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Specialty: Geriatrics
Condition: Dementia
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Total 327 results found since Jan 2013.
Evaluating feasibility, value and characteristics of an intergenerational friendly telephone visit program during the Covid-19 pandemic
Social isolation and loneliness are increasingly recognized as serious health risks for older Americans (1). Social isolation and loneliness are related forms of social disconnection that are associated with the incidence and worsening of anxiety and depressive disorders, coronary artery disease and stroke, dementia, and premature death (2-6). Thus, social distancing policies and isolation during the Covid-19 pandemic have uniquely impacted older adults.
Source: The American Journal of Geriatric Psychiatry - December 23, 2022 Category: Geriatrics Authors: Anagha B. Kumar, Benjamin S. Zide, Twisha Bhardwaj, Jessica M. Lipschitz, Abby N. Altman, Nancy J. Donovan Tags: Regular Research Article Source Type: research
As some hail new antibody treatment for Alzheimer ’s, safety and benefit questions persist
In a packed San Francisco conference room with a celebratory atmosphere, upbeat company representatives and scientists yesterday presented detailed clinical trial data on the first Alzheimer’s treatment shown to clearly, albeit modestly, slow the disease’s normal cognitive decline. The antibody therapy has buoyed a field marked by decades of failures. Now, it appears to be on the cusp of being greenlit by the U.S. Food and Drug Administration (FDA). Yet other researchers warn of potential risks, including brain swelling and brain hemorrhages that were linked to the recently disclosed deaths of two trial participants wh...
Source: Science of Aging Knowledge Environment - December 1, 2022 Category: Geriatrics Source Type: research
Invited commentary: The vascular apathy hypothesis and its meaning for clinicians
For geriatric psychiatrists, apathy is one of the most challenging syndromes to diagnose and treat. Although it is a common syndrome characterized by a lack of motivation1, it is striking to observe how frequently apathy is missed or misdiagnosed in clinical settings. It often underlies treatment resistance, which can leave patients, caregivers, and clinicians feeling frustrated with a perceived lack of progress. Apathy is the most common neuropsychiatric symptom of dementia, but it is also seen in numerous neurological diseases including stroke and Parkinson's disease, and it may co-occur with depression.
Source: The American Journal of Geriatric Psychiatry - October 22, 2022 Category: Geriatrics Authors: Stephanie Collier Tags: Editorial Source Type: research
The Vascular Apathy Hypothesis and Its Meaning for Clinicians
For geriatric psychiatrists, apathy is one of the most challenging syndromes to diagnose and treat. Although it is a common syndrome characterized by a lack of motivation,1 it is striking to observe how frequently apathy is missed or misdiagnosed in clinical settings. It often underlies treatment resistance, which can leave patients, caregivers, and clinicians feeling frustrated with a perceived lack of progress. Apathy is the most common neuropsychiatric symptom of dementia, but it is also seen in numerous neurological diseases including stroke and Parkinson's disease, and it may co-occur with depression.
Source: The American Journal of Geriatric Psychiatry - October 22, 2022 Category: Geriatrics Authors: Stephanie Collier Tags: Editorial Source Type: research
Treatment of Vascular and Neurodegenerative Forms of Cognitive Impairment and Dementias
Ideally, dementia care should be provided by a collaborative team. Eligible patients should be treated with the cognitive-enhancing medications, the cholinesterase inhibitors and memantine. For most of the common causes of dementia, there are no disease-modifying medications, with the exception that vascular dementia can be prevented by treating vascular risk factors to prevent stroke. There is hope that Alzheimer disease can be treated by using monoclonal antibodies that target amyloid beta, although more trials are needed. Holistic, patient-centered care can enhance quality and extend the time that the patient can live s...
Source: Clinics in Geriatric Medicine - October 18, 2022 Category: Geriatrics Authors: Landon Perlett, Eric E. Smith Source Type: research
Antiplatelets and Vascular Dementia: A Systematic Review
J Aging Res. 2022 Sep 19;2022:9780067. doi: 10.1155/2022/9780067. eCollection 2022.ABSTRACTVascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology s...
