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Specialty: Drugs & Pharmacology
Cancer: Hepatocellular Carcinoma

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Total 82 results found since Jan 2013.

microRNA15b induced SMCC7721 apoptosis via down-regulation of XIAP.
CONCLUSIONS: microRNA15b induced apoptosis of SMCC7721 cells via down-regulation of XIAP. PMID: 28239814 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 1, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Fucoidan-induced ID-1 suppression inhibits the in vitro and in vivo invasion of hepatocellular carcinoma cells.
In conclusion, NDRG-1/CAP43-dependent down-regulation of ID-1 suppressed HCC invasion both in vitro and in vivo, which was modulated by fucoidan treatment. Moreover, the compensatory down-regulation of ID-1 against hypoxia-induced HCC invasion was observed. ID-1 is a novel therapeutic target for the treatment of metastatic HCC. PMID: 27459117 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 22, 2016 Category: Drugs & Pharmacology Authors: Cho Y, Cho EJ, Lee JH, Yu SJ, Kim YJ, Kim CY, Yoon JH Tags: Biomed Pharmacother Source Type: research

Inhibition of human hepatocellular carcinoma tumor angiogenesis by siRNA silencing of VEGF via hepatic artery perfusion.
CONCLUSIONS: Our data demonstrated that VEGF silencing could suppress cells proliferation, promote cells apoptosis and reduce HCC angiogenesis through inactivation of VEGF/PI3K/AKT signaling pathway. PMID: 26744866 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - January 15, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Pharmacokinetics and Biodistribution of Recently-Developed siRNA Nanomedicines.
Abstract Small interfering RNA (siRNA) is a promising drug candidate, expected to have broad therapeutic potentials toward various diseases including viral infections and cancer. With recent advances in bioconjugate chemistry and carrier technology, several siRNA-based drugs have advanced to clinical trials. However, most cases address local applications or diseases in the filtering organs, reflecting remaining challenges in systemic delivery of siRNA. The difficulty in siRNA delivery is in large part due to poor circulation stability and unfavorable pharmacokinetics and biodistribution profiles of siRNA. This rev...
Source: Advanced Drug Delivery Reviews - December 10, 2015 Category: Drugs & Pharmacology Authors: Park J, Park J, Pei Y, Xu J, Yeo Y Tags: Adv Drug Deliv Rev Source Type: research

Licorice Root Components in Dietary Supplements are Selective Estrogen Receptor Modulators with a Spectrum of Estrogenic and Anti-Estrogenic Activities
Publication date: Available online 26 November 2015 Source:Steroids Author(s): Nittaya Boonmuen, Ping Gong, Zulfiqar Ali, Amar G. Chittiboyina, Ikhlas Khan, Daniel R. Doerge, William G. Helferich, Kathryn E. Carlson, Teresa Martin, Pawinee Piyachaturawat, John A. Katzenellenbogen, Benita S. Katzenellenbogen Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extra...
Source: Steroids - November 27, 2015 Category: Drugs & Pharmacology Source Type: research

RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.
Abstract RNA interference has emerged as an innovative technology for gene silencing that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs (siRNAs). Its therapeutic application has important advantages over small-molecule drugs since offers the possibility of targeting virtually all genes and allows selective silencing of one or several genes. So far, a relative small proportion of cellular proteins can bind and respond to chemical drugs. Based on that, RNA interference-mediated gene silencing is widely considered as a crucial breakthrough in molecular biology with a...
Source: Current Pharmaceutical Design - October 23, 2015 Category: Drugs & Pharmacology Authors: Gonzalez-Rodriguez A, Valverde AM Tags: Curr Pharm Des Source Type: research

GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis
CONCLUSIONS AND IMPLICATIONSGPR55 is involved in the migratory behavior of colon carcinoma cells and may serve as a pharmacological target for the prevention of metastasis. This article is protected by copyright. All rights reserved.
Source: British Journal of Pharmacology - October 5, 2015 Category: Drugs & Pharmacology Authors: J Kargl, L Andersen, C Hasenöhrl, D Feuersinger, A Stančić, A Fauland, C Magnes, A El‐Heliebi, S Lax, S Uranitsch, J Haybaeck, A Heinemann, R Schicho Tags: RESEARCH PAPER Source Type: research

Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma.
CONCLUSION: A direct relationship exists between the miRNA processing machinery AGO2 and HCC angiogenesis that is mediated by the AGO2/PTEN/VEGF signaling pathway. The results suggest the high value of Ago2 knockdown in anti-angiogenesis therapy for HCC. PMID: 25937637 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 4, 2015 Category: Drugs & Pharmacology Authors: Ye ZL, Huang Y, Li LF, Zhu HL, Gao HX, Liu H, Lv SQ, Xu ZH, Zheng LN, Liu T, Zhang JL, Jin HJ, Qian QJ Tags: Acta Pharmacol Sin Source Type: research

Development of a simple, biocompatible and cost-effective Inulin- Diethylenetriamine based siRNA delivery system.
In conclusion, we developed a novel inulin-based siRNA delivery system able to efficiently release siRNA in JHH6 with negligible cytotoxicity thus opening the way for further testing in more complex in vivo models. PMID: 25845631 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - April 3, 2015 Category: Drugs & Pharmacology Authors: Sardo C, Farra R, Licciardi M, Dapas B, Scialabba C, Giammona G, Grassi M, Grassi G, Cavallaro G Tags: Eur J Pharm Sci Source Type: research

Momordica Charantia lectin exhibits antitumor activity towards hepatocellular carcinoma
Conclusion Our data show that the natural compound MCL manifests antitumor activities towards HCC and therefore suggest MCL as a promising chemotherapeutic agent.
Source: Investigational New Drugs - January 15, 2015 Category: Drugs & Pharmacology Source Type: research

Metabolism of gamma hydroxybutyrate in human hepatoma HepG2 cells by the Aldo-Keto Reductase AKR1A1.
In this study, the extent of AKR1A1 in GHB metabolism has been determined in HepG2 cells using RNA-interference technology. The gene encoding AKR1A1 was targeted by siRNA. Results demonstrate a successful knock-down of the AKR1A1 gene with 92% reduction in total mRNA and 93% reduction in protein expression. Demolishing AKR1A1 expression in HepG2 cells leads to significant 82% decrease in NADP-dependent GHB-dehydrogenase activity at high concentration (10mM) of GHB. Moreover, when exposing the cells to 50μM of GHB for 24hours, and measuring intracellular and extracellular GHB levels by GC/MS, a significant two-fold increas...
Source: Biochemical Pharmacology - September 22, 2014 Category: Drugs & Pharmacology Authors: Alzeer S, Ellis EM Tags: Biochem Pharmacol Source Type: research

MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.
Conclusion:MiR-506 suppresses the proliferation of hepatoma cells by targeting YAP mRNA. PMID: 25087998 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - August 4, 2014 Category: Drugs & Pharmacology Authors: Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH Tags: Acta Pharmacol Sin Source Type: research

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
Abstract Since it has been known that shikonin derived from a medicinal plant possesses anti-cancer activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, could be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX), an oncoprotein from hepatitis B virus. When ASK was added to Hep3B cells stably expressing HBX, it induced apoptosis in a dose-dependent manner. ASK induced upregulation and export of Nur77 to the cytoplasm and activation of JNK. Likewise, suppression of Nur77 and JNK inactivation protected the cells from ASK-induced apoptosis, indicating that N...
Source: European Journal of Pharmacology - April 24, 2014 Category: Drugs & Pharmacology Authors: Moon J, Koh SS, Malilas W, Cho IR, Kaewpiboon C, Kaowinn S, Lee K, Jhun BH, Choi YW, Chung YH Tags: Eur J Pharmacol Source Type: research

5'-triphosphate-siRNA activates RIG-I-dependent type I interferon production and enhances inhibition of hepatitis B virus replication in HepG2.2.15 cells.
In conclusion, our findings suggest that 3p-siRNA could act as a powerful bifunctional antiviral molecule with potential for developing a promising therapeutic against chronic HBV infection. PMID: 24099962 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - October 4, 2013 Category: Drugs & Pharmacology Authors: Chen X, Qian Y, Yan F, Tu J, Yang X, Xing Y, Chen Z Tags: Eur J Pharmacol Source Type: research

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
Conclusions and ImplicationsEmodin mediated its effects predominantly through inhibition of the STAT3 signalling cascade and thus has a particular potential for the treatment of cancers expressing constitutively activated STAT3.
Source: British Journal of Pharmacology - October 1, 2013 Category: Drugs & Pharmacology Authors: Aruljothi Subramaniam, Muthu K Shanmugam, Tina H Ong, Feng Li, Ekambaram Perumal, Luxi Chen, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Kam M Hui, Gautam Sethi Tags: RESEARCH PAPER Source Type: research