Filtered By:
Specialty: Drugs & Pharmacology
Condition: Dementia
This page shows you your search results in order of relevance. This is page number 7.
Order by Relevance | Date
Total 176 results found since Jan 2013.
Highlighting the protective or degenerative role of AMPK activators in dementia experimental models
CNS Neurol Disord Drug Targets. 2021 May 26. doi: 10.2174/1871527320666210526160214. Online ahead of print.ABSTRACTAMP-activated protein kinase (AMPK) is a serine/threonine kinase and a driving or deterrent factor in the development of neurodegenerative diseases and dementia. AMPK affects intracellular proteins like the mammalian target of rapamycin (mTOR). Peroxisome proliferator-activated receptor-γ coactivator 1-α (among others) contributes to a wide range of intracellular activities based on its downstream molecules such as energy balancing (ATP synthesis), extracellular inflammation, cell growth, and neuronal cell d...
Source: CNS and Neurological Disorders Drug Targets - May 27, 2021 Category: Drugs & Pharmacology Authors: Marjan Nikbakhtzadeh Fatemeh Shaerzadeh Ghorbangol Ashabi Source Type: research
Role of microbiota-derived short-chain fatty acids in nervous system disorders
Biomed Pharmacother. 2021 Jul;139:111661. doi: 10.1016/j.biopha.2021.111661. Epub 2021 May 8.ABSTRACTDuring the past decade, accumulating evidence from the research highlights the suggested effects of bacterial communities of the human gut microbiota and their metabolites on health and disease. In this regard, microbiota-derived metabolites and their receptors, beyond the immune system, maintain metabolism homeostasis, which is essential to maintain the host's health by balancing the utilization and intake of nutrients. It has been shown that gut bacterial dysbiosis can cause pathology and altered bacterial metabolites' fo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Rasoul Mirzaei Behnaz Bouzari Seyed Reza Hosseini-Fard Maryam Mazaheri Yaghoub Ahmadyousefi Milad Abdi Saba Jalalifar Zahra Karimitabar Ali Teimoori Hossein Keyvani Farhad Zamani Rasoul Yousefimashouf Sajad Karampoor Source Type: research
Dosing antipsychotics in special populations of patients with schizophrenia: Severe psychotic agitation, first psychotic episode and elderly patients
Expert Opin Pharmacother. 2021 Aug 2. doi: 10.1080/14656566.2021.1958781. Online ahead of print.ABSTRACTIntroduction: Antipsychotic (AP) dosing is well established in nonelderly patients with acute exacerbations of schizophrenia, but not in special populations.Areas covered: This review describes the AP dosing procedures that have been used in clinical studies for acute psychotic agitation, a first episode of psychosis (FEP), and elderly patients. AP dosing data was extracted from the databases of drug regulatory authorities, and from clinical studies available in the medical literature.Expert opinion: In acute psychotic a...
Source: Expert Opinion on Pharmacotherapy - August 2, 2021 Category: Drugs & Pharmacology Authors: Fay çal Mouaffak Florian Ferreri Julie Bourgin-Duchesnay Emmanuelle Baloche Olivier Blin Pierre Vandel Ricardo P Garay Pierre Vidailhet Emmanuelle Corruble Pierre-Michel Llorca Source Type: research
Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review
Eur J Pharmacol. 2021 Sep 10:174492. doi: 10.1016/j.ejphar.2021.174492. Online ahead of print.ABSTRACTNeurodegenerative disorders pose a significant health burden and imprint a debilitative impact on the quality of life. Importantly, aging is intricately intertwined with the progression of these disorders, and their prevalence increases with a rise in the aging population worldwide. In recent times, fisetin emerged as one of the potential miracle molecules to address neurobehavioral and cognitive abnormalities. These effects were attributed to its actions on several macromolecules and multiple molecular mechanisms. Fisetin...
Source: European Journal of Pharmacology - September 13, 2021 Category: Drugs & Pharmacology Authors: Ravula Arun Reddy Teegala Suraj Benerji Kalakotla Shanker Pasangulapati Jagadeesh Prasad Venkatesan Perumal Boyina Hemanth Kumar Source Type: research
The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
Conclusions: Our experiments show that quercetin can protect HBMECs from H/R, which contains promoting cell proliferation, cell migration and angiogenesis, reducing mitochondrial membrane potential damage and inhibiting cell apoptosis. This may be related to its antioxidation and inhibition of endoplasmic reticulum stress. At the same time, quercetin can increase the level of BBB connexin, suggesting that quercetin can maintain BBB integrity.
Source: Frontiers in Pharmacology - October 20, 2021 Category: Drugs & Pharmacology Source Type: research
Yi-Zhi-Fang-Dai Formula Exerts Neuroprotective Effects Against Pyroptosis and Blood –Brain Barrier–Glymphatic Dysfunctions to Prevent Amyloid-Beta Acute Accumulation After Cerebral Ischemia and Reperfusion in Rats
Conclusion: Our study indicated that YZFDF could exert neuroprotective effects on cerebral I/R injury and prevent Aβ acute accumulation in the brain after cerebral I/R associated with inhibiting neuroinflammation-related pyroptosis and BBB–glymphatic dysfunctions.
Source: Frontiers in Pharmacology - December 15, 2021 Category: Drugs & Pharmacology Source Type: research
Strategies for treatment of disease-associated dementia beyond Alzheimer disease: An update
Curr Neuropharmacol. 2022 Apr 11. doi: 10.2174/1570159X20666220411083922. Online ahead of print.ABSTRACTMemory, cognition, dementia, and neurodegeneration are complexly interlinked processes through various mechanistic pathways leading to a range of clinical outcomes. These are strongly associated with pathological conditions like Alzheimer's disease, Parkinson's disease, schizophrenia, stroke and are a growing concern for their timely diagnosis and management. Several cognition-enhancing interventions for management include non-pharmacological interventions like diet, exercise, and physical activity, while pharmacological...
Source: Current Neuropharmacology - April 12, 2022 Category: Drugs & Pharmacology Authors: Khan Sabiya Samim Gopal L Khatik Ashok K Datusalia Source Type: research
