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Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
CONCLUSION Pediatric patients with SARS–CoV-2 are at risk for critical illness with severe COVID-19 and MIS-C. Cytokine profiling and examination of peripheral blood smears may distinguish between patients with MIS-C and those with severe COVID-19.FUNDING Financial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex’s Lemonade Stand Foundation for Childhood Cancer; Children’s Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Am...
Source: Journal of Clinical Investigation - October 6, 2020 Category: Biomedical Science Authors: Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T Source Type: research

Genetically Engineered T Cells Could Lead to Therapies for Autoimmune Diseases
Digital media& downloads Genetically Engineered T Cells Could Lead to Therapies for Autoimmune Diseases UArizona immunobiologists have created a five-module chimeric antigen receptor T cell that is showing early potential to fight Type 1 diabetes. Stacy Pigott Today University of Arizona Health SciencesNHG-111220-KUHNS-LAB_DSC9160-web.jpg Michael Kuhns, associate professor in the Department of Immunobiology, and Shio Kobayashi, a post-doctoral research fellow, study the basic science of T cell activation in the immune system, and they are using that knowledge to find potential therapies for autoimmune diseases. ...
Source: The University of Arizona: Health - December 4, 2020 Category: Universities & Medical Training Authors: mittank Source Type: research

ALL-079 Association of T-Cell Receptor Repertoire Diversity With L-Asparaginase Hypersensitivity in Childhood Acute Lymphoblastic Leukemia
Context: Asparaginase is an indispensable component of therapy for childhood acute lymphoblastic leukemia (ALL) but is very commonly associated with allergy which causes morbidity and poorer outcomes. The exact aspects of T-cell immunity underpinning association with asparaginase allergy has yet to be characterized. Objective: To evaluate the associations of T-cell receptor (TCR) repertoire and its diversity with asparaginase hypersensitivity in children with ALL. Design: Longitudinal TCR-sequencing of 180 bone marrow samples across 3 time-points (diagnosis, post-induction, post-consolidation) from 67 children with ALL tre...
Source: Clinical Lymphoma, Myeloma and Leukemia - September 21, 2022 Category: Hematology Authors: Shawn HR Lee, Zhenhua Li, Evelyn HZ Lim, Winnie HN Chin, Chiew Kean Hui, Chen Zhi Wei, Bernice LZ Oh, Ah Moy Tan, Hany Ariffin, Jun J Yang, Allen EJ Yeoh Tags: Acute Lymphoblastic Leukemia Source Type: research

Low-grade B-cell lymphoma presenting as a uvular mass.
Abstract Uvular enlargement may occur acutely as a result of infection, allergy, or trauma. Squamous cell carcinoma may present as a progressively enlarging uvular mass. Primary MALT (mucosa-associated lymphoid tissue) lymphoma of the uvula and a neuroendocrine tumor of the parapharyngeal space presenting as a uvular mass have each been previously described in the literature. Here we present a case of low-grade B-cell lymphoma presenting as a uvular mass in a 55-year-old patient with progressive throat swelling and dysphagia. PMID: 23288827 [PubMed - in process]
Source: Ear, Nose and Throat Journal - December 1, 2012 Category: ENT & OMF Authors: Walker R, Heffelfinger R Tags: Ear Nose Throat J Source Type: research

The antihistamines clemastine and desloratadine inhibit STAT3 and c‐Myc activities and induce apoptosis in cutaneous T‐cell lymphoma cell lines
Abstract Mycosis fungoides and its leukemic counterpart Sézary syndrome are the most frequent cutaneous T‐cell lymphomas (CTCL), and there is no cure for these diseases. We evaluated the effect of clinically approved antihistamines on the growth of CTCL cell lines. CTCL cell lines as wells as blood lymphocytes from patients with Sézary syndrome were cultured with antihistamines and the cell were analysed for proliferation, apoptosis and expression of programmed death molecules and transcription factors. The two antihistamines clemastine and desloratadine, currently used for symptom alleviation in allergy, induced poten...
Source: Experimental Dermatology - January 1, 2013 Category: Dermatology Authors: Udo Döbbeling, Ying Waeckerle‐Men, Franziska Zabel, Nicole Graf, Thomas M. Kündig, Pål Johansen Tags: Regular Article Source Type: research

