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Total 3025 results found since Jan 2013.

Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer & rsquo;s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids Molecules doi: 10.3390/molecules28155624 Authors: Ryszard Pluta Barbara Miziak Stanisław J. Czuczwar Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation, oxidative stress, vasoconstriction, cerebral amyloid angiopathy,...
Source: Molecules - July 25, 2023 Category: Chemistry Authors: Ryszard Pluta Barbara Miziak Stanis ław J. Czuczwar Tags: Review Source Type: research

Roche enters partnership with Alnylam to co-develop and co-commercialise RNAi therapeutic zilebesiran to treat hypertension in patients with high cardiovascular risk
Partnership combines Roche ’s proven track record of successfully developing and launching innovative medicines worldwide withAlnylam ’s leadership in RNAi therapeuticsZilebesiran, a Phase 2 RNAi therapeutic, has best-in-disease potential for patients with hypertension at high risk of cardiovascular morbidity and mortality, by robustly and durably lowering blood pressureHypertension, the leading cause of cardiovascular disease, affects more than 1.2 billion adults worldwide. While several therapies exist, a significant unmet need, especially for high risk patients, remains.1Basel, 24 July 2023 - Roche (SIX: RO, ROG; OT...
Source: Roche Media News - July 24, 2023 Category: Pharmaceuticals Source Type: news

Relationship Between Direct Oral Anticoagulant Doses and Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation 　- ANAFIE Registry Sub-Analysis
CONCLUSIONS: Inappropriate low DOAC doses (under- or off-label dose) were not associated with stroke/SEE or major bleeding but were associated with all-cause death.PMID:37482411 | DOI:10.1253/circj.CJ-23-0143
Source: Circulation Journal - July 23, 2023 Category: Cardiology Authors: Masaharu Akao Hiroshi Inoue Takeshi Yamashita Hirotsugu Atarashi Takanori Ikeda Yukihiro Koretsune Ken Okumura Shinya Suzuki Hiroyuki Tsutsui Kazunori Toyoda Atsushi Hirayama Masahiro Yasaka Takenori Yamaguchi Satoshi Teramukai Tetsuya Kimura Yoshiyuki Mo Source Type: research

Clustering populations by health and social care with multiple long-term conditions: a cohort study - the English Longitudinal Study of Ageing (ELSA)
CONCLUSION: This study identified MLTC clusters by social care need with the highest primary care demand. Targeting clinical practice to prevent MLTC progression for these groups may lessen future pressures on primary care demand.PMID:37479312 | DOI:10.3399/bjgp23X734337
Source: The British Journal of General Practice - July 21, 2023 Category: Primary Care Authors: Hajira Dambha-Miller Yvonne Nartey Nusrat Khan Glenn Simpson Sharon Lin Ralph Akyea Andrew Farmer Source Type: research

Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults
CONCLUSIONS AND RELEVANCE: This study found that better sleep consolidation and the absence of OSA were associated with better global cognition over 5 years of follow-up. These findings suggest that the role of interventions to improve sleep for maintaining cognitive function requires investigation.PMID:37462968 | DOI:10.1001/jamanetworkopen.2023.25152
Source: Atherosclerosis - July 18, 2023 Category: Cardiology Authors: Matthew P Pase Stephanie Harrison Jeffrey R Misialek Christopher E Kline Marina Cavuoto Andree-Ann Baril Stephanie Yiallourou Alycia Bisson Dibya Himali Yue Leng Qiong Yang Sudha Seshadri Alexa Beiser Rebecca F Gottesman Susan Redline Oscar Lopez Pamela L Source Type: research

Scientists Are Just Beginning to Understand COVID-19 ’ s Effect On the Brain
Early in the COVID-19 pandemic, doctors started to notice something striking. For what was originally described as a respiratory virus, SARS-CoV-2 seemed to have a strong effect on the brain, causing everything from loss of taste and smell and brain fog to, in serious cases, stroke. NYU Langone Health, a New York city research hospital, started collating those anecdotes in hopes of better understanding how the virus affects the brain and nervous system. Years later, the project has morphed from focusing solely on acute symptoms to also tracking the long-term neurologic issues that some people with Long COVID experience, sa...
Source: TIME: Health - July 17, 2023 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study
ConclusionMemTrax (MTx) is valid and effective for screening for PSCI among target patients and is a potentially valuable and practical tool in the clinical follow-up, monitoring, and case management of PSCI.
Source: Frontiers in Human Neuroscience - July 17, 2023 Category: Neuroscience Source Type: research

Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients
Conclusions In this large ‘real-world’ cohort, outcomes after mechanical thrombectomy were strongly associated with age. Of patients aged ≥80 years more than half were dead and less than one-fifth were functionally independent at 1 year. Certain comorbidities and ventilation >48 hours were associated with even worse outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2023 Category: Neurosurgery Authors: Beuker, C., Köppe, J., Feld, J., Meyer, C. L., Dröge, P., Ruhnke, T., Günster, C., Wiendl, H., Reinecke, H., Minnerup, J. Tags: Open access Cerebrovascular disease Source Type: research

Exploring the occurrence and the risk factors of the desire for hastened death and depression in people with early-stage dementia in Greece
Palliat Support Care. 2023 Jul 10:1-9. doi: 10.1017/S1478951523001062. Online ahead of print.ABSTRACTOBJECTIVES: To assess the factors associated with desire for hastened death and depression in early-stage dementia as well as the association between them. Also, to explore the mediator and moderator role of age in the relationship between depression and desire for hasten death.METHODS: A prospective cross-sectional study including 100 patients diagnosed with early-stage dementia from a rehabilitation center between December 2018 and July 2019. Measurement tools used were the Mini-Mental State Examination, the Greek Montrea...
Source: Palliative and Supportive Care - July 10, 2023 Category: Palliative Care Authors: Sotiria Kostopoulou Athina Pinelopi Varveri Maria Nikoloudi Eleni Tsilika Efi Parpa Anna Zygogianni Kyriaki Mystakidou Source Type: research