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Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Exposome and Skin: Part 1. Bibliometric Analysis and Review of the Impact of Exposome Approaches on Dermatology
ConclusionsExposome studies are rapidly attracting interest in dermatology. The results of these studies will undoubtedly improve our understanding of why and under which circumstances some individuals develop skin disorders and help design tailored prevention strategies for patients suffering from these disorders.
Source: Dermatology and Therapy - February 3, 2022 Category: Dermatology Source Type: research

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Association of atopy and tentative diagnosis of skin cancer – results from occupational skin cancer screenings
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship between atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.
Source: Journal of the European Academy of Dermatology and Venereology - August 3, 2017 Category: Dermatology Authors: I. Sch äfer, P. Mohr, N. Zander, R. Fölster‐Holst, M. Augustin Tags: Original Article Source Type: research

Association of atopy and tentative diagnosis of skin cancer ‐ results from occupational skin cancer screenings
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship of atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - July 6, 2017 Category: Dermatology Authors: I. Sch äfer, P. Mohr, N. Zander, R. Fölster‐Holst, M. Augustin Tags: Original Article Source Type: research

Allergies and Atopic Dermatitis in Relation to Skin Cancer
Conclusion: Our findings suggest that allergies and atopy may influence risk of early onset BCC and SCC, and that effects may be gender specific. Impact: A deeper understanding of the immune mechanisms underlying allergies and atopy may provide new routes of preventing keratinocyte cancers. Cancer Epidemiol Biomarkers Prev; 24(4); 749–54. ©2015 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - March 31, 2015 Category: Cancer & Oncology Authors: Cheng, J., Zens, M. S., Duell, E., Perry, A. E., Chapman, M. S., Karagas, M. R. Tags: Research Articles Source Type: research

Equine Dermatology
The last issue of Veterinary Clinics of North America: Equine Practice dedicated to dermatology was published in 1995. At that time, there were relatively few literature resources dedicated to the dermatologic diseases of horses. Since then, interest and expertise in equine dermatology has continued to grow. There are now several textbooks that provide excellent coverage of what has become a very lengthy list of equine dermatologic diseases. In this issue, we have not chosen to re-create a “mini” textbook. We have instead chosen to highlight a number of diseases or clinical presentations that we feel are clinically rel...
Source: Veterinary Clinics of North America: Equine Practice - October 28, 2013 Category: Veterinary Research Authors: Anthony A. Yu, Rod A.W. Rosychuk Source Type: research