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Condition: Spinal Cord Injury

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Total 1255 results found since Jan 2013.

Herpes simplex virus infection and erectile dysfunction: a nationwide population‐based study
In conclusion, HSV infections were associated with risk of ED in this cohort.
Source: International Journal of Andrology - December 14, 2012 Category: Sexual Medicine Authors: C.‐C. Huang, W.‐L. Chan, Y.‐C. Chen, T.‐J. Chen, C.‐M. Chung, P.‐H. Huang, S.‐J. Lin, J.‐W. Chen, H.‐B. Leu Tags: Original Article Source Type: research

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news

Herpes simplex virus infection and erectile dysfunction: a nationwide population-based study.
In conclusion, HSV infections were associated with risk of ED in this cohort. PMID: 23413136 [PubMed - in process]
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Huang CC, Chan WL, Chen YC, Chen TJ, Chung CM, Huang PH, Lin SJ, Chen JW, Leu HB Tags: Andrology Source Type: research

Neurons in the brain switch identity and re-route fibres | Mo Costandi
New findings could one day lead to gene therapies for stroke and spinal cord injuriesThese drawings by Santiago Ramón y Cajal show the cellular structure of three different areas of the human cerebral cortex. The cortex is the seat of higher mental functions such as language and decision-making, and contains dozens of distinct, specialised areas. As Cajal's drawings show, it has a characteristic layered structure, which differs somewhat from one area to the next, so that the layers vary in thickness according to the number of cells they contain. Cells throughout the cortex are arranged in a highly ordered manner. Those in...
Source: Guardian Unlimited Science - February 26, 2013 Category: Science Tags: Blogposts Health guardian.co.uk Neuroscience Source Type: news

116 * hybrid multi-step approach to mega-aortic syndrome: the lupiae technique
Conclusions: These results show that the multi-step Lupiae hybrid technique is a safe and effective option for the treatment of patients with MAS, achieving the complete exclusion of thoraco-abdominal aneurysms with a low risk of paraplegia and endoleaks.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Esposito, G., Bichi, S., Cappabianca, G., Patrini, D., Pellegrino, P., Redaelli, M., Poloni, C., Peretti, E., Pennesi, M. Tags: Proximal aorta surgery: Extending to the descending aorta Source Type: research

Rapid and persistent impairments of the forelimb motor representations following cervical deafferentation in rats
Abstract Skilled motor control is regulated by the convergence of somatic sensory and motor signals in brain and spinal motor circuits. Cervical deafferentation is known to diminish forelimb somatic sensory representations rapidly and to impair forelimb movements. Our focus was to determine what effect deafferentation has on the motor representations in motor cortex, knowledge of which could provide new insights into the locus of impairment following somatic sensory loss, such as after spinal cord injury or stroke. We hypothesized that somatic sensory information is important for cortical motor map topography. To investiga...
Source: European Journal of Neuroscience - October 1, 2013 Category: Neuroscience Authors: Yu‐Qiu Jiang, Preston T. J. A. Williams, John H. Martin Tags: Research Report Source Type: research

Quantitative gait analysis of long-term locomotion deficits in classical unilateral striatal intracerebral hemorrhage rat model.
Abstract Gait analysis is a systematic collection of quantitative information on bodily movements during locomotion. Gait analysis has been employed clinically in stroke patients for their rehabilitation planning. In animal studies, gait analysis has been employed for the assessment their locomotive disturbances in ischemic stroke, spinal cord injury and Parkinson's disease. The aims of the work reported here were to identify the gait parameters, collected from the computer-generated CatWalk System, that change after unilateral intracerebral hemorrhage (ICH) in the acute stage and long term up to 56 days post-ICH....
Source: Behavioural Brain Research - October 11, 2013 Category: Neurology Authors: Liu Y, Ao LJ, Lu G, Leong E, Liu Q, Wang XH, Zhu XL, Sun TF, Fei Z, Jiu T, Hu X, Poon WS Tags: Behav Brain Res Source Type: research

Valproic Acid: A New Candidate of Therapeutic Application for the Acute Central Nervous System Injuries.
Abstract Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI), and spinal cord injury (SCI), are common causes of human disabilities and deaths, but the pathophysiology of these diseases is not fully elucidated and, thus, effective pharmacotherapies are still lacking. Valproic acid (VPA), an inhibitor of histone deacetylation, is mainly used to treat epilepsy and bipolar disorder with few complications. Recently, the neuroprotective effects of VPA have been demonstrated in several models of acute CNS injuries, such as stroke, TBI, and SCI. VPA protects the brain from injury p...
Source: Neurochemical Research - January 31, 2014 Category: Neuroscience Authors: Chen S, Wu H, Klebe D, Hong Y, Zhang J Tags: Neurochem Res Source Type: research

