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Rates of Influenza and Pneumococcal Vaccination and Correlation With Survival in Multiple Myeloma Patients
CONCLUSION: Vaccination is important in MM and should be encouraged. Vaccination status should be recorded in prospective clinical trials as it may affect survival. This trial was registered at www.CLINICALTRIALS: gov as #NCT02761187.PMID:36641358 | DOI:10.1016/j.clml.2022.12.003
Source: Clinical Lymphoma and Myeloma - January 14, 2023 Category: Cancer & Oncology Authors: Michael A Thompson Mario Boccadoro Xavier Leleu Jorge Vela-Ojeda Frits van Rhee Katja C Weisel Robert M Rifkin Saad Z Usmani Roman H ájek Gordon Cook Rafat Abonour Mira Armour Kathryn E Morgan Su-Peng Yeh Caitlin L Costello Jesus G Berdeja Faith E Davies Source Type: research

Vaccination efficacy in patients with chronic lymphocytic leukemia
Leuk Lymphoma. 2022 Oct 21:1-15. doi: 10.1080/10428194.2022.2133538. Online ahead of print.ABSTRACTChronic lymphocytic leukemia (CLL) is a disorder of mature malignant B cells with multiple elements of immune dysfunction. Infections are common in CLL patients due to complex immunodeficiency. Vaccines are used as preventative measures for common diseases including influenza, pneumococcus, tetanus/diphtheria and shingles in the general population. Vaccines are utilized to mitigate this risk, although there have been some concerns regarding the efficacy of vaccines in the CLL population due to the inherent complex immune dysf...
Source: Herpes - October 21, 2022 Category: Infectious Diseases Authors: Kevin Y Wang Pratik Shah Brandon Skavla Fatima Fayaaz Jeffrey Chi Joanna M Rhodes Source Type: research

Vaccination coverage in hematological patients undergoing chemotherapy: Should we move towards personalized vaccination?
CONCLUSION: Despite vaccination opportunities, the complexity of these specific recommendations and the lack of communication between the health actors could explain the suboptimal vaccination coverage in this high-risk population. A proactive attitude of all actors in the city and hospital, including better patient information and a personalized and evolving vaccination schedule to help GPs to coordinate vaccination would allow to improve vaccine coverage.PMID:34740475 | DOI:10.1016/j.vaccine.2021.10.040
Source: Vaccine - November 6, 2021 Category: Allergy & Immunology Authors: Alix Pierron Fabienne Bozon Ana Berceanu Jean Fontan Annie Brion Erick Deconinck Catherine Chirouze Anne-Sophie Brunel Source Type: research

The management of hematologic malignancies during the COVID-19 pandemic.
Authors: Hus I, Salomon-Perzyński A, Tomasiewicz K, Robak T Abstract Introduction: Patients with hematological malignancies have experienced a more severe clinical course of COVID-19 and higher mortality than those with solid tumors and those without cancer. The ongoing pandemic poses many challenges in assuring the correct and timely diagnosis of hemato-oncology patients as well as the optimal treatment. Areas covered: The present paper reviews current data on the incidence and clinical course of COVID-19 in patients with hematological malignancies. A literature review of the MEDLINE database for articles was con...
Source: Expert Opinion on Pharmacotherapy - December 22, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

How Scientists Are Treating Breast Cancer Using the Immune System
As a pharmacist, Kathy James considers herself well educated about the importance of getting regular cancer screenings. Even though the 55-year-old had no history of cancer in her family, she never skipped her regular mammograms, and she gave herself regular breast exams. So she was dumbfounded when, during one of those self-exams in May 2017, she felt a marble-size lump in her left breast. A visit to the doctor confirmed it. “The radiologist came in with his hands in his pockets and looked down and said, ‘It doesn’t look good,'” James says. After a biopsy, James and her husband learned she had meta...
Source: TIME: Health - October 4, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized breast cancer news Frontiers of Medicine Source Type: news

Evans Syndrome Presented with Marginal Zone Lymphoma and Duodenal Neuroendocrine Tumor in an Elderly Woman
We report a case of ES in an elderly patient in the presence of multiple trigger factors such as recent influenza vaccine, marginal zone lymphoma, and neuroendocrine tumor G1. Whether this association is casual or causal remains a matter of speculation. It is however necessary to have a thorough work-up in a newly diagnosed ES and a more accurate search of miscellaneous factors especially in elderly patients.
Source: International Journal of Gerontology - October 12, 2014 Category: Geriatrics Source Type: research

Can Gingko and Turmeric Help Stop Ebola?
Summary There is no known pharmaceutical currently available that specifically treats Ebola disease. One treatment modality that should be considered is the use of herbal medicines, which have both centuries old anecdotal success as well as recent modern biochemical and formal research rationales for their use. Five areas of action that could be addressed by the herbal medicines as it relates to Ebola would be: VP24/immune system evasion GP protein/replicatio; herbal strategies effective against similar hemorrhagic disease beneficial modulation of patient immune and inflammatory response systems prophylactic use for heal...
Source: Inside Surgery - August 1, 2014 Category: Surgery Authors: Editor Tags: Infectious Disease ayurvedic baicalen cathepsin b dengue Ebola gingko herb Quercetin resveratrol rosemary sage st johns work turmeric Source Type: blogs