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Specialty: Biochemistry
Cancer: Hepatocellular Carcinoma
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Total 1206 results found since Jan 2013.
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119595. doi: 10.1016/j.bbamcr.2023.119595. Online ahead of print.ABSTRACTThe nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important mechanism for the positive regulation of NF-κB activity. According to our previous data, p65 can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes p65 nuclear import and HCC progression. However, the effect of SUMO1-related p65 SUMOylation on NF-κB transcriptional activity and the relations...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Can Jiang Chunyang Zhang Min Dai Fuyan Wang Sa Xu Dan Han Yanyan Wang Yajie Cao Yanyan Liang Ziyu Zhang Lina Yan Yujun Shen Kewu He Yuxian Shen Jun Liu Source Type: research
Synthesis and its characterisation of selenium/silver/chitosan and cellular toxicity against liver carcinoma cells studies
Nat Prod Res. 2023 Sep 14:1-9. doi: 10.1080/14786419.2023.2256023. Online ahead of print.ABSTRACTLiver cancer is one of the most common lethal malignancy in the world. To treat liver cancer, new cure options are crucial. The use of natural substances along nanosciences may provide healing with lower toxicity and a smaller amount of side properties. In this research, The three-component selenium-silver-chitosan nanocomposite (Se-Ag-CS NCs) were synthesised with the help of ultrasound in a stepwise manner. The as-synthesised Se-Ag-CS NCs were characterised accordingly by applying powder X-Ray diffraction (PXRD), Fourier tran...
Source: Natural Product Research - September 14, 2023 Category: Biochemistry Authors: Fateme Momen Eslamieh-Ei Negar Sharifimoghaddammood Samira Amin Poustchi Tousi Samira Basharkhah Javad Mottaghipisheh Ali Es-Haghi Mohammad Ehsan Taghavizadeh Yazdi Marcello Iriti Source Type: research
PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway
Biochem Biophys Res Commun. 2023 Sep 9;680:15-24. doi: 10.1016/j.bbrc.2023.09.007. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the world's third most fatal cancer. Because metabolic rewiring is a hallmark of HCC, studies into the causes of aberrant glycolysis could provide insight into novel HCC therapeutic strategies. Pyrroline-5-carboxylate reductase 2 (PYCR2), a key enzyme of proline synthesis, has previously been found to play vital roles in various malignancies regarding amino acid metabolism and oxidative stress response. Our study investigated the mechanistic function of PYCR2 in HCC. We used Gen...
Source: Biochemical and Biophysical Research communications - September 14, 2023 Category: Biochemistry Authors: Shaoyan Wang Wenyan Yi Zhenyu Xu Minyu Shi Source Type: research
Involvement of proliferation of atypical hepatocytes and CDT 1 in the liver cancer of rats administered the diethylnitrosamine
J Clin Biochem Nutr. 2023 Sep;73(2):138-144. doi: 10.3164/jcbn.13-16. Epub 2023 Sep 1.ABSTRACTWe have reported that extent of proliferation of atypical hepatocytes (POAH) in non-cancerous liver in hepatocellular carcinoma and chromatin licensing and DNA replication factor 1 (CDT1) are associated with postoperative recurrence. Here, we investigated whether extent of POAH and expression of CDT1 in liver are also associated with chemically induced liver cancer in rats. Male Fisher strain rats were orally administered diethylnitrosamine (DEN) in their drinking water and sacrificed at 6, 8, 12, or 14 weeks after start of DEN ad...
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Masahiro Ogawa Ryota Masuzaki Tatsuo Kanda Hiroshi Matsumura Hitomi Nakamura Motomi Yamazaki Toshikatu Shibata Hirofumi Kogure Mitsuhiko Moriyama Source Type: research
Apoptin and apoptotic protease-activating factor 1 plasmid-assisted multi-functional nanoparticles in hepatocellular carcinoma therapy
Int J Biol Macromol. 2023 Sep 11:126870. doi: 10.1016/j.ijbiomac.2023.126870. Online ahead of print.ABSTRACTCancer drugs usually have side effects in chemotherapy. Apoptin, a protein recognized by its good therapeutical effect on tumors and innocuous to body, is employed to treat hepatocellular carcinoma (HCC). As our previous data shown, the efficiency of apoptin protein might be limited by the protein of apaf-1. Therefore, we designed the multi-functional nanoparticles (MFNPs) encapsulating apoptin and apaf-1 plasmids by layer-by layer assembly. The NPs could release drugs into tumor site specifically and had good compat...
Source: International Journal of Biological Macromolecules - September 13, 2023 Category: Biochemistry Authors: Jiawei Zhang Tiantian Guo Xinyi Liu Shuyue Guo Yao Wang Baokuan Zhu Meiling Zhang Xiujun Gao Jingyu Wang Source Type: research
Glycan node profiling of soluble and membrane glycoproteins in whole cell lysates
Anal Biochem. 2023 Sep 10:115317. doi: 10.1016/j.ab.2023.115317. Online ahead of print.ABSTRACTGlycan node analysis (GNA) is a molecularly bottom-up glycomics technique based on the relative quantification of glycan linkage-specific monosaccharide units ("glycan nodes"). It was originally applied to blood plasma/serum, where it detected and predicted progression, reoccurrence, and survival in different types of cancer. Here, we have adapted this technology to previously inaccessible membrane glycoproteins from cultured cells. The approach is facilitated by methanol/chloroform precipitation of cell lysates and a "liquid pha...
Source: Analytical Biochemistry - September 12, 2023 Category: Biochemistry Authors: Jes ús S Aguilar Díaz de León Jorvani Cruz Villarreal Erandi P Kapuruge Chad R Borges Source Type: research
Siparuna guianensis essential oil antitumoral activity on Ehrlich model and its effect on oxidative stress
Chem Biodivers. 2023 Sep 10:e202301120. doi: 10.1002/cbdv.202301120. Online ahead of print.ABSTRACTThis work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) received a daily dose of S. guianensis oil orally (100 mg/kg) for 9 days. The main constituents of essential oil were curzerenone (16.4±1.5%), drimenol (13.7±0.2%), and spathulenol (12.4±0.8%). S. guianensis oil showed antioxidant activity, inhibiting 11.1% of DPPH radicals (95.7...
Source: Chemistry and Biodiversity - September 10, 2023 Category: Biochemistry Authors: Lucas Gabriel Viana Barbosa Ellen Nayara Silva de Jesus Lucas Botelho Jer ônimo Jamile Silva da Costa Renata Cunha Silva William N Setzer Joyce Kelly R da Silva Jofre Jacob da Silva Freitas Pablo Luis Figueiredo Source Type: research
Recent advances in natural polysaccharides against hepatocellular carcinoma: A review
Int J Biol Macromol. 2023 Sep 7:126766. doi: 10.1016/j.ijbiomac.2023.126766. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is a malignant tumor of the digestive system that poses a serious threat to human life and health. Chemotherapeutic drugs commonly used in the clinic have limited efficacy and heavy adverse effects. Therefore, it is imperative to find effective and safe alternatives, and natural polysaccharides (NPs) fit the bill. This paper summarizes in detail the anti-HCC activity of NPs in vitro, animal and clinical trials. Furthermore, the addition of NPs can reduce the deleterious effects of chemot...
Source: International Journal of Biological Macromolecules - September 9, 2023 Category: Biochemistry Authors: Dazhen Wang Zhengfeng Zhang Lu Zhao Liu Yang ChangJie Lou Source Type: research
