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Specialty: Cardiology
Condition: Heart Failure
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Total 4537 results found since Jan 2013.
Association of SGLT2 Inhibitors With Risk of Atrial Fibrillation and Stroke in Patients With and Without Type 2 Diabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials
Abstract:
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have well-documented effects on reducing hospitalization for heart failure and cardiovascular mortality, although the effect on atrial fibrillation (AF) has not been comprehensively investigated. Therefore, we performed a meta-analysis to assess the association between SGLT2 inhibitors and AF risk by systematically searching PubMed, Embase, and ClinicalTrials.gov. Two investigators independently identified randomized controlled trials, which compared SGLT2 inhibitors with control in patients with type 2 diabetes, heart failure, or chronic kidney disease. Prima...
Source: Journal of Cardiovascular Pharmacology - February 1, 2022 Category: Cardiology Tags: Review Article Source Type: research
Embolic infarct topology differs between atrial fibrillation subtypes and embolic stroke of undetermined source
CONCLUSION: Cortical infarctions were twice as common among patients with AF versus ESUS. Subcortical infarct topography was strongly associated with chronic microvascular ischemic changes and therefore may not represent embolic phenomena. Larger-scale investigations are warranted to discern whether large or multifocal subcortical infarcts ought to be excluded from the ESUS designation.PMID:36130470 | DOI:10.1016/j.jstrokecerebrovasdis.2022.106782
Source: Atherosclerosis - September 21, 2022 Category: Cardiology Authors: Jared Wolfe Solomon Oak Justin Tiongson Nicholas Vigilante Emma Frost Mary Penckofer Lauren Thau Zachary Iezzi Pratit Patel James E Siegler Source Type: research
Risk of Stroke in Older Adults With Heart Failure
Heart failure (HF) is a risk factor for incident stroke. However, less is known about the independent nature of this association and to what extent various baseline characteristics may mediate this risk. Of the 5,795 community-dwelling adults aged ≥65 years in the Cardiovascular Health Study, 5,448 were free of baseline stroke, of whom 229 had baseline HF. We used a multivariable-adjusted Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for centrally adjudicated incident stroke associated with HF.
Source: The American Journal of Cardiology - December 10, 2022 Category: Cardiology Authors: Elizabeth Bierbower, Nayrana Griffith, Venkatesh K. Raman, Vijaywant Brar, Jeffrey Roseman, Prakash Deedwania, Gregg C. Fonarow, Richard M. Allman, Charles Faselis, Sijian Zhang, George Howard, Ali Ahmed, Phillip H. Lam Source Type: research
Angiotensin-converting Enzyme Inhibitors (ACE) And Angiotensin Receptor Blockers (ARB) Appear To Attenuate Stroke Risk Over Time In Patients With Left Ventricular Assist Devices
Left ventricular assist devices (LVADs) are used as a bridge to transplant or as a destination therapy for patients with end-stage heart failure. LVADs are associated with increased stroke risk, and many patients on LVAD are treated with ACE/ARBs and vasodilators to keep their mean arterial pressure (MAP) at goal to minimize the risk of stroke. We hypothesized that ACE/ARBs and vasodilators can reduce the 5-year risk of stroke in patients with LVAD.
Source: Journal of Cardiac Failure - April 1, 2023 Category: Cardiology Authors: Jae-Hoon Chung, Jonathan Wright, Mark Boulous, Djhenne Dalmacy, Sakima Smith Tags: 132 Source Type: research
NICE issues final appraisal determination on apixaban for prevention of stroke and systemic embolism in non-valvular atrial fibrillation
Source: NICE
Area: News
In its final appraisal determination (FAD), NICE has supported the use of apixaban as an option for preventing stroke and systemic embolism within its marketing authorisation, that is, in people with nonvalvular atrial fibrillation with one or more risk factors (prior stroke or ischaemic attack, age 75 years or older, hypertension, diabetes mellitus or symptomatic heart failure).