Comparing Periodic Limb Movements in Sleep in Subjects with and without Waking Paretic/Plegic Limbs (P5.286)
CONCLUSIONS: In this study, PLMS were more prevalent in subjects with waking paralysis/paresis compared to those without waking paralysis/paresis. We intend to meticulously analyze these PLMS and identify, qualify and quantify unique elements that more accurately approximate surviving neuronal connections between cortex/brainstem sleep and spinal movement centers, to improve prognostication and selection of paralyzed patients regarding aggressive physical/functional electrical stimulation therapies.Disclosure: Dr. Dyken has received research support for a study concerning Obstructive Sleep Apnea. Dr. Zimmerman has nothing ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dyken, M., Zimmerman, M., Im, K., Lin-Dyken, D., Glenn, C., Blumberg, M., Rodnitzky, R., Sokoloff, G. Tags: Sleep: Parasomnias and Measurement Technologies Source Type: research

Comparing Periodic Limb Movements in Sleep in Subjects with and without Waking Paretic/Plegic Limbs (I3-2.002)
CONCLUSIONS: In this study, PLMS were more prevalent in subjects with waking paralysis/paresis compared to those without waking paralysis/paresis. We intend to meticulously analyze these PLMS and identify, qualify and quantify unique elements that more accurately approximate surviving neuronal connections between cortex/brainstem sleep and spinal movement centers, to improve prognostication and selection of paralyzed patients regarding aggressive physical/functional electrical stimulation therapies.Disclosure: Dr. Dyken has received research support for a study concerning Obstructive Sleep Apnea. Dr. Zimmerman has nothing ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dyken, M., Zimmerman, M., Im, K., Lin-Dyken, D., Glenn, C., Blumberg, M., Rodnitzky, R., Sokoloff, G. Tags: Clocks, Sleep, Brain Health and Disorders: Impact on Mechanism, Expression, and Treatment Data Blitz Presentations Source Type: research

New rehabilitation models for neurologic inpatients in Brazil.
Conclusions: This is the first report on the effects from an inpatients rehabilitation model in Brazil. After a short intensive rehabilitation, there were motor and cognitive gains in all groups. Heterogeneity in functional gains suggests more individualized programs may be indicated. Controlled studies are required with larger samples to compare inpatient and outpatient programs. Implications for Rehabilitation The proposed brief model of rehabilitation for stroke, traumatic brain injury, spinal cord injury, and Guillain-Barre syndrome inpatients shows promising results in terms of functional improvement. Apparent improve...
Source: Disability and Rehabilitation - April 29, 2014 Category: Rehabilitation Authors: Jorge LL, Brito AM, Marchi FH, Hara AC, Battistella LR, Riberto M Tags: Disabil Rehabil Source Type: research

Anticoagulation for Noncardiac Indications in Neurologic Patients: Comparative Use of Non-Vitamin K Oral Anticoagulants, Low-Molecular-Weight Heparins, and Warfarin
Opinion statement Patients with neurologic disorders may develop a wide variety of thromboembolic events, both as a primary manifestation and as a consequence of their underlying neurologic condition. There are many available options for anticoagulation, ranging from warfarin to the parenteral subcutaneously administered anticoagulants to the non-vitamin K oral anticoagulants (NOACs). Warfarin is orally available, well-studied, and easily reversible in the setting of bleeding, but has a prolonged onset of action, measured in days, and equally slow offset; requires frequent monitoring for dose titration; and has m...
Source: Current Treatment Options in Neurology - July 19, 2014 Category: Neurology Source Type: research

Mesenchymal Stem Cells: Potential in Treatment of Neurodegenerative Diseases.
Abstract Mesenchymal Stem Cells or Marrow Stromal Cells (MSCs) have long been viewed as a potent tool for regenerative cell therapy. MSCs are easily accessible from both healthy donor and patient tissue and expandable in vitro on a therapeutic scale without posing significant ethical or procedural problems. MSC based therapies have proven to be effective in preclinical studies for graft versus host disease, stroke, myocardial infarction, pulmonary fibrosis, autoimmune disorders and many other conditions and are currently undergoing clinical trials at a number of centers all over the world. MSCs are also being exte...
Source: Current Stem Cell Research and Therapy - September 22, 2014 Category: Stem Cells Authors: Tanna T, Sachan V Tags: Curr Stem Cell Res Ther Source Type: research