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Total 241 results found since Jan 2013.
Chronic eosinophilic pneumonia after radiation therapy for squamous cell lung cancer
Publication date: Available online 5 August 2017 Source:Respiratory Medicine Case Reports Author(s): Hiromasa Nakayasu, Toshihiro Shirai, Yuko Tanaka, Mika Saigusa Reports of chronic eosinophilic pneumonia (CEP) after radiation therapy are limited to breast cancer. We herein describe a case of CEP after radiation therapy for lung cancer. The patient was a 65-year-old man who had asymptomatic peripheral blood eosinophilia but no history of asthma or allergy. One month after completion of radiation therapy, chest CT scan revealed infiltrates inside the irradiated area, leading to the diagnosis of radiation pneumonitis. His ...
Source: Respiratory Medicine Case Reports - August 6, 2017 Category: Respiratory Medicine Source Type: research
UK Backs Opdivo for Lung Cancer After Bristol-Myers Cuts Price UK Backs Opdivo for Lung Cancer After Bristol-Myers Cuts Price
Bristol-Myers Squibb ' s immunotherapy drug Opdivo has been recommended for some patients with lung cancer by Britain ' s healthcare cost watchdog NICE after the drugmaker agreed a discounted price.Reuters Health Information
Source: Medscape Allergy Headlines - September 21, 2017 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California
Conclusions:
Residential proximity to road traffic volumes and traffic density were associated with increased all-cause mortality in patients undergoing treatment for active tuberculosis even after adjusting for multiple demographic, socioeconomic, and clinical factors, suggesting that TB patients are susceptible to the adverse health effects of traffic-related air pollution. https://doi.org/10.1289/EHP1699
Received: 31 January 2017
Revised: 18 August 2017
Accepted: 23 August 2017
Published: 29 September 2017
Address correspondence to R.J. Blount, Divisions of Pulmonary and Critical Care Medicine and Pediatric Pulmon...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Residential Air Pollution and Associations with Wheeze and Shortness of Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European Cohorts
Conclusion:
Exposure to PM and NO2 air pollution was associated with the prevalence of wheeze and shortness of breath in this large study, with stronger associations between PM2.5 and both outcomes among lower- versus higher-income participants. https://doi.org/10.1289/EHP1353
Received: 13 November 2016
Revised: 10 August 2017
Accepted: 14 August 2017
Published: 29 September 2017
Address correspondence to D. Doiron, Research Institute of the McGill University Health Centre, 2155 rue Guy, office 458, Montreal, Canada, H3H 2R9. Telephone: 1-514-934-1934 (ex. 71688). Email: ddoiron@maelstrom-research.org
Supplemental Ma...
Source: EHP Research - September 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Conclusions:
These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937
Received: 21 March 2017
Revis...
Source: EHP Research - October 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
Merck Keytruda Sales Soar, but European Application Pulled Merck Keytruda Sales Soar, but European Application Pulled
Merck& Co on Friday said quarterly sales of its Keytruda cancer immunotherapy exceeded $1 billion for the first time, but it withdrew an application for European use of the drug in lung cancer, raising questions about future sales.Reuters Health Information
Source: Medscape Allergy Headlines - October 30, 2017 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T cell responses
A particular characteristic of non-small cell lung cancer (NSCLC) is the composition of the tumor microenvironment with a very high proportion of fibroblastic stromal cells (FSC).
Source: Journal of Allergy and Clinical Immunology - February 3, 2018 Category: Allergy & Immunology Authors: Hung-Wei Cheng, Lucas Onder, Jovana Cupovic, Maximilian Boesch, Mario Novkovic, Natalia Pikor, Ignazio Tarantino, Regulo Rodriguez, Tino Schneider, Wolfram Jochum, Martin Brutsche, Burkhard Ludewig Source Type: research
Immune Checkpoint Blockade Therapy
Immune checkpoints are accessory molecules that either promote or inhibit T cell activation. Two inhibitory molecules, cytotoxic T cell antigen 4 (CTLA-4) and programmed death 1 (PD-1), got high attention, as inhibition of CTLA-4 or PD-1 signaling provides the first immune therapy that significantly improves the survival of patients with metastatic solid cancers. Inhibition of CTLA-4 or PD-1 was first studied in and approved for patients with metastatic melanoma. Blocking immune checkpoints is also efficient in non-small-cell lung cancer, renal cell cancers, hypermutated gastro-intestinal cancers and others.
