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Cancer: Skin Cancer

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Total 49911 results found since Jan 2013.

Understanding Visual Search Patterns of Dermatologists Assessing Pigmented Skin Lesions Before and After Online Training
Abstract The goal of this investigation was to explore the feasibility of characterizing the visual search characteristics of dermatologists evaluating images corresponding to single pigmented skin lesions (PSLs) (close-ups and dermoscopy) as a venue to improve training programs for dermoscopy. Two Board-certified dermatologists and two dermatology residents participated in a phased study. In phase I, they viewed a series of 20 PSL cases ranging from benign nevi to melanoma. The close-up and dermoscopy images of the PSL were evaluated sequentially and rated individually as benign or malignant, while eye position ...
Source: Journal of Digital Imaging - November 7, 2014 Category: Radiology Source Type: research

Bio-guided search of active indole alkaloids from Tabernaemontana catharinensis: Antitumour activity, toxicity in silico and molecular modelling studies.
Abstract Active plant metabolites have been used as prototype drugs. In this context, Tabernaemontana catharinensis (Apocynaceae) has been highlighted because of the presence of active indole alkaloids. Thus, this study aims the bio-guided search of T. catharinensis cytotoxic alkaloids. The chemical composition was identified by high-resolution mass spectrometry, and fractionation was performed by open column and preparative thin-layer chromatography, from plant stems. The enriched fractions were tested in vitro in tumour cells A375 (melanoma cell line) and A549 (adenocarcinomic human alveolar basal epithelial cel...
Source: Bioorganic Chemistry - December 15, 2018 Category: Chemistry Authors: Rosales PF, Marinho FF, Gower A, Chiarello M, Canci B, Roesch-Ely M, Paula FR, Moura S Tags: Bioorg Chem Source Type: research

Education, income and risk of cancer: results from a Norwegian registry-based study.
CONCLUSION: Our findings were consistent with findings from other studies showing that the incidence rate of cancer differs across levels of socioeconomic status. We may need behavioral change campaigns focused on lifestyle changes that lower the risk of cancer and target perhaps to those with lower socioeconomic status. PMID: 32924698 [PubMed - as supplied by publisher]
Source: Acta Oncologica - September 13, 2020 Category: Cancer & Oncology Authors: Larsen IK, Myklebust TÅ, Babigumira R, Vinberg E, Møller B, Ursin G Tags: Acta Oncol Source Type: research

The family lifestyles, actions and risk education (FLARE) study: Protocol for a randomized controlled trial of a sun protection intervention for children of melanoma survivors
CONCLUSION: The FLARE trial addresses the need for melanoma preventive interventions for children with familial risk for the disease. If efficacious, FLARE could help to mitigate familial risk for melanoma among these children by teaching practices which, if enacted, decrease sunburn occurrence and improve children's use of well-established sun protection strategies.PMID:37393004 | DOI:10.1016/j.cct.2023.107276
Source: Cancer Control - July 1, 2023 Category: Cancer & Oncology Authors: Yelena P Wu Tammy K Stump Jennifer L Hay Lisa G Aspinwall Kenneth M Boucher Pascal R Deboeck Douglas Grossman Kathi Mooney Sancy A Leachman Ken R Smith Ali P Wankier Hannah L Brady Samuel E Hancock Bridget G Parsons Kenneth P Tercyak Source Type: research

Could the 'triple whammy' technique that beat HIV/Aids win battle against cancer?
New gene treatments that attack tumours on multiple fronts can prolong life – but also show cancer cells are more complex than scientists had thoughtWing commander Brian Liversidge was 60 when he was diagnosed, in 2004, as having aggressive prostate cancer. The CEO of a Cumbria educational trust was given 18 months to live.Liversidge – who is married with two sons and three grandsons – has since confounded that grim prediction thanks to a sequence of remarkable medical developments that have kept him alive and which raise hopes it may soon become possible to treat many cancers as manageable chronic conditions.However...
Source: Guardian Unlimited Science - August 24, 2013 Category: Science Authors: Robin McKie Tags: News Medical research Society Higher education Cancer UK news Institute of Cancer Research The Observer Prostate cancer Science Source Type: news

Effect of appearance-based education compared with health-based education on sunscreen use and knowledge: A randomized controlled trial
Background: Appearance-based education shows promise in promoting sunscreen use although resource-intensive methods used in prior studies preclude wide dissemination. Appearance-based video education can be made easily accessible.Objective: We sought to compare the effectiveness of appearance-based video education with that of health-based video education in improving sunscreen use and knowledge.Design: In a randomized controlled trial, participants viewed either an appearance-based video on ultraviolet-induced premature aging or a health-based video emphasizing ultraviolet exposure and skin cancer risk.Results: Fifty high...
Source: Journal of the American Academy of Dermatology - February 7, 2014 Category: Dermatology Authors: William Tuong, April W. Armstrong Tags: Original Articles Source Type: research

