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Condition: Spinal Cord Injury

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Amiloride Analogs as ASIC1a Inhibitors.
CONCLUSION: Addition of a benzyl group to the terminal guanidinyl group resulted in enhanced inhibitory activity on ASIC1a. On the other hand, the bulky groups added to the 5-amino residues slightly decreased the activity. Among the tested amiloride analogs, benzamil is the most potent ASIC1a inhibitor. PMID: 26890278 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - February 18, 2016 Category: Neuroscience Authors: Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG Tags: CNS Neurosci Ther Source Type: research

Delivering neurocritical care in resource-challenged environments
Purpose of review: Resource-challenged environments of low and middle-income countries face a significant burden of neurocritical illness. This review attempts to elaborate on the multiple barriers to delivering neurocritical care in these settings and the possible solutions to overcome such barriers. Recent findings: Epidemiology of neurocritical illness appears to have changed over time in low and middle-income countries. In addition to neuro-infection, noncommunicable neurological illnesses like stroke, traumatic brain injury, and traumatic spinal cord injury pose a significant neurocritical burden in resource-limited ...
Source: Current Opinion in Critical Care - March 6, 2016 Category: Nursing Tags: NEUROSCIENCE: Edited by J. Claude Hemphill Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Susceptibility‐weighted imaging: current status and future directions
Susceptibility‐weighted imaging (SWI) is a method that uses the intrinsic nature of local magnetic fields to enhance image contrast in order to improve the visibility of various susceptibility sources and to facilitate diagnostic interpretation. It is also the precursor to the concept of the use of phase for quantitative susceptibility mapping (QSM). Nowadays, SWI has become a widely used clinical tool to image deoxyhemoglobin in veins, iron deposition in the brain, hemorrhages, microbleeds and calcification. In this article, we review the basics of SWI, including data acquisition, data reconstruction and post‐processi...
Source: NMR in Biomedicine - April 30, 2016 Category: Radiology Authors: Saifeng Liu, Sagar Buch, Yongsheng Chen, Hyun‐Seok Choi, Yongming Dai, Charbel Habib, Jiani Hu, Joon‐Yong Jung, Yu Luo, David Utriainen, Meiyun Wang, Dongmei Wu, Shuang Xia, E. Mark Haacke Tags: Special issue review article Source Type: research

Vodafone to connect Ekso rehab exoskeletons to the IoT
Robotic exoskeletons designed for rehabilitation from Ekso Bionics (OTCBB:EKSO) are being upgraded with a connection to the “Internet of Things” from Vodafone, the companies said today. The Ekso GT, which Vodafone said is the 1st and only exoskeleton cleared by the FDA for use with both stroke patients and spinal cord injuries, will be upgraded to connect to Vodafone’s network and global IoT to “ensure reliable communications for diagnostics and improved access to patient data.” “The Internet of Things is enabling all types of medical devices to be connected anywhere in the world, whic...
Source: Mass Device - June 7, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Prosthetics Ekso Bionics Vodafone Group Source Type: news

FDA OKs expansion of InVivo Therapeutics spinal scaffold study
InVivo Therapeutics (NSDQ:NVIV) said today that the FDA cleared an expansion of its Inspire study of its neuro-spinal scaffold, now set to enroll up to 20 patients, and announced the 9th and 10th implantation in the trial, though the 10th patient died of an unrelated stroke. The Cambridge, Mass.-based company’s neuro-spinal scaffold is surgically implanted following acute spinal cord injuries to act as a physical substrate for nerve sprouting. The federal watchdog cleared the company to expand the trial for up to 20 evaluable patients. The decision came based off the review of 6-month safety data from the trial, InViv...
Source: Mass Device - July 12, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Clinical Trials Spinal InVivo Therapeutics Corp. Source Type: news

Susceptibility ‐weighted imaging: current status and future directions
Susceptibility‐weighted imaging (SWI) is a method that uses the intrinsic nature of local magnetic fields to enhance image contrast in order to improve the visibility of various susceptibility sources and to facilitate diagnostic interpretation. It is also the precursor to the concept of the use of phase for quantitative susceptibility mapping (QSM). Nowadays, SWI has become a widely used clinical tool to image deoxyhemoglobin in veins, iron deposition in the brain, hemorrhages, microbleeds and calcification. In this article, we review the basics of SWI, including data acquisition, data reconstruction and post‐processi...
Source: NMR in Biomedicine - May 17, 2016 Category: Radiology Authors: Saifeng Liu, Sagar Buch, Yongsheng Chen, Hyun ‐Seok Choi, Yongming Dai, Charbel Habib, Jiani Hu, Joon‐Yong Jung, Yu Luo, David Utriainen, Meiyun Wang, Dongmei Wu, Shuang Xia, E. Mark Haacke Tags: Special issue review article Source Type: research