The appeal period for this appraisal will close on 6 February 2013.
Source: NeLM - Cardiovascular Medicine - January 23, 2013 Category: Cardiology Source Type: news
NICE issues final guidance supporting the use of apixaban for prevention of stroke and systemic embolism in non-valvular atrial fibrillation (TA 275)
Source: NICE
Area: Evidence > Guidelines
NICE has issued final guidance (TA 275) supporting the use of apixaban as an option for preventing stroke and systemic embolism within its marketing authorisation, that is, in people with nonvalvular atrial fibrillation with 1 or more risk factors such as:
. prior stroke or transient ischaemic attack
. age 75 years or older
. hypertension
. diabetes mellitus
. symptomatic heart failure.
NICE notes that the decision about whether to start treatment with apixaban should be made after an informed discussion between the clinici...
Source: NeLM - Cardiovascular Medicine - February 27, 2013 Category: Cardiology Source Type: news
Does atrial fibrillation ablation really reduce stroke rates?
Atrial fibrillation (AF) is increasingly becoming common among older people, and its prevalence is around 1% of the adult population in North America (roughly 2.2 million people). Patients with AF have an increased risk of strokes, heart failure, and subsequent mortality. Although antiarrhythmic drugs for restoring sinus rhythm have failed to reduce these risks, a subanalysis showed that achieving sinus rhythm was associated with halving the mortality but this effect was negated if antiarrhythmic therapy was continued. In fact, the ATHENA (A placebo-controlled, double-blind, parallel-arm Trial to assess the efficacy of dro...
Source: Heart Rhythm - July 22, 2013 Category: Cardiology Authors: Yasuo Okumura Tags: Editorial Commentary Source Type: research
Stroke Prevention in Atrial Fibrillation in Heart Failure
Heart failure and atrial fibrillation are major problems of modern cardiology with important clinical, prognostic, and socioeconomic implications. The risks are high morbidity, impaired quality of life, poor outcome, and increased risk of stroke. Oral anticoagulation with vitamin K antagonists or novel licensed medicines should be considered unless contraindicated. Possible benefits of sinus rhythm maintenance are not entirely clear and need to be explored further. Relatively scarce data are available on stroke prevention in atrial fibrillation in heart failure with preserved ejection fraction; this requires further research.
Source: Heart Failure Clinics - September 23, 2013 Category: Cardiology Authors: Eduard Shantsila, Gregory Y.H. Lip Source Type: research
Assessment of stroke risk in Middle Eastern patients with atrial fibrillation: The Gulf SAFE registry
Limited data are available on the epidemiology of AF in non-European, non-Caucasian populations . The aim of the present study was to present the thromboembolic risk profile and for the first time, to validate the performance of the CHADS2 (congestive heart failure, hypertension, age ≥75years, diabetes, stroke/TIA doubled) and CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75years doubled, diabetes, stroke/TIA doubled, vascular disease, age 65–74, sex category [female]) scores in a Middle Eastern population.
Source: International Journal of Cardiology - March 7, 2013 Category: Cardiology Authors: S. Apostolakis, M. Zubaid, W.A. Rashed, A.A. Alsheikh-Ali, W. Almahmeed, A. Shehab, K. Sulaiman, A. AlQudaimi, N. Asaad, H. Amin, D.A. Lane, G.Y.H. Lip, On behalf of the Gulf Survey of Atrial Fibrillation Events (Gulf SAFE) Investigators Tags: Letters to the Editor Source Type: research
Digoxin use is associated with increased risk of stroke in patients with non-valvular atrial fibrillation — a nationwide population-based cohort study
Atrial fibrillation (AF) is associated with increased risk of morbidity and mortality. Digoxin is often used as a rate control agent in AF patients, particularly in those with systolic heart failure. Although digoxin use in AF patients can reduce heart failure symptoms, increase exercise capacity and decrease hospitalizations , unfavorable effects on long-term outcomes have been reported . In the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study, a post-hoc analysis showed a higher rate of mortality in patients treated with digitalis medication . A study of the “Registry of Information and K...
