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Disease Burden Among Patients With Multiple Overlapping Eosinophilic Diseases In The Real World Investigation Of Eosinophilic-Associated Disease Overlap (REVEAL) Study
The pathogenesis of multiple eosinophilic diseases (EDs) likely involves EID. Epidemiology and disease overlap among EDs are poorly understood. REVEAL is a retrospective claims study examining disease overlap among EDs, including allergic bronchopulmonary aspergillosis, atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria (CSU), asthma, COPD, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis, eosinophilic esophagitis (EoE), eosinophilic gastritis/gastroenteritis, and non-cystic fibrosis bronchiectasis.
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Justin Kwiatek, Anamaria Brailean, Danuta Kielar, Rohit Katial, Xia Wang, Xiao Xu, Sharon MacLachlan, Yong Jin Kim, Michael Stokes, Heide Stirnadel Farrant Source Type: research

Disturbance in bacterial community composition affects inflammatory ambiance and structural changes in non-Th2 asthma
We aimed to establish a relationship between lower airways bacterial patterns, inflammation and remodeling in 59 stable non-Th2 asthma patients vs. 19 COPD using CT, mass-spectrometry bacteriome analysis and cytokine ELISA of induced sputum at baseline and after 1 year.Results: In patients with BA, a higher diversity species composition of Streptococcus spp and Staphylococcus sp. was found as compared with COPD (p=0,03). Gram-neg. Klebsiella, E. coli, Ps.aeruginosa, H. influenzae, B. cepacia and T. paurometabola species were distinguished in the sputum samples, in association with the disease duration (0,5;p=0,03).Pro-infl...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Konishcheva, A., Gervazieva, V., Ospelnikova, T. Tags: Allergy and immunology Source Type: research

Microbiological features of the indicators of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) during remission
Conclusion: A more pronounced quantitative content and a more diverse microbial landscape leads to a more severe course of the disease asthma combined with COPD, especially of the bronchitis type.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Smirnova-Saprytskaya, M., Osipova, G., Ospelnikova, T., Danilina, G., Zykov, K. Tags: Allergy and immunology Source Type: research

A Novel Human Microbe-Disease Association Prediction Method Based on the Bidirectional Weighted Network
Conclusion Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consumin...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research