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Specialty: Hematology
Condition: Heart Attack

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Total 519 results found since Jan 2013.

Associations of Pentraxin 3 with Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
CONCLUSIONS: In these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis. This article is protected by copyright. All rights reserved. PMID: 24628740 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 13, 2014 Category: Hematology Authors: Jenny NS, Blumenthal RS, Kronmal RA, Rotter JI, Siscovick DS, Psaty BM Tags: J Thromb Haemost Source Type: research

Fibrin clot properties and their modulation in thrombotic disorders.
Abstract Accumulating evidence indicates that accelerated formation of fibrin clots composed of compact, highly-branched networks with thin fibres which are relatively resistant to plasmin-mediated lysis can be commonly observed in patients with venous or arterial thrombosis. This review discusses characteristics of fibrin clot structure and function in patients with various thromboembolic manifestations, in particular myocardial infarction, ischaemic stroke and venous thromboembolism, based on the publications till December 2013. Moreover, factors will be presented that in vivo unfavorably determine altered fibri...
Source: Thrombosis and Haemostasis - March 27, 2014 Category: Hematology Authors: Undas A Tags: Thromb Haemost Source Type: research

Tolerance of intraoperative hemoglobin decrease during cardiac surgery.
CONCLUSIONS: Our findings show that a decrease of at least 50% from baseline Hb during cardiac surgery is associated with adverse outcomes, even if the absolute Hb level remains higher than the commonly used transfusion threshold of 7.0 g/dL. PMID: 24724943 [PubMed - as supplied by publisher]
Source: Transfusion - April 14, 2014 Category: Hematology Authors: Hogervorst E, Rosseel P, van der Bom J, Bentala M, Brand A, van der Meer N, van de Watering L Tags: Transfusion Source Type: research

Risk Assessment to Predict Arterial and Venous Events in Patients Undergoing Percutaneous Coronary Intervention
Atherosclerosis and venous thromboembolism (VTE) share common risk factors. We set to assess the strength of the association between atherosclerosis risk factors and disease manifestation, and VTE, in patients with coronary artery disease undergoing percutaneous coronary intervention. We pooled data from 6 global randomized controlled trials assessing coronary stenting (ENDEAVOR and SIRIUS programs), developed separate risk scores to predict major adverse cardiac and cerebrovascular events (MACCEs: cardiac death, myocardial infarction, and stroke) and VTE, and compared their performance. The 5-year rates of MACCE and VTE w...
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2014 Category: Hematology Authors: Vardi, M., Piazza, G., Pencina, M. J., Burke, D. A., Lei, L., Goldhaber, S. Z., Cutlip, D. E. Tags: Original Articles Source Type: research

Associations of pentraxin 3 with cardiovascular disease: the Multi‐Ethnic Study of Atherosclerosis
ConclusionsIn these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independently of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP, and may provide additional insights into the development and progression of atherosclerosis.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: N. S. Jenny, R. S. Blumenthal, R. A. Kronmal, J. I. Rotter, D. S. Siscovick, B. M. Psaty Tags: Original Article Source Type: research

The Effects of Lysine Analogs During Pelvic Surgery: A Systematic Review and Meta-Analysis
The objective of this study was to assess the safety and efficacy of lysine analogs during pelvic surgery. A systematic literature search was performed using Medline, Cochrane Register of Clinical Trials, Embase, and the reference lists of relevant articles. Randomized controlled trials or observational cohort studies comparing a lysine analog to placebo or standard care were included. Outcomes collected were blood transfusion, blood loss, thromboembolic adverse events (myocardial infarction, stroke, deep vein thrombosis, and pulmonary embolism), nonthromboembolic adverse events, and death. There were no language limitatio...
Source: Transfusion Medicine Reviews - May 20, 2014 Category: Hematology Authors: Rodney H. Breau, Madzouka B. Kokolo, Nahid Punjani, Ilias Cagiannos, Andrew Beck, Naomi Niznick, Chieny Buenaventura, Juthaporn Cowan, Gregory Knoll, Franco Momoli, Chris Morash, Marcel Ruzicka, Svetlana Schachkina, Alan Tinmouth, Hai Yan Xie, Dean A. Fer Tags: Original Articles Source Type: research

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function
Pathologic blood clotting is a leading cause of morbidity and mortality in the developed world, underlying deep vein thrombosis, myocardial infarction, and stroke. Genetic predisposition to thrombosis is still poorly understood, and we hypothesize that there are many additional risk alleles and modifying factors remaining to be discovered. Mammalian models have contributed to our understanding of thrombosis, but are low throughput and costly. We have turned to the zebrafish, a tool for high-throughput genetic analysis. Using zinc finger nucleases, we show that disruption of the zebrafish antithrombin III (at3) locus result...
Source: Blood - July 3, 2014 Category: Hematology Authors: Liu, Y., Kretz, C. A., Maeder, M. L., Richter, C. E., Tsao, P., Vo, A. H., Huarng, M. C., Rode, T., Hu, Z., Mehra, R., Olson, S. T., Joung, J. K., Shavit, J. A. Tags: Thrombosis and Hemostasis Source Type: research

Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome.
Abstract Acute coronary syndrome (ACS) is a medical emergency. Patients who survive the initial event remain at risk of recurrent cardiovascular events. In most cases, ACS is triggered by thrombosis after rupture of an atherosclerotic plaque. Key to thrombus formation at this site is the generation of thrombin, which not only converts fibrinogen to fibrin but also serves as a potent platelet agonist and induces platelet aggregation at the site of vascular injury. Although dual antiplatelet therapy is more effective for the prevention of recurrent events than aspirin alone after ACS, there remains an approximately ...
Source: Thrombosis and Haemostasis - July 17, 2014 Category: Hematology Authors: Weitz JI Tags: Thromb Haemost Source Type: research

