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Synergistic relationship between TSLP and IL ‐33/ST2 signaling pathways in allergic rhinitis and the effects of hypoxia
ConclusionOur data indicate that TSLP and IL ‐33/ST2 signaling pathways interact with each other in the pathogenesis and pathologic development of AR. TSLP inhibition is a key factor in AR treatment. Inhibiting hypoxia‐induced pathologic processes could represent a therapeutic effect by inhibiting IL‐33/ST2 expression via downregulating TSLP.
Source: International Forum of Allergy and Rhinology - January 9, 2020 Category: Allergy & Immunology Authors: Ruofei Huang, Wei Mao, Guoliang Wang, Jian Ding, Ying Sun, Gang Gao, Ping Dong, Zhenfeng Sun Tags: ORIGINAL ARTICLE Source Type: research

Indoor mould exposure, asthma and rhinitis: findings from systematic reviews and recent longitudinal studies
Starting from the Institute of Medicine (IOM) and World Health Organization (WHO) reports, this review provides an overview of the literature published from 2006 to 2017 on the associations between indoor mould exposure and asthma and rhinitis separately in children and adults with a focus on longitudinal epidemiological studies. A systematic search of peer-reviewed literature was performed, including systematic reviews and meta-analyses, longitudinal, incident case–control and panel studies. 61 publications were identified reporting visible mould or mould odour or quantitative assessment of culturable fungi or mould...
Source: European Respiratory Review - May 15, 2018 Category: Respiratory Medicine Authors: Caillaud, D., Leynaert, B., Keirsbulck, M., Nadif, R., on behalf of the mould ANSES working group Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy Reviews Source Type: research

Breast-feeding and risk of asthma, hay fever, and eczema
The World Health Organization recommends breast-feeding for at least 6  months after delivery because of general health benefits for the child.1 However, studies on breast-feeding have yielded inconsistent results regarding its association with the risks for developing asthma, hay fever, and eczema.2-4 A large homogeneous population-based cohort, such as the one used in this study (UK Biobank; N = 502,682), provides statistical power to fill in unaddressed gaps in the knowledge on the effects of breast-feeding on the risks of developing asthma, hay fever, and eczema.
Source: Journal of Allergy and Clinical Immunology - November 10, 2017 Category: Allergy & Immunology Authors: Weronica E. Ek, Torgny Karlsson, Carlos Azuaje Hern ándes, Mathias Rask-Andersen, Åsa Johansson Tags: Letter to the Editor Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Multiple Threats to Child Health from Fossil Fuel Combustion: Impacts of Air Pollution and Climate Change
Conclusion: Going beyond the powerful scientific and economic arguments for urgent action to reduce the burning of fossil fuels is the strong moral imperative to protect our most vulnerable populations. Citation: Perera FP. 2017. Multiple threats to child health from fossil fuel combustion: impacts of air pollution and climate change. Environ Health Perspect 125:141–148; http://dx.doi.org/10.1289/EHP299 Address correspondence to F.P. Perera, Department of Environmental Health Sciences, Columbia Center for Children’s Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th St. 12th flo...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Commentaries Children's Health February 2017 Source Type: research

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
AbstractThe Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA —disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vie...
Source: Clinical and Translational Allergy - December 29, 2016 Category: Allergy & Immunology Source Type: research

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
Abstract Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR ( Contre les MAladies Chroniques pour un VIeillissement Actif ) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AI...
Source: Clinical and Translational Allergy - July 28, 2016 Category: Allergy & Immunology Source Type: research

Air Quality and Climate Change: A Delicate Balance
Background image: © Elenamiv/Shutterstock John H. Tibbetts, based in Charleston, SC, is former editor of Coastal Heritage, the magazine of the South Carolina Sea Grant Consortium. About This Article open Citation: Tibbetts JH. 2015. Air quality and climate change: a delicate balance. Environ Health Perspect 123:A148–A153; http://dx.doi.org/10.1289/ehp.123-A148 News Topics: Air Pollution, Allergies, Asthma, Cardiovascular Health, Climate Change, Combustion Emissions, Dust, Natural Disasters, Ozone, Particulate Matter (PM), Pollen, Mold and Mycotoxins, Respiratory Health, Temperature, Weather Processes Published: 1 Jun...
Source: EHP Research - June 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Air Pollution Allergies Asthma Cardiovascular Health Climate Change Combustion Emissions Dust June 2015 Mold and Mycotoxins Natural Disasters Ozone Particulate Matter (PM) Pollen Respiratory Health Tem Source Type: research

Active or Passive Exposure to Tobacco Smoking and Allergic Rhinitis, Allergic Dermatitis, and Food Allergy in Adults and Children: A Systematic Review and Meta-Analysis
Conclusions We observed very modest associations between smoking and some allergic diseases among adults. Among children and adolescents, both active and passive exposure to SHS were associated with a modest increased risk for allergic diseases, and passive smoking was associated with an increased risk for food allergy. Additional studies with detailed measurement of exposure and better case definition are needed to further explore the role of smoking in allergic diseases.Please see later in the article for the Editors' Summary
Source: PLoS Medicine - March 11, 2014 Category: Internal Medicine Authors: Jurgita Saulyte et al. Source Type: research