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The Role of Fractional Exhaled Nitric Oxide in Diagnosing Asthmatic Type 2 Chronic Rhinosinusitis With Nasal Polyps
CONCLUSION: FeNO is a useful marker for screening asthmatic T2-CRSwNP even prior to biopsy or asthma evaluation and may assist in selecting a proper treatment.PMID:37160729 | DOI:10.1177/19458924231173205
Source: American Journal of Rhinology and Allergy - May 10, 2023 Category: ENT & OMF Authors: Jin-A Park Hyunkyung Cha Seung Koo Yang Hyun Tae Ryu Do Won Kim Seung-No Hong Min Suk Yang Dae Woo Kim Source Type: research

Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease
Conclusion In this study, 57% of N-ERD patients tolerated higher doses of aspirin under dupilumab therapy.
Source: European Respiratory Journal - March 16, 2023 Category: Respiratory Medicine Authors: Schneider, S., Poglitsch, K., Morgenstern, C., Quint, T., Gangl, K., Sinz, C., Bartosik, T., Campion, N. J., Liu, D. T., Landegger, L. D., Tu, A., Stanek, V., Rocha-Hasler, M., Bangert, C., Eckl-Dorna, J. Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research

Aspirin Exacerbated Respiratory Disease and Nasal Polyp Phenotyping
Aspirin exacerbated respiratory disease (AERD) is known by the triad of chronic rhinosinusitis with nasal polyposis (CRSwNP), aspirin hypersensitivity, and asthma, but its etiology and physiopathogenesis are still unclear. This cross-sectional study was designed to investigate allergy and inflammatory cells (neutrophils vs. eosinophils) dominancy in nasal polyp tissue of patients with AERD compared to non-AERD patients. CRSwNP patients scheduled for endoscopic sinus surgery were recruited in this study. Nasal polyp tissue was analyzed for infiltrating cells, and Eosinophil dominant and neutrophil dominant polyps were deter...
Source: Iranian Journal of Pharmaceutical Research - December 4, 2021 Category: Drugs & Pharmacology Source Type: research

Olfaction in COPD
CONCLUSIONS: COPD is associated with olfactory dysfunction and the underlying mechanisms for this dysfunction should be elucidated.PMID:34647543 | DOI:10.4193/Rhin21.037
Source: Rhinology - October 14, 2021 Category: ENT & OMF Authors: W M Thorstensen M R Øie S B Dahlslett M Sue-Chu S K Steinsv åg A S Helvik Source Type: research

Effect of Benralizumab in Patients With Severe Eosinophilic Asthma and Chronic Rhinosinusitis With Nasal Polyps: A Case Series.
CONCLUSION: Usage of benralizumab in patients with SA and CRSwNP can lead to significantly improved asthma control, lung function, and sinonasal quality of life. Additionally, in this patient population, there was a subset of patients that showed a significant reduction in polyp burden. PMID: 33302694 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - December 10, 2020 Category: ENT & OMF Authors: Chitguppi C, Patel P, Gandler A, Murphy K, Khoury Md T, Monostra P, Bork S, Toskala E, Rabinowitz M, Rosen M, Nyquist G, Most J Tags: Am J Rhinol Allergy Source Type: research

Aspergillus sensitization and aspergillus-associated diseases in a sample of patients with severe asthma
Conclusions: The severe asthmatic patients examined had a high prevalence of Aspergillus sensitization and of Aspergillus-associated diseases as ABPA (26%) and CPA (26%). It has to be demonstrated the benefit of an early recognition and treatment of these diseases on the course of asthma.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Bucca, C., De Blasio, F., Dassetto, D., Ambrosanio, R., Rella, A., Riberi, L., Solidoro, P. Tags: Allergy and immunology Source Type: research

Diagnostic Accuracy of Urinary LTE4 Measurement to Predict Aspirin-Exacerbated Respiratory Disease in Patients with Asthma
Conclusions A set of typical clinical parameters has a superior accuracy in prediction of AERD diagnosis than the measurement of uLTE4 concentration alone. The addition of uLTE4 concentration to clinical parameters slightly enhances the prediction of AERD diagnosis, especially due to a high NPV.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2017 Category: Allergy & Immunology Source Type: research

Are atopy and eosinophilic bronchial inflammation associated with relapsing forms of chronic rhinosinusitis with nasal polyps?
Conclusion: In our pilot study, atopy, severe asthma, bronchial inflammation, NSAIDs hypersensitivity and high level of total IgE are possible useful prognostic factors for the proneness to relapse after FESS. The role of allergy in CRSwNP pathogenesis should consequently be given deeper consideration. Allergen specific immunotherapy, combined with anti-IgE therapy, may have an immunomodulatory effect preventing polyps relapse and need to be investigated.
Source: Clinical and Molecular Allergy - September 11, 2015 Category: Allergy & Immunology Authors: Mona-Rita YacoubMatteo TrimarchiGeorge CremonaSara Dal FarraGiuseppe RamirezValentina CantiEmanuel Della TorreMattia BaldiniPatrizia PignattiMario BussiMaria SabbadiniAngelo ManfrediGiselda Colombo Source Type: research

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