Source: Journal of Allergy and Clinical Immunology - March 26, 2018 Category: Allergy & Immunology Authors: Thomas Wieder, Thomas Eigentler, Ellen Brenner, Dipl Biol, Martin R öcken Source Type: research
Changes in gene expression in lungs of mice exposed to traffic-related air pollution
Publication date: Available online 3 April 2018 Source:Molecular and Cellular Probes Author(s): Jie Yang, Yi Chen, Zhi Yu, Hui Ding, Zhongfu Ma Long-term exposure to traffic-related pollutants can lead to a variety of respiratory diseases, including inflammation, asthma, and lung cancer; however, the underlying biological mechanisms are not fully understood. We focused on the effects of exposure to different air pollutants on the expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer. In order to understand the cellular responses induced by exposure to different t...
Source: Molecular and Cellular Probes - April 14, 2018 Category: Molecular Biology Source Type: research
Immune checkpoint blockade therapy
Immune checkpoints are accessory molecules that either promote or inhibit T-cell activation. Two inhibitory molecules, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), got high attention, as inhibition of CTLA-4 or PD-1 signaling provides the first immune therapy that significantly improves the survival of patients with metastatic solid cancers. Inhibition of CTLA-4 or PD-1 was first studied in and approved for patients with metastatic melanoma. Blocking immune checkpoints is also efficient in non –small-cell lung cancer, renal cell cancers, hypermutated gastrointestinal cancers, and others.
Source: Journal of Allergy and Clinical Immunology - March 26, 2018 Category: Allergy & Immunology Authors: Thomas Wieder, Thomas Eigentler, Ellen Brenner, Martin R öcken Tags: Current perspectives Source Type: research
CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses
A particular characteristic of non –small cell lung cancer is the composition of the tumor microenvironment with a very high proportion of fibroblastic stromal cells (FSCs).
Source: Journal of Allergy and Clinical Immunology - February 3, 2018 Category: Allergy & Immunology Authors: Hung-Wei Cheng, Lucas Onder, Jovana Cupovic, Maximilian Boesch, Mario Novkovic, Natalia Pikor, Ignazio Tarantino, Regulo Rodriguez, Tino Schneider, Wolfram Jochum, Martin Brutsche, Burkhard Ludewig Source Type: research
Changes in gene expression in lungs of mice exposed to traffic-related air pollution
Publication date: June 2018Source: Molecular and Cellular Probes, Volume 39Author(s): Jie Yang, Yi Chen, Zhi Yu, Hui Ding, Zhongfu MaAbstractLong-term exposure to traffic-related pollutants can lead to a variety of respiratory diseases, including inflammation, asthma, and lung cancer; however, the underlying biological mechanisms are not fully understood. We focused on the effects of exposure to different air pollutants on the expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer. In order to understand the cellular responses induced by exposure to different traff...
Source: Molecular and Cellular Probes - July 5, 2018 Category: Molecular Biology Source Type: research
AstraZeneca ' s Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial AstraZeneca ' s Pivotal Lung Cancer Trial Fails Main Goal in Late Stage Trial
AstraZeneca said on Friday its immunotherapy drug Imfinzi did not meet the main goal of improving survival rates for patients with the most advanced form of lung cancer, putting pressure on its shares.Reuters Health Information
Source: Medscape Allergy Headlines - November 20, 2018 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news
Interleukin-17A a potential therapeutic target in chronic lung diseases.
CONCLUSION: IL-17A is a major regulator of inflammatory responses. In all the mentioned diseases, IL-17A plays a prime role in inducing the diseases, whereas the lack of this pro-inflammatory cytokine reduces the severity of respective respiratory diseases. Thereby, this review suggests IL-17A as an instrumental target in the chronic respiratory diseases.
PMID: 30652654 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 15, 2019 Category: Endocrinology Authors: Shaikh SB, Prabhu A, Bhandary YP Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
