Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice [Basic Sciences]

Conclusions—Clock gene expression regulates, in part, the severity of SAH and requires myeloid HO-1 activity to clear the erythrocyte burden and inhibit neuronal apoptosis. Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH.

Source: Stroke - August 28, 2017 Category: Neurology Authors: Nils Schallner, Judith-Lisa Lieberum, David Gallo, Robert H. LeBlanc III, Patrick M. Fuller, Khalid A. Hanafy, Leo E. Otterbein Tags: Inflammation, Translational Studies, Intracranial Hemorrhage Original Contributions Source Type: research