Source: International Journal of Cardiology - September 23, 2013 Category: Cardiology Authors: Shih-Sheng Chang, Kuan-Cheng Chang, Yu-Chen Wang, Chih-Hsin Muo, Pei-Ying Pai, Chi-Bin Chang, Chi-Yuan Li, Fung-Chang Sung Tags: Online Letters to the Editor Source Type: research
Simultaneous onset of myocardial infarction and ischemic stroke in a patient with atrial fibrillation: Multiple territory injury revealed on angiography and magnetic resonance
An 84-year-old man with a history of hypertension and paroxysmal atrial fibrillation (AF) who received no anticoagulant drugs experienced acute chest pain and transient loss of consciousness. He was transferred to our emergency room. His initial electrocardiogram showed sinus rhythm with ST-segment elevation in the I, aVL, and V1–V6 leads. His blood pressure was 158/92mmHg and his pulse was regular at 70beats per minute. A chest radiograph showed increased heart size and pulmonary vascular congestion. His troponin T level was elevated (more than 0.1ng/mL). He was diagnosed with ST-elevation myocardial infarction (MI) and...
Source: International Journal of Cardiology - February 4, 2014 Category: Cardiology Authors: Osamu Hashimoto, Kozo Sato, Yohei Numasawa, Joji Hosokawa, Masahiro Endo Tags: Online Letters to the Editor Source Type: research
Slope in preload recruitable stroke work relationship predicts survival after left ventriculoplasty and mitral repair in patients with idiopathic cardiomyopathy.
CONCLUSIONS: Mw, the slope in the PRSW relationship, may predict survival after LVP and MVP in patients with idiopathic DCM.
PMID: 24954287 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - June 18, 2014 Category: Cardiology Authors: Shingu Y, Kubota S, Wakasa S, Ooka T, Kato H, Tachibana T, Matsui Y Tags: J Cardiol Source Type: research
Subclinical Atrial Fibrillation Preceding Cardioembolic Stroke in a Patient with Systolic Heart Failure
Atrial fibrillation and congestive heart failure are risk factors for cerebral infarction. The most commonly used estimates of stroke risk in patients with atrial fibrillation are cardiac failure, hypertension, age, diabetes mellitus, and stroke (CHADS2 score) [1–4]. Although atrial fibrillation may be recognized by the presence of symptoms, such as palpitations, some patients are occasionally asymptomatic [5–7]. The absence of symptoms results in a delayed diagnosis, and may lead to fatal thromboembolic events.
Source: International Journal of Cardiology - August 13, 2014 Category: Cardiology Authors: Kihei Yoneyama, Tomoo Harada, Hidemichi Ito, Makoto Takano, Maya Tsukahara, Yukio Sato, Masashi Uchida, Satoru Nishio, Yoshihiro J. Akashi Source Type: research
Subclinical atrial fibrillation preceding cardioembolic stroke in a patient with systolic heart failure
Atrial fibrillation and congestive heart failure are risk factors for cerebral infarction. The most commonly used estimates of stroke risk in patients with atrial fibrillation are cardiac failure, hypertension, age, diabetes mellitus, and stroke (CHADS2 score) [1–4]. Although atrial fibrillation may be recognized by the presence of symptoms, such as palpitations, some patients are occasionally asymptomatic [5–7]. The absence of symptoms results in a delayed diagnosis and may lead to fatal thromboembolic events.
Source: International Journal of Cardiology - August 13, 2014 Category: Cardiology Authors: Kihei Yoneyama, Tomoo Harada, Hidemichi Ito, Makoto Takano, Maya Tsukahara, Yukio Sato, Masashi Uchida, Satoru Nishio, Yoshihiro J. Akashi Tags: Letter to the Editor Source Type: research