Paraplegics Regain Some Feeling, Movement After Using Brain-Machine Interfaces
This study was funded by grants from the Brazilian Financing Agency for Studies and Projects (FINEP 01 ·12·0514·00), Brazilian Ministry of Science, Technology and Innovation, and the Itaú Bank. The authors list additional acknowledgements in the manuscript. They declared no competing financial interests related to this work.###
Source: DukeHealth.org: Duke Health Features - August 11, 2016 Category: Pediatrics Tags: Duke Medicine Source Type: news

Total aortic arch repair: risk factor analysis and follow-up in 199 patients AORTIC SURGERY
CONCLUSIONS Aortic arch repair remains a high-risk procedure, especially in multisegment aortic disease. Several peri- and postoperative factors predicted adverse outcome, indicating the need to further improve perioperative management (e.g. organ protection). Indications for FET treatment have to be thoroughly investigated (e.g. FET in CDs).
Source: European Journal of Cardio-Thoracic Surgery - November 3, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Martens, A., Beckmann, E., Kaufeld, T., Umminger, J., Fleissner, F., Koigeldiyev, N., Krueger, H., Puntigam, J., Haverich, A., Shrestha, M. Tags: Extracorporeal circulation, Vascular malformations AORTIC SURGERY Source Type: research

Transcranial and spinal cord magnetic stimulation in treatment of spasticity. A literature review and meta--analysis.
CONCLUSIONS: According to the meta-analysis, the statistically significant effect of TMS in the form of reduced spasticity was demonstrated only for the developed due to lesions at the brain stem and spinal cord level. To clarify the amount of the antispasmodic effect of repetitive TMS at other lesion levels, in particular in patients with hemispheric stroke, further research is required. PMID: 28004906 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - December 21, 2016 Category: Rehabilitation Authors: Korzhova J, Sinitsyn D, Chervyakov A, Poydasheva A, Zakharova M, Suponeva N, Chernikova L, Piradov M Tags: Eur J Phys Rehabil Med Source Type: research

Layoffs ahead for ReWalk Robotics
ReWalk Robotics (NSDQ:RWLK) is reportedly planning to cut its operating expenses by 30% in 2017, a move that’s slated to include layoffs for an unspecified number of workers. The Marlborough, Mass.- and Israel-based company said it aims to meet its goal partially via a “reduction in staffing.” ReWalk had 87 employees as of December 2015, according to a regulator filing. “In the years since ReWalk received its FDA clearances for spinal cord-injured individuals, we have seen the market evolve, albeit slowly,” CEO Larry Jasinski said in prepared remarks. “Taking an industry-wide assessme...
Source: Mass Device - January 11, 2017 Category: Medical Equipment Authors: Sarah Faulkner Tags: Prosthetics Robotics Wall Street Beat ReWalk Robotics Source Type: news

Comparative study of therapeutic response to baclofen vs tolperisone in spasticity.
In this study we compared the efficacy and safety of baclofen vs tolperisone in spasticity. One hundred fifty patients with cerebral palsy or post stroke or spinal cord injury associated spasticity were enrolled in present study. Group I comprised of Seventy-five patients receiving baclofen and group II comprised of 75 patients receiving tolperisone. For efficacy measurement 4 evaluation methods were used, 1) Modified Ashworth Scale for muscle tone, 2) Medical research council scale for muscle strength and 3) Barthel Index for functional outcome 4) Coefficient of efficacy. In efficacy evaluation, both groups showed signifi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 9, 2017 Category: Drugs & Pharmacology Authors: Agarwal S, Patel T, Shah N, Patel BM Tags: Biomed Pharmacother Source Type: research

Why Do We Choose To Survive After Tragedy?
Why did my brother warn me against reading this book? It’s so good! I thought to myself, as I quickly devoured the pages of JoJo Moyes bestseller titled Me Before You. It was an uplifting tale about a young man who rediscovers love and laughter after a devastating spinal cord injury left him in a dangerous pool of depression. Finding myself at times in my own, albeit more shallow, pool of depression, I knew this story was exactly what I needed to remind me that I could find meaning in my life after my stroke. As I continued reading, anticipating the feel-good happy ending with a girl saving the boy's life with the power ...
Source: Healthy Living - The Huffington Post - May 17, 2017 Category: Consumer Health News Source Type: news

Myomo wins CE Mark for next-gen MyoPro powered orthotic
Myomo said today it won CE Mark approval in the European Union for its next-gen MyoPro myoelectric arm orthosis device. Cambridge, Mass.-based Myomo develops and produces myoelectric orthotics for patients with neuromuscular disorders, including its flagship MyoPro line. The orthosis devices are non-invasive, powered braces used to support weak or deformed arms and hands to allow for functional activity. Myomo touted the MyoPro as the only lightweight wearable device designed to restore function to paralyzed or weakened arms and hands in individuals who have suffered a stroke, spinal cord or nerve injury or other neuromus...
Source: Mass Device - July 31, 2017 Category: Medical Devices Authors: Fink Densford Tags: Blog Myomo Inc Source Type: news