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Cancer: Prostate Cancer

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Total 18 results found since Jan 2013.

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates
We report that such coupling generates monomeric antibody–siRNA conjugates (ARCs) that retain antibody and siRNA activities. To broadly assess this technology, we generated a battery of THIOMABs against seven targets that use multiple internalization routes, enabling systematic manipulation of multiple parameters that impact delivery. We identify ARCs that induce targeted silencing in vitro and extend tests to target prostate carcinoma cells following systemic administration in mouse models. However, optimal silencing was restricted to specific conditions and only observed using a subset of ARCs. Trafficking studies ...
Source: Nucleic Acids Research - January 23, 2015 Category: Research Authors: Cuellar, T. L., Barnes, D., Nelson, C., Tanguay, J., Yu, S.-F., Wen, X., Scales, S. J., Gesch, J., Davis, D., van Brabant Smith, A., Leake, D., Vandlen, R., Siebel, C. W. Tags: RNA Source Type: research

Farnesoid X receptor ligand CDCA suppresses human prostate cancer cells growth by inhibiting lipid metabolism via targeting sterol response element binding protein 1.
CONCLUSION: Our study indicates that activation of FXR inhibits lipid metabolism via SREBP1 pathway and further suppresses prostate tumor growth in vitro. PMID: 27904713 [PubMed - in process]
Source: American Journal of Translational Research - December 3, 2016 Category: Research Tags: Am J Transl Res Source Type: research

ZFP91: A Noncanonical NF- κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer.
ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer. Biomed Res Int. 2016;2016:6963582 Authors: Paschke L, Jopek K, Szyszka M, Tyczewska M, Ziolkowska A, Rucinski M, Malendowicz LK Abstract Novel molecular targets are being searched to aid in prostate cancer diagnosis and therapy. Recently, ZFP91 zinc finger protein has been found to be upregulated in prostate cancer cell lines. It is a potentially important oncogenic protein; however only limited data regarding its biological function and expression patterns are available. To date, ZF...
Source: Biomed Res - December 17, 2016 Category: Research Authors: Paschke L, Jopek K, Szyszka M, Tyczewska M, Ziolkowska A, Rucinski M, Malendowicz LK Tags: Biomed Res Int Source Type: research

miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1.
Abstract miR-221 is regarded as an oncogene in many malignancies, and miR-221-mediated resistance towards TRAIL was one of the first oncogenic roles shown for this small noncoding RNA. In contrast, miR-221 is downregulated in prostate cancer (PCa), thereby implying a tumour suppressive function. By using proliferation and apoptosis assays, we show a novel feature of miR-221 in PCa cells: instead of inducing TRAIL resistance, miR-221 sensitized cells towards TRAIL-induced proliferation inhibition and apoptosis induction. Partially responsible for this effect was the interferon-mediated gene signature, which among o...
Source: Biomed Res - December 14, 2019 Category: Research Authors: Krebs M, Behrmann C, Kalogirou C, Sokolakis I, Kneitz S, Kruithof-de Julio M, Zoni E, Rech A, Schilling B, Kübler H, Spahn M, Kneitz B Tags: Biomed Res Int Source Type: research

The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
The androgen receptor (AR) is a key molecule involved in prostate cancer (PC) development and progression. Post-translational modification of the AR by co-regulator proteins can modulate its transcriptional activity. To identify which demethylases might be involved in AR regulation, an siRNA screen was performed to reveal that the demethylase, KDM4B, may be an important co-regulator protein. KDM4B enzymatic activity is required to enhance AR transcriptional activity; however, independently of this activity, KDM4B can enhance AR protein stability via inhibition of AR ubiquitination. Importantly, knockdown of KDM4B in multip...
Source: Nucleic Acids Research - April 22, 2013 Category: Research Authors: Coffey, K., Rogerson, L., Ryan-Munden, C., Alkharaif, D., Stockley, J., Heer, R., Sahadevan, K., O'Neill, D., Jones, D., Darby, S., Staller, P., Mantilla, A., Gaughan, L., Robson, C. N. Tags: Gene Regulation, Chromatin and Epigenetics Source Type: research

A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation
MicroRNAs (miRNAs) have been implicated in DNA repair pathways through transcriptional responses to DNA damaging agents or through predicted miRNA regulation of DNA repair genes. We hypothesized that additional DNA damage regulating miRNAs could be identified by screening a library of 810 miRNA mimetics for the ability to alter cellular sensitivity to ionizing radiation (IR). A prostate cancer Metridia luciferase cell model was applied to examine the effects of individual miRNAs on IR sensitivity. A large percentage of miRNA mimetics were found to increase cellular sensitivity to IR, while a smaller percentage were protect...
Source: Nucleic Acids Research - May 2, 2015 Category: Research Authors: Hatano, K., Kumar, B., Zhang, Y., Coulter, J. B., Hedayati, M., Mears, B., Ni, X., Kudrolli, T. A., Chowdhury, W. H., Rodriguez, R., DeWeese, T. L., Lupold, S. E. Tags: Genome integrity, repair and replication Source Type: research