The implantation of cervical neoplasia at postpartum episiotomy scar: the clinical evidence
Conclusion Clinicians should be aware about the importance of carefully examining not only the cervix at the time of labor, but also the episiotomy scar in women following a pregnancy complicated by cervical cancer.
Source: Irish Journal of Medical Science - October 7, 2014 Category: Journals (General) Source Type: research

Accuracy and reliability of naevus self-counts
A high number of melanocytic naevi is one of the major risk factors for cutaneous melanoma. Therefore, counting the number of acquired naevi could be a useful strategy to identify individuals at an increased risk for targeted skin cancer screening. The aim of this study was to assess agreement between naevus self-counts and counts of trained examiners as well as to analyse potential determinants of the magnitude of agreement. In a large cross-sectional survey (n=1772), university students counted their naevi on both arms and were additionally examined by specifically trained examiners in a mutually blinded manner. Further ...
Source: Melanoma Research - November 12, 2014 Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Epidemiological research Source Type: research

Human blood plasma proteome mapping for search of potential markers of the lung squamous cell carcinoma.
Authors: Shevchenko VE, Kovalev SV, Arnotskaya NE, Zborovskaya IB, Akhmedov BB, Polotskii BE, Kostin AU, Moukeria AF, Zaridze DG, Davidov MI Abstract Blood plasma proteomes obtained from 77 lung squamous cell carcinoma (LSCC) patients (Stages I-III) and 67 healthy controls (all males) were analyzed by using the label-free liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the search of potential cancer biomarkers. All plasma samples were depleted of 14 highly-abundant plasma proteins by immune-affinity column chromatography before LC-MS/MS. We identified and quantified 809 differential proteins wi...
Source: European Journal of Mass Spectrometry - December 1, 2014 Category: Chemistry Tags: Eur J Mass Spectrom (Chichester, Eng) Source Type: research

Prospective study of the influence of psychological and medical factors on quality of life and severity of symptoms among patients with oral squamous cell carcinoma
Publication date: Available online 17 February 2015 Source:British Journal of Oral and Maxillofacial Surgery Author(s): M. Rana , A. Kanatas , P.Y. Herzberg , M. Khoschdell , H. Kokemueller , N.-C. Gellrich , M. Rana About 400,000 people worldwide are diagnosed with oral squamous cell carcinoma (SCC) annually, and the incidence is increasing. Many advanced carcinomas of the oral cavity require radical surgical treatment that can impair patient's quality of life (QoL) and severity of symptoms. We therefore aimed to identify coping strategies and disease-specific medical factors that affect QoL and severity of symptoms. Pa...
Source: British Journal of Oral and Maxillofacial Surgery - February 18, 2015 Category: ENT & OMF Source Type: research

Seeking Health Information Online: Association With Young Australian Women’s Physical, Mental, and Reproductive Health
Conclusions: Women experiencing “stigmatized” conditions or symptoms were more likely to search the Internet for health information. The Internet may be an acceptable resource that offers “anonymized” information or support to young women and this has important implications for health service providers and public health policy.
Source: Journal of Medical Internet Research - May 18, 2015 Category: Journals (General) Authors: Ingrid Jean RowlandsDeborah LoxtonAnnette DobsonGita Devi Mishra Source Type: research

Google Search Trends and Skin Cancer
Whether there is an association between population inquisitiveness in skin cancer and melanoma incidence, mortality, and the mortality to incidence ratio is unknown. Google Trends quantifies interest in topics at the population level by analyzing all search queries for a specific term, thus serving as an increasingly useful research tool. Search volume indexes (SVIs) are normalized values based on total searches during a specified period per selected region. We decided to use this innovative tool to evaluate whether population inquisitiveness on melanoma and skin cancer was correlated with a lower incidence, mortality, and...
Source: JAMA Dermatology - June 10, 2015 Category: Dermatology Source Type: research

The search for cis-regulatory driver mutations in cancer genomes.
Authors: Poulos RC, Sloane MA, Hesson LB, Wong JW Abstract With the advent of high-throughput and relatively inexpensive whole-genome sequencing technology, the focus of cancer research has begun to shift toward analyses of somatic mutations in non-coding cis-regulatory elements of the cancer genome. Cis-regulatory elements play an important role in gene regulation, with mutations in these elements potentially resulting in changes to the expression of linked genes. The recent discoveries of recurrent TERT promoter mutations in melanoma, and recurrent mutations that create a super-enhancer regulating TAL1 expression...
Source: Oncotarget - September 13, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Adrian Grant obituary
My husband, Adrian Grant, who has died aged 67 of ocular melanoma, had a distinguished career as an epidemiologist.Initially an obstetrician, he was inspired by a course in medical demography in 1979 to join the newly created National Perinatal Epidemiology Unit in Oxford, under the charismatic Iain Chalmers. There Adrian established the Perinatal Trials Service with Diana Elbourne, who later became professor of healthcare evaluation at the London School of Hygiene and Tropical Medicine. Together they pioneered the most productive international perinatal trials research initiative in the world, enabling mothers, midwives a...
Source: Guardian Unlimited Science - November 2, 2015 Category: Science Authors: Frances Grant Tags: Medical research Science Health Society University of Aberdeen Higher education Source Type: news