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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
The combination of PAC-1 and entrectinib for the treatment of metastatic uveal melanoma
This study is an initial demonstration that the combination of PAC-1 and entrectinib may warrant further clinical investigation. Clinical trial registration: Clinical Trials.gov: NCT04589832.PMID:37738028 | DOI:10.1097/CMR.0000000000000927
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Matthew W Boudreau Emily J Tonogai Claire P Schane Min X Xi James H Fischer Jayanthi Vijayakumar Yan Ji Theodore M Tarasow Timothy M Fan Paul J Hergenrother Arkadiusz Z Dudek Source Type: research
Estimating Remaining Life Expectancy in Veterans with Basal Cell Carcinoma Using an Automated Electronic Health Record Scoring System: A Retrospective Cohort Study
Active surveillance may be considered for low-risk basal cell carcinomas (BCC) in patients with limited life expectancy; however, estimates of life expectancy are not readily available. Veterans Health Administration ’s (VHA) Care Assessment Need (CAN) score may address this problem.
Source: Journal of the American Academy of Dermatology - September 22, 2023 Category: Dermatology Authors: Matthew P. Dizon, Eleni Linos, Susan M. Swetter Source Type: research
Needs and Preferences of Patients With Head-neck Cutaneous SCC
Conditions: Cutaneous Squamous Cell Carcinoma; Cutaneous Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma; Squamous Cell Carcinoma of Head and Neck; Squamous Cell Carcinoma of the Head and Neck; Skin Cancer; Patient Satisfaction; High-Risk Cance r; Preference, Patient; Decision Making; Interview Intervention: Other: Regular care with additional administration of a semi-structured interview Sponsor: Maastricht University Medical Center Active, not recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials
The Melanoma Research Foundation to Host the 2023 LA Miles for Melanoma 5K!
The Melanoma Research Foundation (MRF) is thrilled to announce the next event in its annual Miles for Melanoma nationwide 5K program, bringing together local melanoma patients, care partners and survivors. This year we will be hosting our annual L.A. event on Saturday, October 7, 2023, at...
Source: PRWeb: Medical Pharmaceuticals - September 21, 2023 Category: Pharmaceuticals Tags: NPT Source Type: news
Extended duration of treatment using reduced-frequency dosing of anti-PD-1 therapy in patients with advanced melanoma and Merkel cell carcinoma
CONCLUSIONS: ICI administration at RFD can allow extension of treatment duration, while preserving efficacy and reducing logistical and financial burden. RFD approach deserves further exploration in prospective clinical trials.PMID:37733060 | DOI:10.1007/s00262-023-03539-8
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Lisa May Ling Tachiki Daniel S Hippe Karly Williams Silva Evan Thomas Hall William McCamy Dane Fritzsche Andrea Perdue Julia Majovski Thomas Pulliam Daniel A Goldstein Joshua Veatch Joel Ho Paul T Nghiem John A Thompson Shailender Bhatia Source Type: research
Boiling histotripsy induces dendritic cell activation and acquisition of antigen in tumor draining lymph nodes
bioRxiv. 2023 Sep 6:2023.09.02.552844. doi: 10.1101/2023.09.02.552844. Preprint.ABSTRACTBoiling histotripsy (BH), a mechanical focused ultrasound ablation strategy, can elicit intriguing signatures of anti-tumor immunity. However, the influence of BH on dendritic cell function is unknown, compromising our ability to optimally combine BH with immunotherapies to control metastatic disease. Here, by applying BH to B16F10 melanoma expressing a ZsGreen antigen in a monotherapy protocol that elicits abscopal tumor control, we observed a marked increase in antigen acquisition by multiple phagocytic immune cells, including convent...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Eric A Thim Lydia E Petricca F átima Rivera-Escalera Alexander S Mathew Michael R Elliott Timothy N J Bullock Richard J Price Source Type: research
Topical Calcipotriol Plus Imiquimod Immunotherapy for Nonkeratinocyte Skin Cancers
In this study, we demonstrate that topical TSLP cytokine inducers-calcipotriol and retinoic acid-synergize with IMQ to activate CD4+ T-cell immunity against nonkeratinocyte cutaneous malignancies. Topical calcipotriol plus IMQ treatment reduced breast tumor growth compared with calcipotriol or IMQ alone (P < 0.0001). Calcipotriol plus IMQ-mediated tumor suppression was associated with significant infiltration of CD4+ effector T cells in the tumor microenvironment. Notably, topical calcipotriol plus IMQ immunotherapy enabled immune checkpoint blockade therapy to effectively control immunologically cold breast tumors, whi...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Marjan Azin Kenneth H Ngo Jennet Hojanazarova Shadmehr Demehri Source Type: research
Role of tissue markers associated with tumor microenvironment in the progression and immune suppression of oral squamous cell carcinoma
Med Oncol. 2023 Sep 20;40(10):303. doi: 10.1007/s12032-023-02169-5.ABSTRACTHead and neck cancers (HNC) continues to dominate major cancers contributing to mortality worldwide. Squamous cell carcinoma is the major type of HNC. Oral Squamous Cell Carcinoma grouped under HNC is a malignant tumor occurring in the oral cavity. The primary risk factors of OSCC are tobacco, alcohol consumption, etc. This review focuses on modulations, mechanisms, growth and differentiation of oral squamous cell carcinoma. Cancer cell surrounds itself with a group of elements forming a favorable environment known as tumor microenvironment (TME). I...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Suganya Ramalingam Sivaramakrishnan Shantha Susruthan Muralitharan Uma Sudhakar Harikrishnan Thamizhchelvan Venkatachalam Deepa Parvathi Source Type: research
Albendazole induces an anti-tumor effect and potentiates PD-L1 blockade immunotherapy
CONCLUSION: ABZ inhibits melanoma growth and metastasis. Moreover, ABZ synergized with PD-L1 blockade mediates tumor regression.PMID:37730912 | DOI:10.1007/s00432-023-05415-5
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Weinan Zhang Zhiqiang He Fucheng Liang Jie Gong Liuchang Tan Juan Yang Siji Song Luoyingzi Xie Yuangang Lu Source Type: research
A Review on the Antimutagenic and Anticancer Effects of Cysteamine
In conclusion, regarding the high safety profile of cysteamine and the current literature data presented in this article, cysteamine might be considered as an interesting molecule for the prevention and the treatment of cancer. Further clinical studies should be performed to support these data in humans.PMID:37731680 | PMC:PMC10508993 | DOI:10.1155/2023/2419444
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Chun-Man Lee Source Type: research
