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Ultrasound ‑targeted microbubble destruction‑mediated Galectin‑7‑siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats.
In conclusion, the present study demonstrated that UTMD‑mediated Galectin‑7‑siRNA treatment could enhance the homing ability of BMSCs, thus alleviating AMI in rats. PMID: 33416139 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - December 23, 2020 Category: Molecular Biology Authors: Wei X, Zheng Y, Zhang W, Tan J, Zheng H Tags: Int J Mol Med Source Type: research

Dysregulation of CD69 by overexpression of microRNA ‑367‑3p associated with post‑myocardial infarction cardiac fibrosis.
In conclusion, these results provide evidence that a decrease in miR‑367‑3p levels may be associated with cardiac fibrosis. PMID: 30015935 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 18, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Microglial Mincle receptor in the PVN contributes to sympathetic hyperactivity in acute myocardial infarction rat.
Abstract Malignant ventricular arrhythmias (VAs) following myocardial infarction (MI) is a lethal complication resulting from sympathetic nerve hyperactivity. Numerous evidence have shown that inflammation within the paraventricular nucleus (PVN) participates in sympathetic hyperactivity. Our aim was to explore the role of Macrophage-inducible C-type lectin (Mincle) within the PVN in augmenting sympathetic activity following MI,and whether NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome/IL-1β axis is involved in this activity. MI was induced by coronary artery ligation. Mincle expression l...
Source: J Cell Mol Med - October 24, 2018 Category: Molecular Biology Authors: Wang Y, Yin J, Wang C, Hu H, Li X, Xue M, Liu J, Cheng W, Wang Y, Li Y, Shi Y, Tan J, Li X, Liu F, Liu Q, Yan S Tags: J Cell Mol Med Source Type: research

Mineralocorticoid receptor deficiency improves the therapeutic effects of mesenchymal stem cells for myocardial infarction via enhanced cell survival.
Abstract The poor survival of stem cells seriously limits their therapeutic efficacy for myocardial infarction (MI). Mineralocorticoid receptor (MR) activation plays an important role in the pathogenesis of multiple cardiovascular diseases. Here, we examined whether MR silencing in bone marrow derived mesenchymal stem cells (MSCs) could improve MSCs' survival and enhance their cardioprotective effects in MI. MSCs from male Sprague-Dawley rats were transfected with adenoviral small interfering RNA to silence MR (siRNA-MR). MR silencing decreased hypoxia-induced MSCs' apoptosis, as demonstrated by Annexin V/7-AAD st...
Source: J Cell Mol Med - December 13, 2018 Category: Molecular Biology Authors: Xie X, Shen Y, Chen J, Huang Z, Ge J Tags: J Cell Mol Med Source Type: research

Inhibition of lncRNA < em > SNHG8 < /em > plays a protective role in  hypoxia-ischemia-reoxygenation-induced myocardial injury by regulating miR-335 and RASA1 expression
Mol Med Rep. 2021 Aug;24(2):597. doi: 10.3892/mmr.2021.12236. Epub 2021 Jun 24.ABSTRACTLong non‑coding (lnc)RNAs serve a role in a number of diseases, including different types of cancer and acute myocardial infarction. The aim of the present study was to investigate the protective role of lncRNA small nucleolar RNA host gene 8 (SNHG8) in hypoxia‑ischemia‑reoxygenation (HI/R)‑induced myocardial injury and its potential mechanism of action. Cell viability, proliferation, creatine kinase myocardial band, cell apoptosis and protein expression levels were determined by Cell Counting Kit‑8 assay, EdU assay, ELISA, flo...
Source: Molecular Medicine - June 24, 2021 Category: Molecular Biology Authors: Yanfeng Liu Ping Zhou Fengxiao Wang Xuehong Zhang Dongmei Yang Lang Hong Dongyun Ruan Source Type: research

Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress.
Abstract Exendin-4 (ex-4) is a long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist which exerts beneficial effects on glycemic control and promotes cell viability. In the present study, we investigated the anti-apoptotic effects of ex-4, as well as the potential mechanisms responsible for these effects in rat bone marrow-derived mesenchymal stem cells (BM-MSCs) under conditions of oxygen, glucose and serum deprivation (OGD). The apoptosis of the MSCs was induced by subjecting the cells to OGD conditions for 4 h and was detected by Annexin V/PI and Hoechst 33258 staining. The MSCs were pre-conditio...
Source: International Journal of Molecular Medicine - February 29, 2016 Category: Molecular Biology Authors: He J, Wang C, Sun Y, Lu B, Cui J, Dong N, Zhang M, Liu Y, Yu B Tags: Int J Mol Med Source Type: research

Macrophage migration inhibitory factor promotes cardiac stem cell proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK pathways.
In conclusion, our results suggest that MIF promotes mCSC survival, proliferation and endothelial differentiation through the activation of the PI3K/Akt/mTOR and AMPK signaling pathways. Thus, MIF may prove to be a potential therapeutic factor in the treatment of heart failure and myocardial infarction by activating CSCs. PMID: 27035848 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - March 28, 2016 Category: Molecular Biology Authors: Cui J, Zhang F, Wang Y, Liu J, Ming X, Hou J, Lv B, Fang S, Yu B Tags: Int J Mol Med Source Type: research

Suppressive effect of epigallocatechin‐3‐O‐gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo
In conclusion, epigallocatechin‐3‐O‐gallate (EGCG) attenuated the endoglin expression and myocardial fibrosis by anti‐inflammatory effect in vitro and in vivo, the novel suppressive effect was mediated through JNK/AP‐1 pathway.
Source: Journal of Cellular and Molecular Medicine - June 15, 2016 Category: Molecular Biology Authors: Chiu‐Mei Lin, Hang Chang, Bao‐Wei Wang, Kou‐Gi Shyu Tags: Original Article Source Type: research

Suppressive effect of epigallocatechin-3-O-gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo.
In conclusion, epigallocatechin-3-O-gallate (EGCG) attenuated the endoglin expression and myocardial fibrosis by anti-inflammatory effect in vitro and in vivo, the novel suppressive effect was mediated through JNK/AP-1 pathway. PMID: 27306149 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - June 15, 2016 Category: Molecular Biology Authors: Lin CM, Chang H, Wang BW, Shyu KG Tags: J Cell Mol Med Source Type: research

Suppressive effect of epigallocatechin ‐3‐O‐gallate on endoglin molecular regulation in myocardial fibrosis in vitro and in vivo
In conclusion, epigallocatechin‐3‐O‐gallate (EGCG) attenuated the endoglin expression and myocardial fibrosis by anti‐inflammatory effect in vitro and in vivo, the novel suppressive effect was mediated through JNK/AP‐1 pathway.
Source: Journal of Cellular and Molecular Medicine - June 15, 2016 Category: Molecular Biology Authors: Chiu ‐Mei Lin, Hang Chang, Bao‐Wei Wang, Kou‐Gi Shyu Tags: Original Article Source Type: research

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