The cost effectiveness of treating paediatric cancer in low-income and middle-income countries: a case-study approach using acute lymphocytic leukaemia in Brazil and Burkitt lymphoma in Malawi
The objective of the present work was to determine cost-effectiveness thresholds for common paediatric cancers using acute lymphoblastic leukaemia (ALL) in Brazil and Burkitt lymphoma (BL) in Malawi as examples. Disability-adjusted life years (DALYs) prevented by treatment were compared to the gross domestic product (GDP) per capita of each country to define cost-effectiveness thresholds using WHO-CHOICE (‘CHOosing Interventions that are Cost-Effective’) guidelines. The case examples were selected due to the data available and because ALL and BL both have the potential to yield significant health gains at a low...
Source: Archives of Disease in Childhood - January 15, 2013 Category: Pediatrics Authors: Bhakta, N., Martiniuk, A. L. C., Gupta, S., Howard, S. C. Tags: Oncology, Health policy, Immunology (including allergy), Child health, Health economics, Health service research Global child health Source Type: research

How to use Helicobacter pylori testing in paediatric practice
Introduction Helicobacter pylori is a slowly growing, gram negative microaerophilic bacterium that colonises the gastric mucosa. Cross-sectional epidemiological studies from both developed and developing countries suggest that the prevalence of H. pylori infection worldwide is declining, and may even be less than 10% in ‘westernised’ countries.1 2 H. pylori infection is acquired during the first decade of life and infection usually persists without treatment. Spontaneous clearance has been reported, although co-incidental antibiotic exposure may influence such ‘clearance’. H. pylori is the causative...
Source: Archives of Disease in Childhood - Education and Practice - January 16, 2013 Category: Pediatrics Authors: Crowley, E., Bourke, B., Hussey, S. Tags: Oncology, Surgery, Stomach and duodenum, Immunology (including allergy), Drugs: infectious diseases, Pain (neurology), Childhood nutrition, Childhood nutrition (paediatrics), Surgical diagnostic tests, Screening (epidemiology), Screening (public health) Source Type: research

Combined DOCK8 and CLEC7A mutations causing immunodeficiency in 3 brothers with diarrhea, eczema, and infections
We report 4 brothers from a consanguineous Italian family with an immunodeficiency syndrome characterized by severe eczema, milk and egg allergies, recurrent infections, intractable diarrhea, failure to thrive, and, in 2 of the 3 surviving brothers, lymphoma. One of the brothers (patient II-2) died at age 12 months of cardiovascular failure caused by intractable diarrhea, and the other 3 were evaluated as part of this study ( and , A). The proband (patient II-1) presented shortly after birth with severe eczema and intractable diarrhea without gastrointestinal infection. In the first year of life, he had multiple allergies ...
Source: Journal of Allergy and Clinical Immunology - February 1, 2013 Category: Allergy & Immunology Authors: Darrell L. Dinwiddie, Stephen F. Kingsmore, Sonia Caracciolo, Giuseppe Rossi, Daniele Moratto, Cinzia Mazza, Cristiano Sabelli, Rosa Bacchetta, Laura Passerini, Chiara Magri, Callum J. Bell, Neil A. Miller, Shannon L. Hateley, Carol J. Saunders, Lu Zhang, Tags: Letters to the Editor Source Type: research

