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YAP1 Is Involved in Tumorigenic Properties of Prostate Cancer Cells.
In this study, YAP1 expression was upregulated in the whole cell lysates and cytoplasmic/nuclear extracts of AR negative (PC3) compared to AR positive (LNCaP) prostate cancer cell lines and primary prostate epithelial cells (PrePEC). pYAP1 expression elevated in LNCaP compared to PC3 and PrePEC in whole cell lysates and cytoplasmic extracts. The treatment of LNCaP and PC3 with YAP1-targeting siRNA oligonucleotides (YAP1 siRNA) significantly reduced their proliferation in vitro. Furthermore, treatment with YAP1 siRNA diminished the clonogenicity, anchorage-independent growth on soft agar, migration and invasion of PC3 cells...
Source: Pathology Oncology Research - March 10, 2019 Category: Pathology Authors: Collak FK, Demir U, Sagir F Tags: Pathol Oncol Res Source Type: research

Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Abstract To find the exact downstream effector of Pim-2 pathway in prostate cancer cells, and to determine the means by which it affects prostate cancer. XIAP, Pim-2 and p-eIF4B expressions were detected in PCA and BPH tissues. Then the Pim-2 and XIAP expressions were manipulated using transfection or RNAi in prostatic cells. Finally, Pim-2/eIF4B/XIAP levels were examined in PCA tissues with different clinicopathologic features. XIAP was significantly higher in PCA than in BPH tissues. When Pim-2 was transfected into noncancerous prostate epithelial cells RWPE-1, Pim-2, p-eIF4B and XIAP were all significantly incr...
Source: Pathology Oncology Research - November 9, 2017 Category: Pathology Authors: Ren K, Gou X, Xiao M, He W, Kang J Tags: Pathol Oncol Res Source Type: research

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer
Abstract Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition, and a catalytic reverse transcriptase (TERT). While expression of TERT has been considered the key rate limiting component for telomerase activity, increasing evidence suggests an important role for the regulation of TERC in telomere maintenance and perhaps other functions in human cancer. By using three orthogonal methods including RNAseq, RT‐qPCR, and an analytically validated chromogenic RNA in situ hybridization assay, we report consistent overexpression of TERC in prosta...
Source: The Journal of Pathology - September 9, 2017 Category: Pathology Authors: Javier A Baena ‐Del Valle, Qizhi Zheng, David M Esopi, Michael Rubenstein, Gretchen K Hubbard, Maria C Moncaliano, Andrew Hruszkewycz, Ajay Vaghasia, Srinivasan Yegnasubramanian, Sarah J Wheelan, Alan K Meeker, Christopher M Heaphy, Mindy K Graham, Ange Tags: Original Paper Source Type: research

Liver X receptor activation inhibits PC-3 prostate cancer cells via the beta-catenin pathway
Conclusions This study provided additional evidence that LXR activation inhibited PC-3 prostate cancer cells via suppressing beta-catenin pathway.
Source: Pathology Research and Practice - May 11, 2016 Category: Pathology Source Type: research

Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer
Conclusions Increased expression of CHKA, detectable by IHC, is seen in malignant lesions. This relatively simple cost-effective technique (IHC) could complement current diagnostic procedures for prostate cancer and, therefore, warrants further investigation.
Source: Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Challapalli, A., Trousil, S., Hazell, S., Kozlowski, K., Gudi, M., Aboagye, E. O., Mangar, S. Tags: Immunology (including allergy), Prostate cancer, Urological cancer Original article Source Type: research

Long Noncoding RNAs as Putative Biomarkers for Prostate Cancer Detection
Publication date: November 2014 Source:The Journal of Molecular Diagnostics, Volume 16, Issue 6 Author(s): Bongyong Lee , Joseph Mazar , Muhammad N. Aftab , Feng Qi , John Shelley , Jian-Liang Li , Subramaniam Govindarajan , Felipe Valerio , Inoel Rivera , Tadzia Thurn , Tien Anh Tran , Darian Kameh , Vipul Patel , Ranjan J. Perera Prostate cancer is one of the leading causes of mortality among US males. There is an urgent unmet need to develop sensitive and specific biomarkers for the early detection of prostate cancer to reduce overtreatment and accompanying morbidity. We identified a group of differentially expressed ...
Source: The Journal of Molecular Diagnostics - December 5, 2014 Category: Pathology Source Type: research

Oligophrenin-1 Is Associated with Cell Adhesion and Migration in Prostate Cancer
Conclusion: These results suggest that oligophrenin-1 is involved in tumor progression in PCa.Pathobiology 2014;81:190-198
Source: Pathobiology - November 7, 2014 Category: Pathology Source Type: research

Androgen deprivation therapy induces androgen receptor-dependent upregulation of Egr1 in prostate cancers.
This study also elucidated the potential mechanism underlying Id1 participation in the progression of prostate cancer. Understanding the key molecular events in the transition from ADPC to AIPC may provide new therapeutic intervention strategies for patients with AIPC. PMID: 25031707 [PubMed - in process]
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Xu B, Tang G, Xiao C, Wang L, Yang Q, Sun Y Tags: Int J Clin Exp Pathol Source Type: research

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