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Condition: Gastritis
Cancer: Adenocarcinoma
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Total 178 results found since Jan 2013.
Crystal structure of the apurinic/apyrimidinic endonuclease XthA (HP1526 protein) from Helicobacter pylori
In this study, the structure of the recombinant HP1526 protein from H. pylori (HpXthA) has been determined at a high resolution of 1.84 Å. From the structural analysis the HpXthA was found to belong to the Xth-like AP endonuclease family carrying the common fold of a central bilayer β-sheet flanked by α-helices with a divalent metal ion bound. A Mn2+ ion and a 1,3-butanediol were unusually found and modeled around the active site. Structural and sequence comparisons among the AP endonucleases show well-conserved residues for metal and DNA binding and for catalysis. Interestingly, the presence of a small polar residue Se...
Source: Biochemical and Biophysical Research communications - April 28, 2023 Category: Biochemistry Authors: Thom Dinh Oanh Dao Asaithambi Killivalavan Duong Ngo Kon Ho Lee Source Type: research
Genome and population dynamics during chronic infection with Helicobacter pylori
Curr Opin Immunol. 2023 Mar 21;82:102304. doi: 10.1016/j.coi.2023.102304. Online ahead of print.ABSTRACTHelicobacter pylori is responsible for one of the most prevalent bacterial infections worldwide. Chronic infection typically leads to chronic active gastritis. Clinical sequelae, including peptic ulcers, mucosa-associated lymphoid tissue lymphoma or, most importantly, gastric adenocarcinoma develop in 10-15% of cases. H. pylori is characterized by extensive inter-strain diversity which is the result of a high mutation rate, recombination, and a large repertoire of restriction-modification systems. This diversity is thoug...
Source: Current Opinion in Immunology - March 23, 2023 Category: Allergy & Immunology Authors: Sebastian Suerbaum Florent Ailloud Source Type: research
The role of magnification endoscopy in the early diagnosis of gastric signet ring cell carcinoma
We present the case of a 67-year-old woman referred to our outpatient clinic presenting dyspepsia. Gastroscopy was performed, showing antral gastritis. Random biopsies were taken, being positive for poorly differentiated Lauren's diffuse gastric adenocarcinoma. Narrow-band imaging gastroscopy was performed, combining random and targeted biopsies, with negative results. The study was completed with echoendoscopy and thoraco-abdominal-pelvic CT scan, showing no relevant pathological findings. Control endoscopic was performed after 12 months, showing no macroscopic lesions. Random biopsies were repeated, being positive for di...
Source: Cancer Control - January 31, 2023 Category: Cancer & Oncology Authors: C ésar Gómez Díez Pablo Miles Wolfe Garc ía Laura Garc ía Alles Álvaro Terán Lantarón Source Type: research
Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
In conclusion, it seems that most risk factors function more as a set of switches that initiated the GAC carcinogenesis. H. Pylori eradication and control of other risk factors should be conducted before IM to decrease the incidence of GAC.PMID:36713177 | PMC:PMC9878447 | DOI:10.3389/fmicb.2022.1024155
Source: Cancer Control - January 30, 2023 Category: Cancer & Oncology Authors: Zhaofeng Chen Ya Zheng Ping Fan Min Li Wei Liu Hao Yuan Xin Liu Zhiyi Zhang Zhengqi Wu Yuping Wang Rui Ji Qinghong Guo Yuwei Ye Jinhua Zhang Xiaohua Li Feng An Linzhi Lu Youpeng Li Xiang Wang Jun Zhang Quanlin Guan Qiang Li Min Liu Qian Ren Xiaobin Hu Hon Source Type: research
Berberine for Gastric Cancer Prevention and Treatment: Multi-step Actions on the Correa's Cascade Underlie its Therapeutic Effects
In conclusion, the therapeutic strategy underlying BBR's multi-step action in the trilogy of Correa's cascade may include "prevention of gastric mucosal inflammation (Phase 1); reversal of gastric precancerous lesions (Phase 2), and rescue of GC (Phase 3)." The NF-κB, PI3K/Akt, and MAPK signaling pathways may be the key signaling transduction pathways underlying the treatment of gastric carcinogenesis using BBR. The advantage of BBR over conventional drugs is its multifaceted and long-term effects. This review is expected to provide preclinical evidence for using BBR to prevent gastric carcinogenesis and treat gastric can...
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Qingsong Liu Jianyuan Tang Shuanglan Chen Shuangyuan Hu Caifei Shen Juyi Xiang Nianzhi Chen Jundong Wang Xiao Ma Yi Zhang Jinhao Zeng Source Type: research
Claudin-18
CONCLUSIONS.—: Claudin-18 staining was similar in intestinal metaplasia, dysplasia, and adenocarcinoma. Claudin-18 was negative in most cases of intestinal metaplasia in autoimmune gastritis, indicating that intestinal metaplasia in this setting may differ from other forms. Claudin-18 was sensitive and specific for gastric origin in neuroendocrine tumors.PMID:35976638 | DOI:10.5858/arpa.2021-0428-OA
Source: Archives of Pathology and Laboratory Medicine - August 17, 2022 Category: Laboratory Medicine Authors: Mary T Wong Aatur D Singhi Brent K Larson Carissa A T Huynh Bonnie L Balzer Miguel Burch Deepti Dhall Alexandra Gangi Jun Gong Maha Guindi Andrew E Hendifar Stacey A Kim Mariza de Peralta-Venturina Kevin M Waters Source Type: research
Clinical and pathological profile of gastric neuroendocrine tumors
CONCLUSION: Biological behavior of G-NET varies with different types and grades of tumor. Typing and grading of G-NET should be done whenever possible to predict the aggressiveness of the tumor.PMID:35900481 | DOI:10.4103/ijpm.ijpm_824_21
Source: Indian Journal of Pathology and Microbiology - July 28, 2022 Category: Pathology Authors: Aravind Sekar Kim Vaiphei Source Type: research