MicroRNAs are suitable for assessment as biomarkers from formalin-fixed paraffin-embedded tissue, and miR-24 represents an appropriate reference microRNA for diffuse large B-cell lymphoma studies
In this study, we show that microRNA expression is comparable between FFPET and matched fresh-frozen samples (miR-17-5p: p=0.01, miR-92: p=0.003), and demonstrate that no significant deterioration in expression occurs over prolonged FFPET storage (p=0.06). Furthermore, microRNA expression is equivalent dependant on RNA extraction method (p<0.001) or DNAse treatment of total RNA (p<0.001). Finally, we validate miR-24 as a suitable reference microRNA for diffuse large B-cell lymphoma (DLBCL) FFPET studies.
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Culpin, R. E., Sieniawski, M., Proctor, S. J., Menon, G., Mainou-Fowler, T. Tags: Molecular genetics, Immunology (including allergy), Clinical diagnostic tests Short report Source Type: research

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease
Conclusions Analysis of adverse events of interest through nearly 12 years of adalimumab exposure in clinical trials across indications demonstrated individual differences in rates by disease populations, no new safety signals and a safety profile consistent with known information about the anti-TNF class.
Source: Annals of the Rheumatic Diseases - February 25, 2013 Category: Rheumatology Authors: Burmester, G. R., Panaccione, R., Gordon, K. B., McIlraith, M. J., Lacerda, A. P. M. Tags: Inflammatory bowel disease, Open access, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological resear Source Type: research

Epstein-Barr virus–independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency
We report on one of the first patients, 411BR, who carried a homozygous 833G>A/R278H mutation and 2 cooperating homozygous N-terminal single nucleotide polymorphisms. Despite remaining well for many years, albeit with profound learning difficulties, persistent anemia, thrombocytopenia and lymphopenia, bronchiectasis, and combined immunodeficiency treated with immunoglobulin replacement (see in this article's Online Repository at www.jacionline.org), he re-presented at 23 years of age with rapidly enlarging cervical lymphadenopathy. EBV was negative in blood by PCR. Biopsy revealed diffuse large B-cell lymphoma (DLBCL). Com...
Source: Journal of Allergy and Clinical Immunology - December 10, 2012 Category: Allergy & Immunology Authors: Chris M. Bacon, Sarah J. Wilkinson, Gavin P. Spickett, Dawn Barge, Helen H. Lucraft, Graham Jackson, Vikki Rand, Andrew R. Gennery Tags: Letters to the Editor Source Type: research

Prognostic impact of concordant and discordant cytomorphology of bone marrow involvement in patients with diffuse, large, B-cell lymphoma treated with R-CHOP
Conclusions Prognostication based on bone marrow involvement cytomorphology is a useful indicator of progression-free survival and overall survival, independent of the International Prognostic Index score, in DLBCL patients. Accurate staging based on morphology should thus be included in bone marrow examinations of such cases.
Source: Journal of Clinical Pathology - April 21, 2013 Category: Pathology Authors: Shim, H., Oh, J.-I., Park, S. H., Jang, S., Park, C.-J., Huh, J., Suh, C., Chi, H.-S. Tags: Immunology (including allergy), Clinical diagnostic tests Original article Source Type: research

Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - May 14, 2013 Category: Allergy & Immunology Authors: Leonardo Vargas, Abdulrahman Hamasy, Beston F. Nore, C. I.Edvard Smith Tags: Review Source Type: research

Use of immunohistochemistry in the diagnosis of problematic breast lesions
This article reviews the common uses of immunohistochemistry in diagnostic breast pathology. It is important to be aware of the limitations of individual antibodies. Such problems can often be overcome by using panels of antibodies. Quality control is also essential: internal and external controls should show appropriate staining. Immunohistochemistry must be interpreted in combination with the morphology seen on H&E sections. Myoepithelial markers, such as smooth muscle actin, smooth muscle myosin heavy chain and p63, are useful for distinguishing invasive carcinoma from sclerosing lesions and ductal carcinoma in situ...
Source: Journal of Clinical Pathology - May 22, 2013 Category: Pathology Authors: Lee, A. H. S. Tags: Immunology (including allergy), Breast cancer, Skin cancer, Gynecological cancer, Lung cancer (oncology), Lung cancer (respiratory medicine), Dermatology Review Source Type: research