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Condition: Thrombocytopenia

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Total 366 results found since Jan 2013.

Cerebral Venous Thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine
We report two cases of cerebral venous thrombosis, shortly after administration of mRNA vaccine. In both patients, there was no evidence of thrombocytopenia or antiplatelet antibodies, and alternative causes for cerebral venous thrombosis were found.
Source: Journal of Stroke and Cerebrovascular Diseases - May 25, 2021 Category: Neurology Authors: Leonor Dias, Ricardo Soares-dos-Reis, Jo ão Meira, Diana Ferrão, Pedro Ribeirinho Soares, Ana Pastor, Guilherme Gama, Luísa Fonseca, Vítor Fagundes, Marta Carvalho Source Type: research

Thrombocytopenia with acute ischemic stroke and bleeding in a patient newly vaccinated with an adenoviral vector-based COVID-19 vaccine: COMMENT: COMMENT from Gruel et al.: RESPONSE from Kahn et al
J Thromb Haemost. 2021 Jul 17. doi: 10.1111/jth.15467. Online ahead of print.ABSTRACTWe acknowledge the commentary of Gruel et al. on our recent letter [1] and are pleased that the authors agree that IdeS may be a potential treatment option for the rare but potentially severe IgG-mediated platelet activation observed in complications to vaccination with ChAdOx1 nCoV-19. It is apparent that our respective but distinct expertise with regard to IdeS has led us to develop this hypothesis in parallel. As we clearly cited in our original letter these authors have previously contributed important evidence that IdeS may be benefic...
Source: Thrombosis and Haemostasis - July 17, 2021 Category: Hematology Authors: Fredrik Kahn Oongh Shannon Lars Bj örck Source Type: research

Complement dysregulation is associated with severe COVID-19 illness
Haematologica. 2021 Jul 22. doi: 10.3324/haematol.2021.279155. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement-mediated diseases. Multiple clinical and preclinical studies have implicated complement in the pathogenesis of COVID-19 illness. We previously found that the SARS-CoV-2 spike protein activates the alternative pathway of complement (APC) in vitro through interfering with the function of complement factor H, a key negative regulator of APC. Here, w...
Source: Haematologica - July 22, 2021 Category: Hematology Authors: Jia Yu Gloria F Gerber Hang Chen Xuan Yuan Shruti Chaturvedi Evan M Braunstein Robert A Brodsky Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions: Ideal ischemia time is 20-25 minutes or less improves short and long term renal function. >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR. No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The opening question ...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news

A case series analysis on the clinical experience of Impella 5.5 ® at a large tertiary care centre
ConclusionsIn this early experience of the pVAD 5.5, procedural and device-related complications were observed but were manageable, and overall survival was high in this critically ill cohort, particularly when the device was used as a bridge to other therapies.
Source: ESC Heart Failure - August 17, 2021 Category: Cardiology Authors: Peter J. Kennel, Heidi Lumish, Yuji Kaku, Justin Fried, Ajay J. Kirtane, Dimitri Karmpaliotis, Hiroo Takayama, Yoshifumi Naka, Gabriel Sayer, Nir Uriel, Koji Takeda, Amirali Masoumi Tags: Original Research Article Source Type: research

Vaccine-Induced Immune Thrombotic Thrombocytopenia with Disseminated Intravascular Coagulation and Death following the ChAdOx1 nCoV-19 Vaccine
We report a fatal case of vaccine-induced immune thrombotic thrombocytopenia (VITT) after receiving the first dose of the ChAdOx1 nCoV-19 vaccine.
Source: Journal of Stroke and Cerebrovascular Diseases - June 22, 2021 Category: Neurology Authors: Yasser Aladdin, Hussein Algahtani, Bader Shirah Tags: Case Report Source Type: research

Neuro ‐COVID‐19
AbstractNeuromuscular manifestations of new coronavirus infection (COVID-19) are frequent and include dizziness, headache, myopathy, and olfactory and gustatory disturbances. Patients with acute central nervous system (CNS) disorders, such as delirium, impaired consciousness, stroke, and convulsive seizures, have a high mortality rate. The encephalitis/encephalopathy that causes consciousness disturbance and seizures can be classified into three conditions, including direct infection with the SARS-CoV-2 virus, encephalopathy caused by CNS damage secondary to systemic hypercytokinemia (cytokine storm), and autoimmune-mediat...
Source: Clinical and Experimental Neuroimmunology - September 12, 2021 Category: Neurology Authors: Takayoshi Shimohata Tags: REVIEW ARTICLE Source Type: research

Hematologic Emergencies in the Postoperative Neurointensive Care Unit Setting: Illustrative Case Series and Differential Diagnosis
Disseminated intravascular coagulation (DIC), a consumptive coagulopathy, occurs as a complication of various conditions. The coagulation pathway is activated leading to formation of fibrin clots that are then released into the circulation. This results in ischemia and subsequent organ failure along with simultaneous consumption of platelets and coagulation factors leading to hemorrhage.1 Diagnostic criteria for DIC include thrombocytopenia, prolonged prothrombin time, reduced fibrinogen levels, and increase in fibrinogen degradation products.
Source: Journal of Stroke and Cerebrovascular Diseases - August 3, 2021 Category: Neurology Authors: Rana Hanna Al Shaikh, Oluwaseun O. Akinduro, Tasneem F. Hasan, Seung Jin Lee, Ernesto Ayala, Alfredo E. Quinones-Hinojosa, Kristin A. Cushenbery, Julie E. Hammack, Jang Won Yoon, Dennis W. Dickson, William D. Freeman Source Type: research

Cervicocerebral atherosclerosis and its hepatic and coronary risk factors in patients with liver cirrhosis
CONCLUSIONS: Our data suggest that LC confers protection against intracranial atherosclerosis, and that thrombocytopenia may be involved in this protection. High CAC score could serve as a potential surrogate for cervicocerebral vascular screening in asymptomatic cirrhotics.PMID:34637612 | DOI:10.3350/cmh.2021.0202
Source: Clinical and molecular hepatology - October 12, 2021 Category: Gastroenterology Authors: Jihyun An Hyung Don Kim Seon-Ok Kim Ha Il Kim Gi-Won Song Han Chu Lee Ju Hyun Shim Source Type: research

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