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Total 25 results found since Jan 2013.

Detection of Ferroptosis in Models of Brain Diseases
Methods Mol Biol. 2023;2712:233-251. doi: 10.1007/978-1-0716-3433-2_21.ABSTRACTFerroptosis is a regulated form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. In the past decade, ferroptosis has been reported to be involved in the pathological role in the central nervous system degenerative diseases (e.g., Alzheimer's disease, Huntington's disease, and Parkinson's disease), stroke, traumatic brain injury, and brain tumor. However, how to reliably detect and classify ferroptosis from other cell death in pathological conditions remains a great challenge, especially in primary brain cells and brain ti...
Source: Mol Biol Cell - August 14, 2023 Category: Molecular Biology Authors: Danmin Shen Fei Yang Qian Li Source Type: research

Galangin as an inflammatory response modulator: An updated overview and therapeutic potential
Chem Biol Interact. 2023 Apr 10:110482. doi: 10.1016/j.cbi.2023.110482. Online ahead of print.ABSTRACTNumerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used to show potent anti-inflammatory activity. The flavonols enhanced the synthesis of the anti-inflammatory cytokines transforming growth factor and interleukin-10 (IL-10) and reduced the synthesis of the prostaglandins IL-6, tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2),...
Source: Chemico-Biological Interactions - April 12, 2023 Category: Molecular Biology Authors: Riya Thapa Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Ahsas Goyal Waleed Hassan Almalki Sami I Alzarea Imran Kazmi Vikash Jakhmola Sachin Kumar Singh Kamal Dua Ritu Gilhotra Gaurav Gupta Source Type: research

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
AbstractThe molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role ofApold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression ofApold1 is restricted to the vasculature and thatApold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. UsingApold1−/− mice, we find thatApold1 is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the ...
Source: Angiogenesis - March 18, 2023 Category: Molecular Biology Source Type: research

Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF- κB signaling pathway
CONCLUSIONS: These findings indicate that ICT plays roles in inhibiting the inflammatory response and achieving neuroprotection by regulating GPER-ERK-NF-κB signaling and then inhibiting microglial activation and M1 polarization while promoting M2 polarization, which provides a new therapeutic for against cerebral ischemic stroke.PMID:36447154 | DOI:10.1186/s10020-022-00573-7
Source: Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Zining Yu Guangjun Su Limei Zhang Gaigai Liu Yonggang Zhou Shicai Fang Qian Zhang Tianyun Wang Cheng Huang Zhihua Huang Liangdong Li Source Type: research

60 Years of Achievements by KSNM in Neuroimaging Research
Nucl Med Mol Imaging. 2022 Feb;56(1):3-16. doi: 10.1007/s13139-021-00727-1. Epub 2022 Jan 15.ABSTRACTNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60 years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfu...
Source: Molecular Medicine - February 21, 2022 Category: Molecular Biology Authors: Jae Seung Kim Hye Joo Son Minyoung Oh Dong Yun Lee Hae Won Kim Jungsu Oh Source Type: research

Mental depression: Relation to different disease status, newer treatments and its association with COVID-19 pandemic (Review)
Mol Med Rep. 2021 Dec;24(6):839. doi: 10.3892/mmr.2021.12479. Epub 2021 Oct 11.ABSTRACTThe present study aimed to review major depression, including its types, epidemiology, association with different diseases status and treatments, as well as its correlation with the current COVID-19 pandemic. Mental depression is a common disorder that affects most individuals at one time or another. During depression, there are changes in mood and behavior, accompanied by feelings of defeat, hopelessness, or even suicidal thoughts. Depression has a direct or indirect relation with a number of other diseases including Alzheimer's disease...
Source: Molecular Medicine Reports - October 11, 2021 Category: Molecular Biology Authors: Mohamed S Abdel-Bakky Elham Amin Tarek M Faris Ahmed A H Abdellatif Source Type: research

Isolation and Purification of Self-Renewable Human Neural Stem Cells from iPSCs for Cell Therapy in Experimental Model of Ischemic Stroke
Methods Mol Biol. 2022;2389:165-175. doi: 10.1007/978-1-0716-1783-0_14.ABSTRACTNeural stem cell therapy has been galvanized by the discovery of pluripotent stem cells. The possibility to generate specialized central nervous system-specific differentiated cells using human somatic cells engineered to become induced pluripotent stem cells (iPSCs) was a game changer. This technology has broad applications in the field of regenerative medicine, in vitro disease modeling, targeted drug discovery, and precision medicine. Currently, iPSCs are one of the most promising cell sources amenable for commercialization and off-the-shelf ...
Source: Mol Biol Cell - September 24, 2021 Category: Molecular Biology Authors: Marcel M Daadi Source Type: research

PAC proton-activated chloride channel contributes to acid-induced cell death in primary rat cortical neurons.
Authors: Osei-Owusu J, Yang J, Del Carmen Vitery M, Tian M, Qiu Z Abstract Severe local acidosis causes tissue damage and pain, and is associated with many diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation. However, the molecular mechanisms of the cellular response to extracellular acidic environment are not fully understood. We recently identified a novel and evolutionarily conserved membrane protein, PAC (also known as PACC1 or TMEM206), encoding the proton-activated chloride (Cl-) channel, whose activity is widely observed in human cell lines. We demonstrated that genetic del...
Source: Channels - February 26, 2020 Category: Molecular Biology Tags: Channels (Austin) Source Type: research