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Condition: Autism
Drug: Melatonin
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Total 87 results found since Jan 2013.
An Overview of Pharmacotherapy in the Management of Children with Autism Spectrum Disorder at a Public Hospital in KwaZulu-Natal
This study presents an overview of prescribing patterns and provides insight into the current management practice for the core symptoms and comorbidities of ASD in children. A quantitative retrospective study was conducted at a public hospital in KwaZulu-Natal, South Africa by reviewing patient files of children diagnosed with ASD and meeting the inclusion criteria for the study. A descriptive analysis of data was done to identify treatment trends and patient therapeutic outcomes. A total of 181 children met the inclusion criteria of the study. Risperidone was the most frequently prescribed drug (88%) for the management of...
Source: Child Psychiatry and Human Development - March 22, 2023 Category: Child Development Authors: Jennal Maniram Frasia Oosthuizen Saira B S Karrim Source Type: research
Sleep Problems, Circadian Rhythms, and Their Relation to Behavioral Difficulties in Children and Adolescents with Autism Spectrum Disorder
J Autism Dev Disord. 2023 Mar 4. doi: 10.1007/s10803-023-05934-7. Online ahead of print.ABSTRACTThis was an exploratory cross-sectional study comparing 45 children with ASD to 24 typically developing drug-naïve controls, group-matched on age, sex, and body mass index. Objective data was obtained using the following: an ambulatory circadian monitoring device; saliva samples to determine dim light melatonin onset (DLMO): and three parent-completed measures: the Child Behavior Checklist (CBCL); the Repetitive Behavior Scale-Revised (RBS-R); and the General Health Questionnaire (GHQ28). The CBCL and RBS-R scales showed the hi...
Source: Journal of Autism and Developmental Disorders - March 4, 2023 Category: Psychiatry Authors: Elena Martinez-Cayuelas Teresa Gavela-P érez Mar ía Rodrigo-Moreno Rebeca Losada-Del Pozo Beatriz Moreno-Vinues Carmen Garces Leandro Soriano-Guill én Source Type: research
Continuous positive airway pressure as an accurate marker for non-24-hour sleep-wake rhythm disorder
We report the case of a 46-year-old man with autism spectrum disorder (ASD) and agoraphobia who had been referred for a suspicion of obstructive sleep apnea syndrome (OSAS). Polysomnography and arterial blood gas confirmed moderate OSAS associated with hypoventilation. Continuous positive airway pressure (CPAP) was started on fixed mode with excellent results. At follow-up, his CPAP report data revealed an irregular sleep-wake rhythm with a progressive offset of sleep schedule and wake time delayed from 1 h from day to day. Melatonin (or agonist) is efficacious and safe for long-term treatment in ASD and circadian rhythm s...
Source: Journal of Sleep Research - February 17, 2023 Category: Sleep Medicine Authors: Balthazar Bazin Pierre A Geoffroy H élène Benzaquen Julia Maruani Alix Romier Michel Lejoyeux Marie-Pia D'ortho Justine Frija-Masson Source Type: research
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism
Biomed Pharmacother. 2022 Dec;156:113949. doi: 10.1016/j.biopha.2022.113949. Epub 2022 Nov 1.ABSTRACTAutism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a rapidly increasing global prevalence. Early unstable and immature microbiota are often observed in ASD patients, resulting in neurobehavioral dysfunction. Since the establishment of stable gut microbiota in early life falls into the same critical time window as neurodevelopment, manipulations of the gut microbiota during early life could become a promising strategy for ASD. Melatonin is an endogenous hormone and can restore gut microbial dysbiosi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2022 Category: Drugs & Pharmacology Authors: Xia Liu Yi Cui Yuhan Zhang Guo Xiang Meng Yu Xianshu Wang Bin Qiu Xin-Gang Li Wei Liu Di Zhang Source Type: research
Melatonin usage in children and young adults, a registry-based cohort study
Eur J Paediatr Neurol. 2022 May 25;39:30-34. doi: 10.1016/j.ejpn.2022.05.007. Online ahead of print.ABSTRACTSleep disorder is common in children and adolescents, particularly in those with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD). While non-pharmacological treatment is first line, occasionally an add-on of an oral drug is needed. The endogenous hormone melatonin is increasingly used for sleep disorders in children and adolescents. In this registry-based cohort study we follow dispensation of melatonin in young individuals, 0-25 years of age, in Stockholm, Sweden during 2016-2019. In...
Source: European Journal of Paediatric Neurology - May 31, 2022 Category: Neurology Authors: K Tedroff M von Euler E Dahl én Source Type: research
The Effects of Vitamin Therapy on ASD and ADHD: A Narrative review
CNS Neurol Disord Drug Targets. 2022 May 17. doi: 10.2174/1871527321666220517205813. Online ahead of print.ABSTRACTThe effects of a sufficient amounts of vitamins and nutrients on the proper function of the nervous system have always been regarded by scientists. In recent years, there are many studies have been done on controling or improving the symptoms of neurological and behavioral disorders which is created by changes in the level of vitamins and other nutrition, such as omega-3 and iron supplements. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that causes disruption individual communication, especi...
Source: CNS and Neurological Disorders Drug Targets - May 19, 2022 Category: Drugs & Pharmacology Authors: Mohadeseh Poudineh Sadaf Parvin Mehrnia Omidali Farhad Nikzad Fatemeh Mohammadyari Fatemeh Sadeghi Poor Ranjbar Fayaz Rasouli Sepehr Nanbakhsh Sepehr Olangian-Tehrani Source Type: research
