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Specialty: Neurology
Condition: Carbon Monoxide Poisoning

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Total 264 results found since Jan 2013.

Nutraceutical induction and mimicry of heme oxygenase activity as a strategy for controlling excitotoxicity in brain trauma and ischemic stroke: focus on oxidative stress
Expert Rev Neurother. 2021 Feb;21(2):157-168. doi: 10.1080/14737175.2021.1861940. Epub 2020 Dec 28.ABSTRACTIntroduction: Ischemic stroke and traumatic brain injury are leading causes of acute mortality, and in the longer run, major causes of significant mental and physical impairment. Most of the brain neuronal cell death in the minutes and hours following an ischemic stroke or brain trauma is mediated by the process of excitotoxicity, in which sustained elevations of extracellular glutamate, reflecting a failure of ATP-dependent mechanism which sequester glutamate in neurons and astrocytes, drive excessive activation of N...
Source: Expert Review of Neurotherapeutics - December 8, 2020 Category: Neurology Authors: Mark F McCarty Aaron Lerner Source Type: research

Association Between Carbon Monoxide Intoxication and Incidence of Ischemic Stroke: A Retrospective Nested Case-Control Study in South Korea
Severe neurological sequelae occur in patients with carbon monoxide (CO) intoxication; however, whether the latter increases the long-term risk of developing ischemic stroke is unclear. We investigated the association between CO intoxication and ischemic stroke using data from the Korean National Health Information Database.
Source: Journal of Stroke and Cerebrovascular Diseases - December 3, 2020 Category: Neurology Authors: Kyeongmin Kwak, Min Kim, Won-Jun Choi, Young-Su Ju, Jong-Tae Park Source Type: research

Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption
At low levels, carbon monoxide (CO) has been shown to have beneficial effects on multiple organs and tissues through its potential anti-inflammatory, anti-apoptotic, and anti-proliferative properties. However,...
Source: Journal of Neuroinflammation - June 21, 2018 Category: Neurology Authors: Jianping Wang, Di Zhang, Xiaojie Fu, Lie Yu, Zhengfang Lu, Yufeng Gao, Xianliang Liu, Jiang Man, Sijia Li, Nan Li, Xuemei Chen, Michael Hong, Qingwu Yang and Jian Wang Tags: Research Source Type: research

Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice Basic Sciences
Conclusions—Clock gene expression regulates, in part, the severity of SAH and requires myeloid HO-1 activity to clear the erythrocyte burden and inhibit neuronal apoptosis. Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Nils Schallner, Judith-Lisa Lieberum, David Gallo, Robert H. LeBlanc III, Patrick M. Fuller, Khalid A. Hanafy, Leo E. Otterbein Tags: Inflammation, Translational Studies, Intracranial Hemorrhage Original Contributions Source Type: research

HO1 and Wnt expression is independently regulated in female mice brains following permanent ischemic brain injury.
Abstract A gender difference in stroke is observed throughout epidemiologic studies, pathophysiology, treatment and outcomes. We investigated the neuroprotective role of hemeoxygenase (HO) enzyme, which catabolizes free heme to bilirubin, carbon monoxide and biliverdin in the female brain after permanent ischemia. We have previously reported in male mice that genetic deletion of HO1 exacerbates the brain damage after permanent ischemia, and the mechanism of neuroprotection is dependent on the HO1/Wnt pathway; however, the role of HO1/Wnt mediated neuroprotection in the female brain is yet to be investigated. We su...
Source: Brain Research - February 16, 2017 Category: Neurology Authors: Tulsulkar J, Ward A, Shah Z Tags: Brain Res Source Type: research

Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study Clinical Sciences
Conclusions— In this large, community-based sample of individuals without clinical stroke/transient ischemic attack at baseline, higher exhaled CO was associated with a greater burden of subclinical cerebrovascular disease cross-sectionally and with increased risk of stroke/transient ischemic attack prospectively. Further investigation is necessary to explore the biological mechanisms linking elevated CO with stroke.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Nayor, M., Enserro, D. M., Beiser, A. S., Cheng, S., DeCarli, C., Vasan, R. S., Seshadri, S. Tags: Pathophysiology, Epidemiology, Primary Prevention, Magnetic Resonance Imaging (MRI), Ischemic Stroke Clinical Sciences Source Type: research

Akinetic Mutism And Parkinsonian Features Progressing To Coma Following A Hypoxic Event With Extended Lucid Interval: Manifestations Of Delayed Post-Hypoxic Leukoencephalopathy (P4.033)
CONCLUSIONS: Clinical anticipation and recognition of DPHL should lead to earlier diagnosis and higher-value care.Disclosure: Dr. Doerner Rinaldi has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Czeisler has nothing to disclose. Dr. Willey has nothing to disclose. Dr. John has nothing to disclose. Dr. Claassen has nothing to disclose. Dr. Mayer has received personal compensation for activities with Actelion, Baxter, Biogen Idec, Codman/Johnson & Johnson Company, CSL Behring, Cornerstone Therapeutics, CR Bard, Novartis, Orsan Technologies, Pfizer Inc, Sage Therapeutics, and Stryker. Dr. Mayer has receive...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Doerner Rinaldi, A. P., Miller, E., Czeisler, B., Willey, J., John, C., Claassen, J., Mayer, S., Agarwal, S. Tags: General Neurology III Source Type: research

Unusual Presentation of Acute Carbon Monoxide Poisoning (P6.024)
CONCLUSIONCO poisoning should be included in the differential diagnosis of patients found to have isolated bilateral thalamic involvement. MR imaging undertaken in acute setting aids in management and prognosis. Follow-up is required to assess for the development of Delayed Neuropsychiatric Syndrome, which can cause changes in personality, memory and gait.Disclosure: Dr. Bains has nothing to disclose. Dr. Reid has nothing to disclose. Dr. Huang has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bains, S., Reid, D., Huang, X. Tags: General Neurology VI Source Type: research

Combined Treatment of Methylprednisolone Pulse and Memantine Hydrochloride Prompts Recovery from Neurological Dysfunction and Cerebral Hypoperfusion in Carbon Monoxide Poisoning: A Case Report
A 49-year-old healthy man developed sudden unconsciousness under inadequate ventilation. Blood gas analysis showed carboxyhemoglobin of 7.3%. After normobaric oxygen therapy, he recovered completely 7 days later. At 3 weeks after carbon monoxide (CO) exposures, memory and gait disturbances appeared. Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. Brain fluid-attenuated inversion recovery imaging disclosed symmetric hypointense lesions in the thalamus and the globus pallidus, and hyperintense lesions in the cerebral w...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Konosuke Iwamoto, Ken Ikeda, Sunao Mizumura, Kazuhiro Tachiki, Masaru Yanagihashi, Yasuo Iwasaki Tags: Case Reports Source Type: research