Improving the Bioavailability and Anticancer Effect of the PCA-1/ALKBH3 Inhibitor HUHS015 Using Sodium Salt
Prostate cancer antigen (PCA)-1/AlkB homologue 3 (ALKBH3) has been identified as a clinically significant factor and siRNA of PCA-1 inhibits DU145 proliferation both in vitro and in vivo. HUHS015 (1), a previous reported PCA-1 small-molecule inhibitor, was also effective without any obvious side-effects or toxicity. The potency of HUHS015, however, is not satisfying. We thought the reason is poor solubility of HUHS015 because insoluble material remained at the injection site after subcutaneous administration. To improve this inhibitor's solubility, we prepared various salts of HUHS015 and examined their solubility, which r...
Source: In Vivo - January 19, 2015 Category: Research Authors: MABUCHI, M., SHIMIZU, T., UEDA, M., SASAKAWA, Y., NAKAO, S., UEDA, Y., KAWAMURA, A., TSUJIKAWA, K., TANAKA, A. Tags: Experimental Studies Source Type: research

Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and VEGFs and COX-2 in prostate cancer
Limited information is available on the pathological significance of human antigen R (HuR) in prostate cancer (PCa). The main aim of this study was to clarify the relationship between HuR expression and malignant aggressiveness, outcome, and expression of cancer-related molecules in PCa. In vitro proliferation, colony formation, and migration assays were performed on LNCaP and PC-3 cells. HuR expression was knocked down (KD) using siRNA. The relationships between HuR expression and the expression of vascular endothelial growth factors (VEGFs), cyclooxygenase (COX)-2, and hemeoxygenase (HO)-1 were investigated in PCa cell l...
Source: Translational Research - April 14, 2016 Category: Research Authors: Kensuke Mitsunari, Yasuyoshi Miyata, Akihiro Asai, Tomohiro Matsuo, Yohei Shida, Tomoaki Hakariya, Hideki Sakai Source Type: research

Androgen receptor (AR) promotes male bladder cancer cell proliferation and migration via regulating CD24 and VEGF.
This study was aimed to investigate the roles of AR in bladder cell proliferation and metastasis and to explore its potential mechanism. Expressions of AR in two kinds of bladder tumor cells (T24 and UM-UC-3) were analyzed using the CRISPR Activation Plasmid transfection or siRNA-mediated gene. The effects of AR on tumor cell proliferation and migration were also analyzed. Moreover, the effects of CD24 and influence of AR on cell proliferation and metastasis-related protein were also analyzed. The results showed that AR was significantly down-regulated in T24 cells but was significantly overexpressed in UM-UC-3 cells. The ...
Source: American Journal of Translational Research - May 10, 2016 Category: Research Tags: Am J Transl Res Source Type: research

miR-143 Induces the Apoptosis of Prostate Cancer LNCap Cells by Suppressing Bcl-2 Expression.
CONCLUSIONS Transfection of miR-143 induces the apoptosis of prostate cancer LNCap cells by down-regulating Bcl-2 expression, suggesting that Bcl-2 might be a potential therapeutic target for prostate cancer. PMID: 28109198 [PubMed - in process]
Source: Medical Science Monitor - January 23, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Histone Deacetylase (HDAC) Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), Induces Apoptosis in Prostate Cancer Cell Lines via the Akt/FOXO3a Signaling Pathway.
CONCLUSIONS Treatment with SAHA promoted apoptosis via the Akt/FOXO3a signaling pathway in prostate cancer cells in vitro. PMID: 29211704 [PubMed - in process]
Source: Medical Science Monitor - December 8, 2017 Category: Research Tags: Med Sci Monit Source Type: research

URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion.
Abstract Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lin...
Source: Biomed Res - June 30, 2018 Category: Research Authors: Pan B, Ye Y, Liu H, Zhen J, Zhou H, Li Y, Qu L, Wu Y, Zeng C, Zhong W Tags: Biomed Res Int Source Type: research

Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is Associated with the Progression of Human Prostate Cancer and is Downregulated by MicroRNA-5193.
CONCLUSIONS TRIM11 was upregulated in prostate cancer tissue and was associated with reduced prognosis. TRIM11 expression increased cell proliferation in vitro and was downregulated by miR-5193. PMID: 30608062 [PubMed - in process]
Source: Medical Science Monitor - January 6, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Nimotuzumab inhibits epithelial –mesenchymal transition in prostate cancer by targeting the Akt/YB‐1/AR axis
In this study, we presented our novel findings that by targeting the Akt/YB‐1/AR axis, nimotuzumab significantly inhibited EMT of PC cells. Considering that EMT is a critical mechanism contributing to the metastatic spread of cancer cells, nimotuz umab may become a promising therapy for alleviating the malignant progression of PC. © 2019 IUBMB Life, 1–14, 2019
Source: IUBMB Life - March 24, 2019 Category: Research Authors: Sheng Hu, Yi ‐Xing Duan, Qiang Zhou, Yong Wang, Qiang Lu Tags: Research Communication Source Type: research