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Specialty: Geriatrics
Condition: Dementia

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Total 327 results found since Jan 2013.

426 prevalence of, and risk factors for, dementia in adult outpatient referrals to a regional referral hospital in arusha, tanzania
ConclusionsThe prevalence of dementia in this population is lower than previously reported community-based rates in Tanzania, and similar to those in high-income countries. This is the first time the association between uncorrected visual impairment and dementia has been reported in SSA. Other associations identified are in keeping with previous literature. Further research on the management of dementia and its risk factors, and the support and education of carers and patients in east African populations is required.
Source: Age and Ageing - June 12, 2021 Category: Geriatrics Source Type: research

The Neuroinflammasome in Alzheimer ’s Disease and Cerebral Stroke
Conclusions: AAD can occasionally exacerbate AD and stroke. DDS can alleviate mild cognitive impairment (MCI), early AD and stroke. We clinically confirmed the role of DDS as a neuroinflammasome competitor after stroke. DDS preserved neuronal survival within 24 –55 h in the Seoul Study cohort.Dement Geriatr Cogn Disord Extra 2021;11:159 –167
Source: Dementia and Geriatric Cognitive Disorders Extra - June 10, 2021 Category: Geriatrics Source Type: research

Epilepsy in the aged : Challenges in diagnostics and treatment
Z Gerontol Geriatr. 2021 Apr 23. doi: 10.1007/s00391-021-01882-y. Online ahead of print.ABSTRACTEpilepsy is the third most frequent neurological disorder in aged patients after stroke and dementia. The incidence of epilepsy increases with age with the highest rates in patients ≥ 65 years old. Due to demographic changes the number of aged patients with epilepsy is expected to increase further in the coming years. The leading cause of new onset epilepsy in aged patients is cerebrovascular disease followed by dementia. The recognition of seizures in aged patients is often delayed. Status epilepticus occurs more frequently i...
Source: Zeitschrift fur Gerontologie und Geriatrie - April 23, 2021 Category: Geriatrics Authors: Alexandra Rohracher Eugen Trinka Source Type: research

Efficacy and Safety of the Association of Nimodipine and Choline Alphoscerate in the Treatment of Cognitive Impairment in Patients with Cerebral Small Vessel Disease. The CONIVaD Trial
ConclusionPatients ’ adherence to treatment was low. With this limitation, the combined choline alphoscerate–nimodipine treatment showed no significant effect in our cohort of VCI patients with SVD. The safety profile was good overall.Trial RegistrationClinical Trial NCT03228498. Registered 25 July 2017.
Source: Drugs and Aging - April 15, 2021 Category: Geriatrics Source Type: research

The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation
ConclusionsMethylnaltrexone use did not adversely affect pain control, opioid withdrawal effects, or AEs while providing effective RFL, regardless of age. These results suggest that age does not appear to influence the safety and efficacy of methylnaltrexone for OIC. Further research is needed to assess the impact of other factors that alter BBB permeability, such as dementia, stroke, or drug interactions, on the safety and efficacy of methylnaltrexone.Clinical Trial Registration NumbersStudy 302, NCT00402038; study 3200K1-4000, NCT00672477; study 3200K1-3356, NCT00529087; study 3201, NCT01186770.
Source: Drugs and Aging - March 31, 2021 Category: Geriatrics Source Type: research

Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: A Mendelian randomization study
Neurobiol Aging. 2021 Feb 21;102:161-169. doi: 10.1016/j.neurobiolaging.2021.02.010. Online ahead of print.ABSTRACTTo establish causal evidence for the association of adiposity-related metabolic abnormalities with brain volumes, and the risks of dementia and stroke, we applied 1- and 2-sample Mendelian randomization (MR) analyses using up to 336,309 UK Biobank participants. We used 3 classes of genetic instruments, which all increase body mass index but are associated with different metabolic profiles (unfavorable, neutral and favorable). We validated the instruments using anthropometric and cardio-metabolic traits. Both m...
Source: Neurobiology of Aging - March 26, 2021 Category: Geriatrics Authors: Anwar Mulugeta Amanda Lumsden Elina Hypp önen Source Type: research

Productive Aging During COVID-19 - Lessons from WH SeniorLink
According to the National Academies of Science, Medicine, and Engineering, even before the pandemic, 24% of Americans 65+ were considered socially isolated, and 43% of adults 60+ were lonely. Both experiences are associated with serious physical and mental health problems, including increased risks of dementia, stroke, depression, and suicidal ideation. As older adults engage in stricter social distancing to protect themselves from COVID-19, their risk of social isolation and loneliness is heightened.
Source: The American Journal of Geriatric Psychiatry - March 17, 2021 Category: Geriatrics Authors: Daniella Spencer-Laitt, Mark Nathanson, Marie Spence Tags: Poster Number: EI-61 Source Type: research

Association between vision impairment and cognitive decline in older adults with stroke: Health and Retirement Study.
Abstract Stroke survivors may experience multiple residual symptoms post-stroke, including vision impairment (VI) and cognitive decline. Prior studies have shown that VI is associated with cognitive decline, but have not evaluated the contribution of VI to post-stroke cognitive changes. We used data from four waves (2010-2016) of the Health and Retirement Study to investigate the cognitive trajectories of stroke survivors with and without VI. Vision (excellent-very good[ref], good, fair-poor) and stroke diagnosis were self-reported. Cognition was defined using the Telephone Interview for Cognitive Status. Regressi...
Source: Aging Clinical and Experimental Research - January 11, 2021 Category: Geriatrics Authors: Hreha KP, Downer B, Ehrlich JR, Howrey B, Taglialatela G Tags: Aging Clin Exp Res Source Type: research

'We're not doing it to be nasty': Caregivers' ethical dilemmas in negotiating driving safety with older adults.
Abstract The purpose of this research was to investigate how informal caregivers of older adults cope with and negotiate driving safety when their loved one is no longer safe to drive. Fifteen informal caregivers of an older adult living at home took part in the present study. Participants cared for individuals with a range of health conditions that significantly impaired driving safety, including dementia, Parkinson's disease, macular degeneration, and stroke. A thematic analysis of participants' accounts identified the complex interpersonal, social, and organisational context they encountered when their loved on...
Source: Canadian Journal on Aging - January 5, 2021 Category: Geriatrics Authors: Lafrance MN, Dreise E, Gouliquer L, Poulin C Tags: Can J Aging Source Type: research

Prevalence of atrial fibrillation and outcomes in older long-term care residents: a systematic review
Conclusionestimates of AF prevalence and factors associated with AC prescription varied extensively. Limited data on outcomes prevent the drawing of definitive conclusions. We recommend panel data collection and systems for linkage to create longitudinal cohorts to provide more robust evidence.
Source: Age and Ageing - December 31, 2020 Category: Geriatrics Source Type: research

Effect of the COVID-19 lockdown on disease recognition and utilisation of healthcare services in the older population in Germany: a cross-sectional study
ConclusionThe data suggest that organisational changes were adopted quickly by practice management but also raise concerns about the maintenance of routine care. Prospective studies should evaluate the long-term effects of lockdowns on patient-related outcomes.
Source: Age and Ageing - November 17, 2020 Category: Geriatrics Source Type: research

Neurodegenerative disease is associated with increased incidence of epilepsy: a population based study of older adults
ConclusionIncident epilepsy is more frequently diagnosed among neurodegenerative disease patients, particularly when preceded by a diagnosis of depression, TBI or stroke. Further studies into the differences in epilepsy risk between these two populations may help elucidate different mechanisms of epileptogenesis.
Source: Age and Ageing - October 7, 2020 Category: Geriatrics Source Type: research