Source: Journal of Aging Research - October 17, 2022 Category: Geriatrics Authors: Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla Source Type: research
Association of Delirium Incidence with Visitation Restrictions due to COVID-19 Pandemic in Patients with Acute Cerebrovascular Disease in a Stroke-Unit Setting: A Retrospective Cohort Study
Conclusion: Pandemic-associated visitation restrictions and specifically absolute visitation restrictions are associated with a higher incidence of delirium among stroke-unit patients with acute cerebrovascular disease. Benefit and harm of visitation restrictions should be carefully weighed and adjustments considered for patients otherwise at increased risk for delirium.Gerontology
Source: Gerontology - October 6, 2022 Category: Geriatrics Source Type: research
AHA News: People With Dementia May Be Less Likely to Receive an Advanced Treatment For Stroke
Title: AHA News: People With Dementia May Be Less Likely to Receive an Advanced Treatment For StrokeCategory: Health NewsCreated: 8/24/2022 12:00:00 AMLast Editorial Review: 8/24/2022 12:00:00 AM
Source: MedicineNet Alzheimer - August 24, 2022 Category: Geriatrics Source Type: news
Cognitive Impairment After Stroke and Treatment with Fluoxetine: A Planned Analysis of the AFFINITY Randomised Controlled Trial
Strokes increase the risk of cognitive impairment and dementia, and the risk of post-stroke cognitive decline does not subside with time.1 Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, display neuroprotective and neuro-regenerative properties in animal models of brain ischaemia,2 raising hope that their use could lessen the detrimental effects of stroke on cognition.
Source: The American Journal of Geriatric Psychiatry - August 19, 2022 Category: Geriatrics Authors: Osvaldo P. Almeida, Graeme J. Hankey, Andrew Ford, Christopher Etherton-Beer, Leon Flicker, Maree L. Hackett, AFFINITY Trial Collaboration Tags: Letter to the Editor Source Type: research
Association of Arterial Spin Labeling Parameters With Cognitive Decline, Vascular Events, and Mortality in a Memory-Clinic Sample
CONCLUSIONS: Higher baseline GM-sCoV of ASL was associated with a decline in memory and risk of cerebrovascular disease and vascular events, suggesting that cerebrovascular insufficiency may contribute to accelerated cognitive decline and worse clinical outcomes in memory clinic participants.PMID:35871110 | DOI:10.1016/j.jagp.2022.06.007
Source: Am J Geriatr Psychia... - July 23, 2022 Category: Geriatrics Authors: Bibek Gyanwali Henk Jmm Mutsaerts Chuen Seng Tan Omar Rajab Kaweilh Jan Petr Christopher Chen Saima Hilal Source Type: research
Increased regional white matter hyperintensity volume in objectively-defined subtle cognitive decline and mild cognitive impairment
Neurobiol Aging. 2022 Jun 16;118:1-8. doi: 10.1016/j.neurobiolaging.2022.06.002. Online ahead of print.ABSTRACTWhite matter hyperintensities (WMH), a marker of small vessel cerebrovascular disease, increase risk of developing mild cognitive impairment (MCI) and Alzheimer's disease (AD). Less is known about the extent and pattern of WMH in pre-MCI stages, such as among those with objectively-defined subtle cognitive decline (Obj-SCD). Five hundred and fifty-nine Alzheimer's Disease Neuroimaging Initiative participants (170 cognitively unimpaired [CU]; 83 Obj-SCD; 306 MCI) free of clinical dementia or stroke completed neurop...
Source: Neurobiology of Aging - July 9, 2022 Category: Geriatrics Authors: Amanda T Calcetas Kelsey R Thomas Emily C Edmonds Sophia L Holmqvist Lauren Edwards Maria Bordyug Lisa Delano-Wood Adam M Brickman Mark W Bondi Katherine J Bangen None For The Alzheimer's Disease Neuroimaging Initiative Source Type: research
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study
Biogerontology. 2022 Jun 24. doi: 10.1007/s10522-022-09969-8. Online ahead of print.ABSTRACTTo find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy and unhealthy older individuals. Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn's disease, malabsorption or kidney disease. Six single nucleotide polymorphisms (SNPs) with unknown function associated with ten human genes were identified as candidate healths...
Source: Biogerontology - June 24, 2022 Category: Geriatrics Authors: Nadine Saul Ineke Dhondt Mikko Kuokkanen Markus Perola Clara Verschuuren Brecht Wouters Henrik von Chrzanowski Winnok H De Vos Liesbet Temmerman Walter Luyten Aleksandra Ze čić Tim Loier Christian Schmitz-Linneweber Bart P Braeckman Source Type: research
