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Cancer: Squamous Cell Carcinoma

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Total 783 results found since Jan 2013.

Safety and Efficacy of TGF- β1/COX-2 Silencing Therapeutic in Adults With Cutaneous Squamous Cell Carcinoma In Situ
J Drugs Dermatol. 2022 May 1;21(5):472-477. doi: 10.36849/JDD.6384.ABSTRACTThis single-center, open label, dose escalation cohort study evaluated the safety and efficacy of various doses of intralesional injections of TGF-β1/COX-2 combined with histidine-lysine polypeptide (siRNA/HKP) nanoparticle silencing therapeutic in patients with cutaneous in situ squamous cell carcinoma. Twenty-five patients (mean age: 67, SD: 10 years; 52% men) with cutaneous in situ squamous cell carcinoma participated. TGF-β1/COX-2 siRNA/HKP nanoparticle therapeutic was injected weekly for up to 6 weeks based on the following do...
Source: Journal of Drugs in Dermatology - May 9, 2022 Category: Dermatology Authors: Mark Nestor Brian Berman Patrick Lu Michael Molyneaux Source Type: research

CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF- β/Smad/c-Myc pathway
ConclusionCCT6A facilitates ESCC malignant activities by activating the TGF- β/Smad/c-Myc pathway, which sheds light on the identification of a possible therapeutic target in the management of ESCC.
Source: Irish Journal of Medical Science - April 5, 2023 Category: General Medicine Source Type: research

Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines.
This study was conducted to determine the mechanism by which β-catenin regulates the viability of HNSCC. AMC-HN-3, -HN-8, UM-SCC-38, and -SCC-47 cells, which were established from human head and neck cancer specimens, underwent cell death following β-catenin silencing. β-Catenin silencing significantly induced G1 arrest and increased the expression of Bax and active caspase-3, which demonstrates the sequential activation of apoptotic cascades following treatment of HNSCC with targeted siRNA. Intriguingly, β-catenin silencing also induced autophagy. Here, we confirm that the number of autophagic vacuoles and the express...
Source: Cellular Signalling - December 29, 2012 Category: Cytology Authors: Chang HW, Lee YS, Nam HY, Han M, Kim HJ, Moon SY, Hyesungjeon, Park JJ, Carey TE, Chang SE, Kim SW, Kim SY Tags: Cell Signal Source Type: research

Regulation of HIF‐1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells
Proprotein convertases (PC), a family of serine proteases, process cancer‐related substrates such as growth factors, growth factor receptors, cell adhesion molecules, metalloproteinases, etc. HIF‐1α is a major transcription factor involved in tumorigenesis by sensing intratumoral hypoxia. Furin (PCSK3) is one of the numerous target genes regulated by HIF‐1α transactivation and its distribution into endosomal compartments and onto the cell surface can be triggered by hypoxia via HIF‐1α. siRNAs to knockdown PCs were transfected into cells alone or in combination with different drug treatments. Protein and RNA expr...
Source: Molecular Carcinogenesis - January 1, 2014 Category: Molecular Biology Authors: Jian Fu, Jirong Zhang, Yulan Gong, Courtney Lyons Testa, Andres J. Klein‐Szanto Tags: Research Article Source Type: research

miR-21 modulates chemosensitivity of tongue squamous cell carcinoma cells to cisplatin by targeting PDCD4.
In this study, we investigated the effects and molecular mechanisms of miR-21 in chemosensitivity of tongue squamous cell carcinoma cells (TSCC) to cisplatin. miR-21 expression was detected in tongue cancer tissue using RT-PCR and PDCD4 protein expression was measured using immunohistochemistry. miR-21 and(or) PDCD4 depleted cell lines were generated using miR-21 inhibitor and(or) siRNA. The viabilities of treated cells were analyzed using MTT assay. RT-PCR was used to detect miR-21 expression and immunoblotting was used to detect protein levels. Cell cycle and apoptosis were analyzed using propidium iodide (PI) staining a...
Source: Molecular and Cellular Biochemistry - March 11, 2014 Category: Biochemistry Authors: Ren W, Wang X, Gao L, Li S, Yan X, Zhang J, Huang C, Zhang Y, Zhi K Tags: Mol Cell Biochem Source Type: research

Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma
This study showed that the mRNA and protein levels of PTHLH in 9 OSCC cell lines were much higher than that in normal epithelial cells (P
Source: Journal of Experimental and Clinical Cancer Research - December 18, 2014 Category: Cancer & Oncology Authors: Zhongjing LvXiangbing WuWei CaoZongZe ShenLizhen WangFuRong XieJianJun ZhangTong JiMing YanWanTao Chen Source Type: research

Podoplanin is involved in the prognosis of head and neck squamous cell carcinoma through interaction with VEGF-C.
Authors: Kim HY, Rha KS, Shim GA, Kim JH, Kim JM, Huang SM, Koo BS Abstract We investigated the clinical significance of podoplanin expression in relation to clinicopathological variables in head and neck squamous cell carcinoma (HNSCC), to determine its effectiveness as a marker for high-risk HNSCC patients. Upregulation of podoplanin in HNSCC tissues was examined using immunohistochemistry and clinicopathological analyses. Wound healing and invasion assays were performed using HNSCC cells that were transfected with podoplanin siRNA, podoplanin vector and cotransfection with both the podoplanin vector and VEGF-C s...
Source: Oncology Reports - June 20, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research