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Specialty: Cardiology
Condition: Dementia

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Total 319 results found since Jan 2013.

Atrial fibrillation catheter ablation associated silent cerebral emboli: A narrative review
AbstractThe incidence of silent cerebral emboli (SCE) associated with atrial fibrillation catheter ablation (AFCA) is much higher than that of stroke/transient ischemic attack (TIA). Interventional electrophysiologists have been increasingly alerted to asymptomatic cerebral infarction over the years. Plentiful studies revealed that diagnostic definitions, detection modalities, energy sources, ablation strategies, perioperative anticoagulation regimens, and patient-related factors were associated with the risk of AFCA-associated SCE. Studies related to non-interventional procedures found that SCE may prompt stroke, cognitiv...
Source: Pacing and Clinical Electrophysiology : PACE - August 15, 2023 Category: Cardiology Authors: Jingrui Zhang, Songnan Li, Caihua Sang, Changsheng Ma Tags: INVITED REVIEW Source Type: research

Abstract 2: The Changing Face of Cardiac Surgery: Frailty, Age, and Adverse Outcomes Create a Mandate for Shared Decision Making Concurrent Session I Session A: Oral Abstract Presentations on Less is More
CONCLUSIONS We have identified increasing rates of elderly and frail patients with high-risk profiles referred for cardiac surgery. These patients experience higher rates of mortality and prolonged institutional care. We suggest this vulnerable patient population may benefit from the institution of a formalized shared decision making process to effectively communicate risks, benefits and alternatives to the planned procedure.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Gainer, R., Buth, K., David, J., Garson, R., Mufti, H., Hirsch, G. Tags: Concurrent Session I Session A: Oral Abstract Presentations on Less is More Source Type: research

The effects of hypertension on the cerebral circulation
Maintenance of brain function depends on a constant blood supply. Deficits in cerebral blood flow are linked to cognitive decline, and they have detrimental effects on the outcome of ischemia. Hypertension causes alterations in cerebral artery structure and function that can impair blood flow, particularly during an ischemic insult or during periods of low arterial pressure. This review will focus on the historical discoveries, novel developments, and knowledge gaps in 1) hypertensive cerebral artery remodeling, 2) vascular function with emphasis on myogenic reactivity and endothelium-dependent dilation, and 3) blood-brain...
Source: AJP: Heart and Circulatory Physiology - June 15, 2013 Category: Cardiology Authors: Pires, P. W., Dams Ramos, C. M., Matin, N., Dorrance, A. M. Tags: REVIEWS Source Type: research

Asymptomatic cervicocerebral atherosclerosis, intracranial vascular resistance and cognition: The AsIA-Neuropsychology Study
Conclusions: Carotid plaques and increased intracranial vascular resistance are independently associated with low cognitive functioning in Caucasian stroke and dementia-free subjects. We failed to find an independent association of intracranial large vessel stenosis with cognitive performance.Highlights:
Source: Atherosclerosis - September 26, 2013 Category: Cardiology Authors: Jorge López-Olóriz, Elena López-Cancio, Juan F. Arenillas, María Hernández, Marta Jiménez, Laura Dorado, Maite Barrios, Juan José Soriano-Raya, Júlia Miralbell, Cynthia Cáceres, Rosa Forés, Guillem Pera, Antoni Dávalos, Maria Mataró Tags: Clinical & Population Research - Imaging Measurement of Vessel Health Source Type: research

Subclinical atherosclerotic calcification and cognitive functioning in middle-aged adults: The CARDIA study
We examined the association of coronary artery and abdominal aortic calcified plaque (CAC and AAC, respectively) with cognitive functioning in middle-aged adults.Methods: This cross-sectional study included 2510 black and white adults (age: 43–55 years) without heart disease or stroke who completed a year 25 follow-up exam (2010–11) as part of the Coronary Artery Risk Development in Young Adults Study. CAC and AAC were measured with non-contrast computed tomography. Cognition was assessed with the Digit Symbol Substitution Test (DSST) (psychomotor speed), Stroop Test (executive function), and Rey Auditory Verbal Learni...
Source: Atherosclerosis - October 14, 2013 Category: Cardiology Authors: Jared P. Reis, Lenore J. Launer, James G. Terry, Catherine M. Loria, Adina Zeki Al Hazzouri, Stephen Sidney, Kristine Yaffe, David R. Jacobs, Christopher T. Whitlow, Na Zhu, J. Jeffrey Carr Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research

Abstract 70: Eplerenone Increases Dilation and the Diameter of Cerebral Penetrating Arterioles in Rats with Sustained Hypertension Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones
Hypertension is linked to dementia in humans, as well as remodeling and dysfunction in large cerebral arteries. The effects of hypertension on cerebral microvessels, such as penetrating arterioles (PenA), are still unknown. These arterioles are the bottlenecks bridging the pial circulation to the deep parenchymal microcirculation, and they are vital for neurovascular coupling and functional hyperemia. Mineralocorticoid receptor (MR) antagonism reverses hypertension-induced changes in large cerebral arteries. Thus, we hypothesized that MR antagonism will improve PenA dilation and structure in adult rats with sustained hyper...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones Source Type: research

Dementia Risk Spikes in Older Women after MI (CME/CE)
(MedPage Today) -- Having a history of heart attack without stroke doubled the threat of mild cognitive impairment and dementia, adding to the evidence linking heart disease and mental decline in older women, researchers found.
Source: MedPage Today Cardiovascular - December 19, 2013 Category: Cardiology Source Type: news