Erythropoiesis-stimulating agents and thrombotic events in dialysis patients
Erythropoiesis-stimulating agents (ESA) have been associated with a higher cardiovascular event and mortality rate in dialysis patients. The ESA-associated risk of arterial thrombotic events is mainly based on composite endpoints of anemia-correction trials targeting high hemoglobin levels. The ESA-associated risk of venous thromboembolism (VTE) has not been studied in dialysis patients yet. We therefore aimed to determine the association between ESA use and dose with ischemic stroke, myocardial infarction (MI) and VTE.
Source: Thrombosis Research - August 1, 2014 Category: Hematology Authors: Marit M. Suttorp, Tiny Hoekstra, Gürbey Ocak, Anouk T.N. van Diepen, Ilka Ott, Moshe Mittelman, Ton J. Rabelink, Raymond T. Krediet, Friedo W. Dekker Source Type: research

Aspirin-Responsive, Migraine-Like Transient Cerebral and Ocular Ischemic Attacks and Erythromelalgia in JAK2-Positive Essential Thrombocythemia and Polycythemia Vera.
Abstract Migraine-like cerebral transient ischemic attacks (MIAs) and ocular ischemic manifestations were the main presenting features in 10 JAK2(V617F)-positive patients studied, with essential thrombocythemia (ET) in 6 and polycythemia vera (PV) in 4. Symptoms varied and included cerebral ischemic attacks, mental concentration disturbances followed by throbbing headaches, nausea, vomiting, syncope or even seizures. MIAs were frequently preceded or followed by ocular ischemic events of blurred vision, scotomas, transient flashing of the eyes, and sudden transient partial blindness preceded or followed erythromela...
Source: Acta Haematologica - August 7, 2014 Category: Hematology Authors: Michiels JJ, Berneman Z, Gadisseur A, Lam KH, De Raeve H, Schroyens W Tags: Acta Haematol Source Type: research

The impact of renal function on platelet reactivity and clinical outcome in patients undergoing percutaneous coronary intervention with stenting.
In conclusion, the magnitude of platelet reactivity as well as the incidence of HPR was higher in patients with CKD. However, since the incidence of HPR was similar after adjustment, a higher rate of co-morbidities in patients with CKD might be the major cause for this observation rather than CKD itself. CKD-patients with HCPR were at the highest risk of long-term cardiovascular events. PMID: 25231776 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 18, 2014 Category: Hematology Authors: Breet NJ, de Jong C, Bos WJ, van Werkum JW, Bouman HJ, Kelder JC, Bergmeijer TO, Zijlstra F, Hackeng CM, Ten Berg JM Tags: Thromb Haemost Source Type: research

Serial clopidogrel dose adjustment after platelet function testing improves outcome of acute coronary syndrome patients undergoing percutaneous coronary intervention with high on-treatment platelet reactivity
Abstract High on-treatment platelet reactivity (HTPR) on clopidogrel correlates with adverse outcomes in patients treated with percutaneous coronary intervention (PCI). Whether HTPR is a modifiable risk factor for future events is not clear. We evaluated the effect of serial clopidogrel dose adjustment based on platelet function testing (PFT) during 12 months of dual antiplatelet therapy (DAPT) using Multiplate® analyzer in patients with HTPR after PCI in acute coronary syndrome on clinical outcome. Eighty-seven patients were randomized to interventional (n = 43) and control group (n = 44). Blood samples fo...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Platelet 12-LOX is essential for Fc{gamma}RIIa-mediated platelet activation
In this study, we show for the first time that platelet 12(S)-lipoxygenase (12-LOX), a highly expressed oxylipin-producing enzyme in the human platelet, is an essential component of FcRIIa-mediated thrombosis. Pharmacologic inhibition of 12-LOX in human platelets resulted in significant attenuation of FcRIIa-mediated aggregation. Platelet 12-LOX was shown to be essential for FcRIIa-induced phospholipase C2 activity leading to activation of calcium mobilization, Rap1 and protein kinase C activation, and subsequent activation of the integrin αIIbβ3. Additionally, platelets from transgenic mice expressing human FcR...
Source: Blood - October 2, 2014 Category: Hematology Authors: Yeung, J., Tourdot, B. E., Fernandez-Perez, P., Vesci, J., Ren, J., Smyrniotis, C. J., Luci, D. K., Jadhav, A., Simeonov, A., Maloney, D. J., Holman, T. R., McKenzie, S. E., Holinstat, M. Tags: Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Perioperative management of oral antiplatelet therapy and clinical outcomes in coronary stent patients undergoing surgery. Results of a multicentre registry.
In conclusion antiplatelet discontinuation increases the 30-day risk of MACE, in patients with coronary stents undergoing cardiac and non-cardiac surgery, while not offering significant protection from BARC≥ 2 bleeding. PMID: 25274620 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - October 2, 2014 Category: Hematology Authors: Rossini R, Musumeci G, Capodanno D, Lettieri C, Limbruno U, Tarantini G, Russo N, Calabria P, Romano M, Inashvili A, Sirbu V, Guagliumi G, Valsecchi O, Senni M, Gavazzi A, Angiolillo DJ Tags: Thromb Haemost Source Type: research