• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Ketogenic Diet as a Treatment for Super-Refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome
Conclusions: The characteristic EEG pattern in the acute phase promoted timely diagnosis of FIRES. Our data suggest that KD may be a safe and promising therapy for FIRES with SRSE, and that early initiation of KD produces a favorable prognosis. Therefore, KD should be applied earlier in the course of FIRES. Intravenous KD can be an effective alternative route of administration for patients who may not take KD enterally. Introduction Febrile infection-related epilepsy syndrome (FIRES) is a rare epileptic encephalopathy of unknown etiology which occurs in patients without active epilepsy or underlying neurological diso...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Mast cells in mastocytosis and allergy – Important player in metabolic and immunological homeostasis
Publication date: March 2019Source: Advances in Medical Sciences, Volume 64, Issue 1Author(s): Joanna Renke, Sabina Kędzierska-Mieszkowska, Magdalena Lange, Bogusław Nedoszytko, Eliza Wasilewska, Anna Liberek, Marcin Renke, Marek Niedoszytko, Jacek Witkowski, Joanna Skórko-Glonek, Barbara LipińskaAbstractThe role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell m...
Source: Advances in Medical Sciences - January 13, 2019 Category: Biomedical Science Source Type: research

Mast cells in mastocytosis and allergy - Important player in metabolic and immunological homeostasis.
Abstract The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Mastocytosis is a heterogeneous group of disorders characterized by accumulation of MC in one or more organs. There are s...
Source: Advances in Medical Sciences - January 11, 2019 Category: Biomedical Science Authors: Renke J, Kędzierska-Mieszkowska S, Lange M, Nedoszytko B, Wasilewska E, Liberek A, Renke M, Niedoszytko M, Witkowski J, Skórko-Glonek J, Lipińska B Tags: Adv Med Sci Source Type: research

Republished: Recent advances in autoimmune pancreatitis: type 1 and type 2
Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis characterised clinically by frequent presentation with obstructive jaundice, histologically by a lymphoplasmacytic infiltrate with fibrosis, and therapeutically by a dramatic response to steroids. When so defined, AIP can be sub-classified into two subtypes, 1 and 2. Recent international consensus diagnostic criteria for AIP have been developed for diagnosis of both forms of AIP. Type 1 AIP is the pancreatic manifestation of a multiorgan disease, recently named IgG4-related disease. Little is known about the pathogenesis of either form of AIP. Despite frequent...
Source: Postgraduate Medical Journal - December 11, 2013 Category: Journals (General) Authors: Kamisawa, T., Chari, S. T., Lerch, M. M., Kim, M.-H., Gress, T. M., Shimosegawa, T. Tags: GUT Recent advances in clinical practice, Pancreas and biliary tract, Pancreatitis, Immunology (including allergy) Republished recent advances in clinical practice Source Type: research

Relevance of gad antibodies in adults with epilepsy: experience in a tertiary clinic
Conclusion Our experience suggests that GAD antibodies are present in a significant number of patients with adult onset epilepsy, especially those with other autoimmune disorders. The relevance of GAD antibodies in this setting remains unclear. The presence of OCBs and GAD antibodies within the CSF suggest a CNS based autoimmune process but the GAD antibodies themselves may be a marker of this processes rather than being directly pathogenic, as is suggested for antibodies directed against neuronal surface antigens. In our cohort immunotherapy did not improve seizure control and it may be that these antibodies are produced ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lilleker, J., Biswas, V., Mohanraj, R. Tags: Immunology (including allergy), Brain stem / cerebellum, Cranial nerves, Drugs: CNS (not psychiatric), Epilepsy and seizures, Neuromuscular disease, Peripheral nerve disease, Ophthalmology, Radiology, Connective tissue disease, Musculoskeletal syndromes, Source Type: research