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A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Want to Lose Weight? Add This One Thing to Your Diet
What are the best ways to lose weight? originally appeared on Quora - the knowledge sharing network where compelling questions are answered by people with unique insights. Answer by Keck Medicine of USC, 500+ internationally renowned doctors at a leading academic medical center, on Quora: Learn the secret to losing weight - and improve your overall health at the same time. Fiber. It's not a sexy solution, but it's one that works wonders for maintaining a healthy weight. Beans, vegetables, fruit and grains all contain fiber, which helps keep your digestive tract clean, healthy and at peak function. But, did you know that...
Source: Healthy Living - The Huffington Post - December 28, 2016 Category: Consumer Health News Source Type: news

Catching Dick: Not Why We Care About Weight
Amy Schumer said in her humorous acceptance speech at the Glamour Women of the Year Awards: "I'm like 160 pounds right now, and I can catch a dick whenever I want, and that's the truth." The line, like many in her speech, is obviously very funny. But the humor is directed at a misperception that is not so funny. With our society's superficial focus on youth and appearance, we have emphasized all the wrong reasons for maintaining a healthy body weight, which has nothing to do with "catching dick." We are sold the idea that remaining slim is primarily important as a means of attracting the opposite sex, rather than as a pa...
Source: Science - The Huffington Post - June 4, 2015 Category: Science Source Type: news

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
We examined a possible protective effect of OX-A against LPS-induced ROS formation and microglia activation. To mimic in vitro the connection between gut and brain and to study the putative effect on the cortical microglia, we used a co-culture of Caco-2 cells and primary cortical microglia with Caco-2 cells placed at the apical side of a transwell and primary cortical microglia at the basolateral side. All treatments used to study the apical vs. basal connection were applied to the apical compartment. We used DHR (10 μM, 20 min), a cell-permeable fluorogenic probe useful for the detection of ROS formation, to dete...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Sex Difference of Radiation Response in Occupational and Accidental Exposure
Conclusion and Outlook This review summarizes the data from major human studies on the health risks of radiation exposure and shows that sex can potentially influence the prolonged response to radiation exposure (Figure 1 and Tables 1, 2). These data suggest that long-term radiosensitivity in females is higher than that in males who receive a comparable dose of radiation. Our analysis of the literature agrees with the conclusions of the recent report on the Biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences (NAS), United States (National Research Council, 2006). The B...
Source: Frontiers in Genetics - May 2, 2019 Category: Genetics & Stem Cells Source Type: research