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The role of bacterial DNA containing CpG motifs in diseases.
Abstract Bacterial DNA containing unmethylated CpG motifs can activate immune cells to release proinflammatory cytokines. Here, the role of bacterial DNA containing CpG motifs in diseases with a focus on arthritis is discussed. Our studies demonstrate that the intraarticular injection of bacterial DNA and oligodeoxynucleotides containing CpG motifs (CpG ODN) induced arthritis. The induction of arthritis involves the role of macrophages over other cells such as neutrophils, NK cells, and lymphocytes. TNF-α and TNFRI play an important role in the development of arthritis. NF-κB also plays a critical regulatory rol...
Source: Journal of Leukocyte Biology - February 2, 2021 Category: Hematology Authors: Zhou J, Deng GM Tags: J Leukoc Biol Source Type: research

Bacterial acute non necrosing cellulitis (erysipelas) in adult.
Authors: Dezoteux F, Staumont-Sallé D Abstract Erysipelas is defined by a sudden onset (with fever) preceding the appearance of a painful, infiltrated, erythematous plaque, accompanied by regional lymphadenopathy. It is usually localized on the lower limbs, but it can occur on the face. It is due to β-hemolytic streptococcus A and more rarely to staphylococcus aureus. It is important to establish the diagnosis and eliminate the non-bacterial causes of inflammatory edema. The other diagnoses frequently found are contact eczema, acute arthritis, bursitis, inflammatory flare-up of chronic dermohypodermitis of venous...
Source: Revue de Medecine Interne - November 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Correctly adDRESS the cause of hemophagocytic lymphohistiocytosis.
We report on the case of a 3-year-old girl with no past medical history, who presented inaugural Pseudomonas aeruginosa maxillary osteitis, with secondary HLH. The rarity of this osteitis, the characteristics of the pathogen, and the onset of HLH oriented the diagnosis toward primary immunodeficiencies, malignancies, or systemic diseases. Steroids were initiated at 2mg/kg/day and were very effective in improving the systemic symptoms. Antibiotic therapy was continued unchanged. A few days after discontinuation of steroids, while the patient was still under antibiotics, she presented with erythroderma. Skin biopsy revealed...
Source: Archives de Pediatrie - January 31, 2017 Category: Pediatrics Authors: Penel-Page M, Ben Said B, Phan A, Hees L, Hartmann-Merlin C, Girard S, Gillet Y, Belot A Tags: Arch Pediatr Source Type: research

"It's A Scandal" -Daryl Hall on Doctors Denying Chronic Lyme
Growing up a musically-obsessed child in the 80's, Daryl Hall was one of my biggest inspirations. A masterful, inventive songwriter with an ocean of soul, he set me on the path to being an artist, to never waste a word, and to sing because I mean it. With six number ones and five additional top ten hits throughout the 70's and 80's Daryl Hall and John Oates are the number one duo in music history. Still at the top of his game at 69 years old, Daryl has won legions of new fans with his hit MTV Live show Live From Daryl's House. In February of 2015, at my very sickest from chronic Lyme and Bartonella, after it was missed b...
Source: Science - The Huffington Post - July 22, 2016 Category: Science Source Type: news

Question 2: Should steroids be used in the treatment of septic arthritis?
Scenario You are the paediatric registrar on duty when a 12-year-old boy is admitted to your ward with a strong suspicion of septic arthritis of the left knee. He plays soccer at competitive level; the boy and his parents are concerned about the long-term consequences for his playing. While you are waiting for the result of the white count of the synovial fluid to confirm the diagnosis and promptly start antibiotic therapy, you remember a recent discussion about the use of steroids in infectious disease, and so you decide to review the literature and analyse whether the use of steroids as an adjuvant therapy could improve ...
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Macchiaiolo, M., Buonuomo, P. S., Mennini, M., Villani, A., Bartuli, A. Tags: ADC Archimedes, Oncology, Football (soccer), Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Rheumatology, Trauma, Injury Source Type: research

Test for persistent Lyme infection using live ticks shown safe in clinical study
(NIH/National Institute of Allergy and Infectious Diseases) In a first-of-its-kind study for Lyme disease, researchers have used live, disease-free ticks to see if Lyme disease bacteria can be detected in people who continue to experience symptoms such as fatigue or arthritis after completing antibiotic therapy.
Source: EurekAlert! - Infectious and Emerging Diseases - February 12, 2014 Category: Infectious Diseases Source Type: news