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Differences in Thymus and Activation-Regulated Chemokine and Squamous Cell Carcinoma Antigen 2 Levels in Food Protein-Induced Enterocolitis Syndrome and Atopic Dermatitis
Conclusion: Assessing the relative TARC/SCCA2 ratio may help predict whether elevated TARC levels measured after vomiting are caused by FPIES or AD.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - May 10, 2022 Category: Allergy & Immunology Source Type: research

A Serum Level of Squamous Cell Carcinoma Antigen as a Real-Time Biomarker of Atopic Dermatitis
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Source: Pediatric, Allergy, Immunology, and Pulmonology - August 19, 2021 Category: Respiratory Medicine Authors: Masaki Shimomura Yuka Okura Yutaka Takahashi Ichiro Kobayashi Source Type: research

Occupational Skin Disease in Physicians: A Review of the Literature
ConclusionsThe most frequently reported OSD in physicians is contact dermatitis from allergens in disinfectants and rubber gloves. There is also a risk of cutaneous reactions to latex. The incidence of skin cancer was higher in physicians than in the general population, and the reason for this remains unexplained and potentially biased. There are no reports of transmission of patient HPV to surgeons during wart ablation, possibly because of proper use of protective equipment.
Source: Annals of Occupational Hygiene - October 3, 2020 Category: Occupational Health Source Type: research

Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions
Conclusions and Future Perspectives It is now evident that NK/ILC family plays a pivotal role in the immune defenses. Recent studies in murine and human settings demonstrated that the expression of several inhibitory checkpoints, that may be detrimental in the tumor context, is not restricted to T lymphocytes, revealing an important, yet poorly appreciated, contribution of their expression on innate immune cells. Thus, in the recent years different immunotherapy approaches, based on the blockade of inhibitory NK cell receptors, have been developed in order to unleash NK cell cytotoxicity. This is particularly important in...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Human TH9 differentiation is dependent on signal transducer and activator of transcription (STAT) 3 to restrain STAT1-mediated inhibition
Patients with loss-of-function (LOF) signal transducer and activator of transcription 3 (STAT3) mutations have dermatitis, enhanced IgE production despite a relative lack of immediate hypersensitivity, recurrent infection, and an increased rate of lymphoma in addition to a number of skeletal and connective tissue abnormalities. Patients with STAT1 gain-of-function (GOF) mutations also have susceptibility to candidiasis and sinopulmonary infection, as well as autoimmunity and squamous cell carcinoma, in addition to even more broad phenotypes.
Source: Journal of Allergy and Clinical Immunology - July 17, 2018 Category: Allergy & Immunology Authors: Yuan Zhang, Andrea M. Siegel, Guangping Sun, Tom Dimaggio, Alexandra F. Freeman, Joshua D. Milner Source Type: research

Serum squamous cell carcinoma antigen-2 is a highly sensitive biomarker for atopic dermatitis in children
Squamous cell carcinoma antigen (SCCA) was reported to be elevated in various inflammatory skin diseases including atopic dermatitis (AD). Since Th2 cytokines stimulate SCCA production in the skin tissue, possible utility of serum SCCA as a biomarker for AD has been suggested, but merely by single-center, small-scale studies.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Toshiaki Kawano, Mizuho Nagao, Takao Fujisawa, Hiroshi Odajima, Shinichiro Inagaki, Yukihiro Ohya, Yoshinori Azuma, Noriko Nomura, Kenji Izuhara Source Type: research

Atopic Dermatitis Associated With Higher Risk of Skin Cancer
Individuals with a history of atopic dermatitis have a higher risk of squamous cell carcinoma development
Source: The Doctors Lounge - Oncology - December 29, 2017 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Internal Medicine, Allergy, Nursing, Oncology, Pathology, Pediatrics, Journal, Source Type: news

Average person with atopic dermatitis has no increased risk of actinic keratosis or nonmelanoma skin cancer
People with atopic dermatitis do not appear to be at greater risk for actinic keratosis or basal cell and squamous cell cancer, according to a recent population-based, cross-sectional study. “This is the first study to examine the association between atopic dermatitis and actinic keratosis [AK]....
Source: Skin and Allergy News - February 8, 2016 Category: Dermatology Source Type: news

Allergies and Atopic Dermatitis in Relation to Skin Cancer
Conclusion: Our findings suggest that allergies and atopy may influence risk of early onset BCC and SCC, and that effects may be gender specific. Impact: A deeper understanding of the immune mechanisms underlying allergies and atopy may provide new routes of preventing keratinocyte cancers. Cancer Epidemiol Biomarkers Prev; 24(4); 749–54. ©2015 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - March 31, 2015 Category: Cancer & Oncology Authors: Cheng, J., Zens, M. S., Duell, E., Perry, A. E., Chapman, M. S., Karagas, M. R. Tags: Research Articles Source Type: research

ARRY-502, a potent, selective, oral CRTh2 antagonist reduces Th2 mediators in patients with mild to moderate Th2-driven asthma
Asthma and other allergic diseases are associated with mast cell activation and prostaglandin D2 (PGD2) generation. PGD2 exerts pro-inflammatory activity via chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2). The safety and efficacy of CRTh2 antagonist ARRY-502 was studied in mild atopic asthmatic adults in a double-blind, placebo-controlled 4 week phase 2a study. Enrolled patients were free of inhaled corticosteroids with an FEV1% predicted of 60-85%. Potential participants were screened and randomized to receive 200 mg BID ARRY-502 (n = 93) or matching placebo (n = 91). In patients with elevated...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Wenzel, S., Chantry, D., Eberhardt, C., Hopkins, R., Saunders, M., Anderson, L., Aitchinson, R., Bell, S., Izuhara, K., Ono, J., Burgess, L. Tags: 5.3 Allergy and Immunology Source Type: research

Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation–polyendocrinopathy–enteropathy–X-linked–like syndrome
Conclusions: Gain-of-function mutations in STAT1 can cause an IPEX-like phenotype with normal frequency and function of Treg cells.
Source: Journal of Allergy and Clinical Immunology - March 26, 2013 Category: Allergy & Immunology Authors: Gulbu Uzel, Elizabeth P. Sampaio, Monica G. Lawrence, Amy P. Hsu, Mary Hackett, Morna J. Dorsey, Richard J. Noel, James W. Verbsky, Alexandra F. Freeman, Erin Janssen, Francisco A. Bonilla, Joseph Pechacek, Prabha Chandrasekaran, Sarah K. Browne, Anahita Tags: Immune deficiencies, infection, and systemic immune disorders Source Type: research