Amiloride Analogs as ASIC1a Inhibitors.

CONCLUSION: Addition of a benzyl group to the terminal guanidinyl group resulted in enhanced inhibitory activity on ASIC1a. On the other hand, the bulky groups added to the 5-amino residues slightly decreased the activity. Among the tested amiloride analogs, benzamil is the most potent ASIC1a inhibitor. PMID: 26890278 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26890278?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 18, 2016 Category: Neuroscience Authors: Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG Tags: CNS Neurosci Ther Source Type: research