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Condition: Ischemic Stroke
Cancer: Brain Cancers

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Total 832 results found since Jan 2013.

Late-onset vascular complications of radiotherapy for primary brain tumors: a case-control and cross-sectional analysis
CONCLUSIONS: Stroke prevalence is increased in long-surviving PBT patients treated with cranial RT.IMPLICATIONS FOR CANCER SURVIVORS: CV events are frequent in long survivors of PBT treated with cerebral RT. We propose a check list to guide management of late CV complications in adults treated with RT for PBT.PMID:37142871 | DOI:10.1007/s11764-023-01350-z
Source: Cancer Control - May 4, 2023 Category: Cancer & Oncology Authors: Mar ía-José Ibáñez-Juliá Alberto Picca Delphine Leclercq Giulia Berzero Julian Jacob Lo ïc Feuvret Charlotte Rosso Cristina Birzu Agusti Alentorn Marc Sanson Camille Tafani Flavie Bompaire Luis Bataller Kh ê Hoang-Xuan Jean-Yves Delattre Dimitri Ps Source Type: research

Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors
Neurotox Res. 2023 May 2. doi: 10.1007/s12640-023-00644-5. Online ahead of print.ABSTRACTStroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of deaths worldwide each year. Since currently available therapies are insufficient, there is an urgent need for novel neuroprotective strategies to address the effects of cerebrovascular accidents. One such recent approach is based on the neuroprotective properties of estrogen receptors (ERs). However, activation of ERs by estrogens may contribute to the development of endometriosis or hormone-dependent cancers. Therefore, in this study, we util...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Bernadeta A Pietrzak Agnieszka Wnuk Karolina Przepi órska Andrzej Łach Ma łgorzata Kajta Source Type: research

Promoted Generation of T Helper 1-Like Regulatory T Cells After Transient Middle Cerebral Artery Occlusion in Type-2 Diabetic Mice
CONCLUSION: The generation of Th1-like Tregs was promoted in the brains of type 2 diabetic mice after stroke. Our study reveals significant Treg plasticity in diabetic stroke.Abbreviations: Foxp3: forkhead box P3; IFN-γ: interferon-γ; IL-10: interleukin-10; IL-12: interleukin-12; MCAO: middle cerebral artery occlusion; PBS: phosphate-buffered saline; STAT1: Signal transducer and activator of transcription 1; STAT5: Signal transducer and activator of transcription 1; T-bet: T-box expressed in T cells; TGF-β: transforming growth factor-β; Th1: T helper 1; TNF-α: tumor necrosis factor-α; Tregs: regulatory T cells. Foxp3...
Source: Immunological Investigations - April 19, 2023 Category: Allergy & Immunology Authors: Lei Jian Yanqi Hu Mingjie Gao Long Shu Source Type: research

Rev-erb α agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway
Conclusion: Taken together, Rev-erbα activation by SR9009 protects against ischemic stroke damage, at least, partly through Nrf2 pathway.PMID:37063298 | PMC:PMC10102520 | DOI:10.3389/fphar.2023.1102567
Source: Pharmacological Reviews - April 17, 2023 Category: Drugs & Pharmacology Authors: Mingyue Sheng Xun Chen Yan Yu Qi Wu Junping Kou Gangling Chen Source Type: research

Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Rev-erb α agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway
Conclusion: Taken together, Rev-erbα activation by SR9009 protects against ischemic stroke damage, at least, partly through Nrf2 pathway.
Source: Frontiers in Pharmacology - March 31, 2023 Category: Drugs & Pharmacology Source Type: research