Filtered By:
Cancer: Melanoma
Procedure: Transplants
This page shows you your search results in order of date.
Order by Relevance | Date
Total 784 results found since Jan 2013.
Second primary malignancies in patients with lymphoma in Denmark after high-dose chemotherapy and autologous haematopoietic stem-cell transplantation: a population-based, retrospective cohort study
Lancet Haematol. 2023 Sep 6:S2352-3026(23)00212-0. doi: 10.1016/S2352-3026(23)00212-0. Online ahead of print.ABSTRACTBACKGROUND: Second primary malignancies (SPMs) are known complications after chemotherapy, but the risk is not well characterised for patients with lymphoma treated with high-dose chemotherapy and autologous haematopoietic stem-cell transplantation (HSCT). We aimed to investigate the rate of SPMs in this population relative to matched control individuals from the general population.METHODS: In this retrospective, population-based cohort study, patients aged 18 years or older with an aggressive lymphoma who r...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Trine Trab Joachim Baech Lasse Hjort Jakobsen Simon Husby Marianne Tang Severinsen Sandra Eloranta Jette S G ørløv Judit M J ørgensen Sif Gudbrandsdottir Thomas Stauffer Larsen Peter Brown Kirsten Gr ønbæk Karin E Smedby Tarec C El-Galaly Source Type: research
Multiple Administration Routes, Including Intramuscular Injection, of Oncolytic Tanapoxvirus Variants Significantly Regress Human Melanoma Xenografts in BALB/c Nude Mice Reconstituted with Splenocytes from Normal BALB/c Donors
In this study, TPV/Δ66R/mIL-2 and TPV/Δ2L/Δ66R/FliC were tested for their ability to treat human melanoma xenografts (SK-MEL3) in a BALB/c nude mouse model reconstituted with splenocytes from genetically compatible, normal BALB/c donor mice. Two SK-MEL3 tumors were transplanted into each flank of BALB/c nude mice, and the larger tumor was treated intratumorally (IT) with virus or mock injection. In one set of animals, mice received adoptive transfers of splenocytes from BALB/c mice on day 4 to reconstitute their immune systems and allow for adaptive immune responses to occur in a xenograft model. Direct IT injection of ...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Michael L Monaco Omer A Idris Grace A Filpi Steven L Kohler Scott D Haller Jeffery E Burr Robert Eversole Karim Essani Source Type: research
METTL3 Promotes the Growth and Invasion of Melanoma Cells by Regulating the lncRNA SNHG3/miR-330-5p Axis
In conclusion, our findings demonstrated that METTL3-mediated m6A modification of lncRNA SNHG3 promoted the growth and invasion of melanoma cells by regulating the miR-330-5p/CNBP axis.PMID:37606168 | DOI:10.1177/09636897231188300
Source: Cell Transplantation - August 22, 2023 Category: Cytology Authors: Shaojun Chu Yulong Li Baojin Wu Guo Rong Qiang Hou Qin Zhou Dexiang Du Yufei Li Source Type: research
Age-dependent modulation of gut microbiome in response to tumor immunomodulation
In this study, we sequentially treated young mice (~8 weeks) and old mice (>18 months) with bilateral melanoma using FUS and calreticulin nanoparticles (CRT-NP) to enhance immunogenic cell death. The combination of CRT-NP and FUS (CFUS) demonstrated greater efficacy in inducing regression of treated and untreated tumors in young mice compared to old mice. The diminished effectiveness in older mice was associated with significant differences in gut microbiome composition, characterized by alterations in bacterial species and splenic immune cells. Specifically, young mice exposed to CFUS exhibited higher abundance of Bact...
Source: Experimental Gerontology - August 12, 2023 Category: Geriatrics Authors: Akansha Singh Harshini Ashar Ashish Ranjan Source Type: research
USP18 enhances the resistance of BRAF-mutated melanoma cells to vemurafenib by stabilizing cGAS expression to induce cell autophagy
This study aims to discern the possible molecular mechanism of the effect of ubiquitin-specific peptidase 18 (USP18) on the resistance to BRAF inhibitor vemurafenib in BRAF V600E mutant melanoma by regulating cyclic GMP-AMP synthase (cGAS). The cancer tissues of BRAF V600E mutant melanoma patients before and after vemurafenib treatment were collected, in which the protein expression of USP18 and cGAS was determined. A BRAF V600E mutant human melanoma cell line (A2058R) resistant to vemurafenib was constructed with its viability, apoptosis, and autophagy detected following overexpression and depletion assays of USP18 and cG...
Source: International Immunopharmacology - July 21, 2023 Category: Allergy & Immunology Authors: Zhou-Rui Ma Qian-Wei Xiong Shi-Zhong Cai Ling-Tao Ding Chao-Hong Yin Hong-Liang Xia Wei Liu Shu Dai Yue Zhang Zhen-Hong Zhu Zhi-Jian Huang Qian Wang Xiang-Ming Yan Source Type: research
Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
In conclusion, the calcineurin inhibitors used after kidney transplantation are associated with a higher risk of skin cancer-both non-melanoma and melanoma-when compared with other immunosuppressive therapies. This finding suggests that careful monitoring for skin lesions in post-transplant patients must be conducted. However, the decision on the kind of immunotherapy used should always be considered on an individual basis for each renal transplant recipient.PMID:37366913 | DOI:10.3390/curroncol30060430
Source: Cancer Control - June 27, 2023 Category: Cancer & Oncology Authors: Aleksandra Kulbat Karolina Richter Tomasz Stefura Marta Ko łodziej-Rzepa Micha ł Kisielewski Tomasz Wojewoda Wojciech M Wysocki Source Type: research
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A novel cell-wall polysaccharide derived from the stipe of Agaricus bisporus inhibits mouse melanoma proliferation and metastasis
Arch Biochem Biophys. 2023 Jun 23:109678. doi: 10.1016/j.abb.2023.109678. Online ahead of print.ABSTRACTMalignant melanoma is an invasive and highly aggressive skin cancer that-if diagnosed-poses a serious threat to the patient's health and life. In this work, a novel purified cell-wall polysaccharide (termed Abwp) was obtained from the discarded stipe of Agaricus bisporus (A. bisporus) and characterized to be a novel homogeneous polysaccharide consisted of a β-(1 → 4)- glucosyl backbone with β-(1 → 2) and (1 → 6)-d-glucosyl side-chains. The anti-melanoma effects of Abwp and its associated mechanisms in mice were t...
Source: Archives of Biochemistry and Biophysics - June 25, 2023 Category: Biochemistry Authors: Qi-Ci Wu Yin-Ying Zhang Yun-Bing Li Gulimiran Alitongbieke Yu Xue Xiu-Min Li Zhi-Chao Lin Jia-Fu Huang Tao Pan Xiao-Ming Pan Jing-Ping You Jin-Mei Lin Yu-Tian Pan Source Type: research
