Filtered By:
Cancer: Glioma
Therapy: Gene Therapy
This page shows you your search results in order of date.
Order by Relevance | Date
Total 71 results found since Jan 2013.
Recent and anticipated novel drug approvals for 2023 and 2024
CONCLUSION: Several new novel drugs in the pipeline are intended for use in treating cancers, autoimmune conditions, and rare diseases such as sickle cell disease.PMID:37688502 | DOI:10.1093/ajhp/zxad220
Source: American Journal of Health-System Pharmacy : AJHP - September 9, 2023 Category: Drugs & Pharmacology Authors: Matthew H Rim Farah Barada Andrew M Levitsky Source Type: research
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial
This study aimed to evaluate the safety and activity of two adenoviral vectors expressing HSV1-TK (Ad-hCMV-TK) and Flt3L (Ad-hCMV-Flt3L) in patients with high-grade glioma.METHODS: In this dose-finding, first-in-human trial, treatment-naive adults aged 18-75 years with newly identified high-grade glioma that was evaluated per immunotherapy response assessment in neuro-oncology criteria, and a Karnofsky Performance Status score of 70 or more, underwent maximal safe resection followed by injections of adenoviral vectors expressing HSV1-TK and Flt3L into the tumour bed. The study was conducted at the University of Michigan Me...
Source: Ann Oncol - September 1, 2023 Category: Cancer & Oncology Authors: Yoshie Umemura Daniel Orringer Larry Junck Maria L Varela Molly E J West Syed M Faisal Andrea Comba Jason Heth Oren Sagher Denise Leung Aaron Mammoser Shawn Hervey-Jumper Daniel Zamler Viveka N Yadav Patrick Dunn Wajd Al-Holou Todd Hollon Michelle M Kim D Source Type: research
Brain-Targeted Nano-Architectures for Efficient Drug Delivery and Sensitization in Glioblastoma
CONCLUSION: The present review focuses on the mechanisms involved in the resistance of glioma cells to chemotherapeutic agents, nano-pharmacokinetics, diverse types of nano-architectures used for potent delivery of the medicine and sensitization in GBM, their recent clinical advances, potential challenges, and future perspective.PMID:37403389 | DOI:10.2174/1381612829666230703113141
Source: Current Pharmaceutical Design - July 5, 2023 Category: Drugs & Pharmacology Authors: R J A Vibhavari Vanishree Rao Gautam Kumar Suman Manandhar Sri Pragnya Cheruku Priya Bisht Mallikarjuna Rao Chamallmudi Krishnadas Nandakumar Lalit Kumar Nitesh Kumar Source Type: research
Combination of B7H6-siRNA and temozolomide synergistically reduces stemness and migration properties of glioblastoma cancer cells
This study aimed to understand the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer. U87 cells were treated with B7H6-siRNA and temozolomide, separately and in combination. Cell viability, stemness, cell migration, and apoptosis were measured. The results of this work presented the synergistic effect of B7H6-siRNA and temozolomide in inhibiting the cancerous features of the U87 cell line. Down-regulating B7H6-siRNA expression inhibited the cell viability of U87 glioblastoma cancer cells and increased their sensitivity to temozolomide. In addition, a not...
Source: Experimental Cell Research - May 29, 2023 Category: Cytology Authors: Nadia Allahyarzadeh Khiabani Mohammad Amin Doustvandi Fateme Mohammadnejad Elnaz Salmani Hassan Kohal Neda Boushehri Mahdi Jafarlou Behzad Baradaran Source Type: research
Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1
In this study, the role of lung cancer associated transcript 1 (lncRNA LUCAT 1) in glioma occurrence and development, as well as its possible regulatory mechanism, was explored. We utilized the gene chip technology in the preliminary experiment, and based on the experiment results, selected LUCAT1（NONHSAT102745）, which was significantly upregulated in glioma, and ATP-binding cassette Subfamily B member l (ABCB1), which was significantly down-regulated in co-expression analysis, for study. Next, the expression of LUCAT1 and ABCB1 in cells and tissues was immediately evaluated. Subsequently, the cells were transfected wi...
Source: Cell Research - October 21, 2022 Category: Cytology Authors: Xia Wu Lvmeng Song Xiangrong Chen Yalan Zhang Shun Li Xiaoping Tang Source Type: research
Potent bystander effect and tumor tropism in suicide gene therapy using stem cells from human exfoliated deciduous teeth
Cancer Gene Ther. 2022 Sep 8. doi: 10.1038/s41417-022-00527-5. Online ahead of print.ABSTRACTHerpes simplex virus thymidine kinase (HSVTK)/ganciclovir (GCV) suicide gene therapy has a long history of treating malignant gliomas. Recently, stem cells from human exfoliated deciduous teeth (SHED), which are collected from deciduous teeth and have excellent harvestability, ethical aspects, and self-renewal, have been attracting attention mainly in the field of gene therapy. In the present study, we assessed SHED as a novel cellular vehicle for suicide gene therapy in malignant gliomas, as we have previously demonstrated with va...
Source: Herpes - September 8, 2022 Category: Infectious Diseases Authors: Makoto Horikawa Shinichiro Koizumi Tomoya Oishi Taisuke Yamamoto Masashi Ikeno Masahiko Ito Tomohiro Yamasaki Shinji Amano Tetsuro Sameshima Yasuyuki Mitani Yoshihiro Otani Yuanqing Yan Tetsuro Suzuki Hiroki Namba Kazuhiko Kurozumi Source Type: research
Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases
Mol Ther Methods Clin Dev. 2022 Jul 6;26:253-265. doi: 10.1016/j.omtm.2022.07.001. eCollection 2022 Sep 8.ABSTRACTLung cancer is one of the most common cancers, and the number of patients with intracranial metastases is increasing. Previously, we developed an enzyme prodrug suicide gene therapy based on the herpes simplex virus thymidine kinase (HSV-TK)/ganciclovir (GCV) system using various mesenchymal stem cells to induce apoptosis in malignant gliomas through bystander killing effects. Here, we describe stem cells from human exfoliated deciduous teeth (SHED) as gene vehicles of the TK/GCV system against a brain metastas...
Source: Clinical Lung Cancer - July 27, 2022 Category: Cancer & Oncology Authors: Tomoya Oishi Masahiko Ito Shinichiro Koizumi Makoto Horikawa Taisuke Yamamoto Satoru Yamagishi Tomohiro Yamasaki Tetsuro Sameshima Tetsuro Suzuki Haruhiko Sugimura Hiroki Namba Kazuhiko Kurozumi Source Type: research