Association of cognitive dysfunction with cardiovascular disease events in elderly hypertensive patients
This study assesses whether presence of cognitive dysfunction can be a marker associated with the development of cardiovascular disease (CVD) events independent of ambulatory blood pressure (BP) or other indices of target organ damage (TOD) in elderly hypertensive patients. Methods:We recruited 585 hypertensive patients (mean age, 73 years; 41% men) who were ambulatory, lived independently, and were without clinically overt dementia. Cognitive function was assessed by Mini-Mental State Examination (MMSE) at baseline, and CVD events (coronary artery disease, stroke, congestive heart failure, and sudden death) were prospecti...
Source: Journal of Hypertension - January 20, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Cognition Source Type: research

Trajectories of the Framingham general cardiovascular risk profile in midlife and poor motor function later in life: The Whitehall II study
Conclusions: Cardiovascular risk early in midlife is associated with poor motor performances later in life. Vascular risk factors play an important and under-recognized role in motor function, independently of their impact on cognition, and suggest that better control of vascular risk factors in midlife may prevent physical impairment and disability in the elderly.
Source: International Journal of Cardiology - January 23, 2014 Category: Cardiology Authors: Alexis Elbaz, Martin J. Shipley, Hermann Nabi, Eric J. Brunner, Mika Kivimaki, Archana Singh-Manoux Tags: Original Articles Source Type: research

Applanation Tonometry in Mice: A Novel Noninvasive Technique to Assess Pulse Wave Velocity and Arterial Stiffness Arterial Stiffness
Arterial stiffening is the root cause of a range of cardiovascular complications, including myocardial infarction, left ventricular hypertrophy, stroke, renal failure, dementia, and death, and a hallmark of the aging process. The most important in vivo parameter of arterial stiffness is pulse wave velocity (PWV). Clinically, PWV is determined noninvasively using applanation tonometry. Unlike the clinical value of arterial stiffness and PWV, techniques to determine PWV in mice are scarce. The only way to determine aortic PWV noninvasively in the mouse is by using ultrasound echo Doppler velocimetry. It is a fast, efficient,...
Source: Hypertension - June 11, 2014 Category: Cardiology Authors: Leloup, A. J. A., Fransen, P., Van Hove, C. E., Demolder, M., De Keulenaer, G. W., Schrijvers, D. M. Tags: Other diagnostic testing, Other Research Arterial Stiffness Source Type: research

Treating hypertension in the very elderly--benefits, risks, and future directions, a focus on the hypertension in the very elderly trial
Although the number of individuals reaching 80 who are considered to be healthy is increasing, the very elderly are likely to have long-term conditions, to report symptoms and/or be taking at least one regular medication. The impact of antihypertensive treatment has to be taken into account in this context. The treatment regimen in Hypertension in the Very Elderly Trial with a goal blood pressure of <150/80 mmHg has been shown to provide benefits in terms of a reduction in risk of total mortality, stroke, and cardiovascular events with potential benefits and no evidence of increased risk for fracture, dementia, depressi...
Source: European Heart Journal - July 7, 2014 Category: Cardiology Authors: Peters, R., Beckett, N., McCormack, T., Fagard, R., Fletcher, A., Bulpitt, C. Tags: Clinical update Source Type: research

Genetic Discoveries in Atrial Fibrillation and Implications for Clinical Practice
Atrial fibrillation (AF) is a highly prevalent arrhythmia that represents an important burden on healthcare systems. The presence of AF is associated with an increased risk of conditions such stroke, heart failure and dementia. Further, AF is associated with increased mortality. Over the past half century, significant advances have been made in understanding the pathobiology of AF. Important among these have been the demonstration that AF is a heritable disease and the identification of genetic variants underlying AF.
Source: Radcliffe Cardiology - August 17, 2014 Category: Cardiology Authors: admin Source Type: research

Resveratrol attenuated homocysteine-induced apoptosis of neonatal ventricular myocytes
Elevated homocysteine level in the plasma is a new independent important risk factor of ischemic heart diseases, stroke, dementia, Alzheimer's disease, renal failure, osteoporotic fracture, etc. In particularly, increasing evidence has revealed a strong association of hyperhyomocystemia with cardiovascular diseases including heart failure, atria fibrillation and venous thromboembolism, so that serum homocysteine level has been considered as a diagnostic marker of myocardial infraction and an important predictor of mortality for patients with coronary artery diseases (CAD) [1].
Source: International Journal of Cardiology - September 24, 2014 Category: Cardiology Authors: Yu Liu, Qiujia Shen, Qiaojing Liu, Zhina Hu, Xiaofeng Jiang Tags: Letters to the Editor Source Type: research

Resveratrol attenuated homocysteine-induced apoptosis of rat ventricular myocytes
Elevated homocysteine level in the plasma is a new independent important risk factor of ischemic heart diseases, stroke, dementia, Alzheimer's disease, renal failure, osteoporotic fracture, etc. In particular, increasing evidence has revealed a strong association of hyperhyomocystemia with cardiovascular diseases including heart failure, atrial fibrillation and venous thromboembolism, so that serum homocysteine level has been considered as a diagnostic marker of myocardial infraction and an important predictor of mortality for patients with coronary artery diseases (CAD) [1].
Source: International Journal of Cardiology - September 24, 2014 Category: Cardiology Authors: Yu Liu, Qiaojing Liu, Zhina Hu, Qiujia Shen, Hongyan Liang, Xiaofeng Jiang Tags: Letter to the Editor Source Type: research

Values of ambulatory blood pressure monitoring for prediction of cognitive function impairment in elderly hypertensive patients
Conclusion The study demonstrated that hypertensive patients diagnosed by ABPM have significantly more impaired cognitive function than control subjects as proved by the mini-mental state examination and brain MRI score of white matter disease.
Source: The Egyptian Heart Journal - November 6, 2014 Category: Cardiology Source Type: research