardman Source Type: research

Comparison of long-term outcomes after trans-catheter aortic valve implantation between patients primarily diagnosed by cardiac murmur and those diagnosed by other reasons
by Yousuke Taniguchi, Kenichi Sakakura, Yohei Nomura, Masashi Hatori, Kaho Shibata, Yusuke Tamanaha, Taku Kasahara, Takunori Tsukui, Tatsuro Ibe, Kei Yamamoto, Hiroyuki Jinnouchi, Hiroshi Wada, Atsushi Yamaguchi, Hideo Fujita Careful auscultation is the first step to diagnose aortic stenosis (AS). The aim of this study was to compare clinical outcomes following transcatheter aortic valve implantation (TAVI) between the patients primarily diagnosed by heart murmur and those diagnosed by other reasons. We retrospectively included 258 patients who underwent TAVI in our medical center, and divided those into the murmur group ...
Source: PLoS One - February 19, 2021 Category: Biomedical Science Authors: Yousuke Taniguchi Source Type: research

Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil
Hypertrophic cardiomyopathies (HCMs) are the leading cause of acute cardiac failure in young individuals. Over 300 mutations throughout β-cardiac myosin, including in the motor domain, are associated with HCM. A β-cardiac myosin motor mutation (R712L) leads to a severe form of HCM. Actin-gliding motility of R712L-myosin is inhibited, despite near-normal ATPase kinetics. By optical trapping, the working stroke of R712L-myosin was d ecreased 4-fold, but actin-attachment durations were normal. A prevalent hypothesis that HCM mutants are hypercontractile is thus not universal. R712 is adjacent to the binding site of the hear...
Source: eLife - February 19, 2021 Category: Biomedical Science Tags: Biochemistry and Chemical Biology Structural Biology and Molecular Biophysics Source Type: research

Obesity and mortality after the first ischemic stroke: Is obesity paradox real?
ConclusionOur study results support the obesity paradox in ischemic stroke patients as shown by a significantly decreased hazard ratio for one-year mortality among overweight and obese patients in comparison to non-overweight patients.
Source: PLoS One - February 10, 2021 Category: Biomedical Science Authors: Durgesh Chaudhary Source Type: research

A novel risk model to predict first-ever ischemic stroke in heart failure with reduced ejection fraction.
Abstract Patients with heart failure are at increased risk for ischemic stroke. We aim to develop a more accurate stroke risk prediction tools identify high-risk patients with heart failure with reduced ejection fraction (HFrEF). Patient data were extracted retrospectively from the electronic medical database between January 2009 and February 2019. Univariate and multivariate Cox regression analysis were performed to identify independent predictors, which were utilized to construct a nomogram for predicting ischemic stroke. AUROC analysis was used to compare the prognostic value between the new risk score and CHAD...
Source: Aging - February 1, 2021 Category: Biomedical Science Authors: Zhou X, Yu L, Hu W, Shi R, Ji Y, Zhou C, Xue C, Yu G, Huang W, Shan P Tags: Aging (Albany NY) Source Type: research

Association of digoxin with mortality in patients with advanced chronic kidney disease: A population-based cohort study
In conclusion, our study demonstrated that digoxin use was associated with increased mortality, but not cardiovascular events or renal function decline in advanced CKD patients. This finding warns the safety of presc ribing digoxin in this population. Future prospective studies are needed to overcome the limitations of cohort study design.
Source: PLoS One - January 15, 2021 Category: Biomedical Science Authors: Lii-Jia Yang Source Type: research

Thromboembolism in Patients with Hypertrophic Cardiomyopathy.
Authors: Liu L, Liu Z, Chen X, He S Abstract Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disease, which has a marked heterogeneity in clinical expression, natural history, and prognosis. HCM is associated with a high prevalence of thromboembolic events (stroke and systemic embolic events), even if taking no account of atrial fibrillation (AF), leading to unexpected disability and death in patients of all ages. Several risk factors of thromboembolism such as AF, greater age, left atrial diameter, heart failure and others have been confirmed in patients with HCM. Conventional thromboembolic predictive m...
Source: International Journal of Medical Sciences - January 14, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Disrupted Endothelial Cell Heterogeneity and Network Organization Impair Vascular Function in Prediabetic Obesity
Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke. Impaired endothelial function occurs in the earliest stages of obesity and underlies vascular alterations that give rise to cardiovascular disease. However, the mechanisms that link weight gain to endothelial dysfunction are ill-defined. Increasing evidence suggests that endothelial cells are not a population of uniform cells but are highly heterogeneous and are organized as a communicating multicellular network that controls vascular function.
Source: Metabolism - Clinical and Experimental - August 9, 2020 Category: Biomedical Science Authors: Calum Wilson, Xun Zhang, Matthew D. Lee, Margaret MacDonald, Helen R. Heathcote, Nasser M.N. Alorfi, Charlotte Buckley, Sharron Dolan, John G. McCarron Source Type: research

A review of machine learning techniques in photoplethysmography for the non-invasive cuff-less measurement of blood pressure
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): C. El-Hajj, P.A. KyriacouAbstractHypertension or high blood pressure is a leading cause of death throughout the world and a critical factor for increasing the risk of serious diseases, including cardiovascular diseases such as stroke and heart failure. Blood pressure is a primary vital sign that must be monitored regularly for the early detection, prevention and treatment of cardiovascular diseases. Traditional blood pressure measurement techniques are either invasive or cuff-based, which are impractical, intermittent, and unc...
Source: Biomedical Signal Processing and Control - February 13, 2020 Category: Biomedical Science Source Type: research