ALL-079 Association of T-Cell Receptor Repertoire Diversity With L-Asparaginase Hypersensitivity in Childhood Acute Lymphoblastic Leukemia

Context: Asparaginase is an indispensable component of therapy for childhood acute lymphoblastic leukemia (ALL) but is very commonly associated with allergy which causes morbidity and poorer outcomes. The exact aspects of T-cell immunity underpinning association with asparaginase allergy has yet to be characterized. Objective: To evaluate the associations of T-cell receptor (TCR) repertoire and its diversity with asparaginase hypersensitivity in children with ALL. Design: Longitudinal TCR-sequencing of 180 bone marrow samples across 3 time-points (diagnosis, post-induction, post-consolidation) from 67 children with ALL treated on the frontline Ma-Spore ALL 2010 trial.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 21, 2022 Category: Hematology Authors: Shawn HR Lee, Zhenhua Li, Evelyn HZ Lim, Winnie HN Chin, Chiew Kean Hui, Chen Zhi Wei, Bernice LZ Oh, Ah Moy Tan, Hany Ariffin, Jun J Yang, Allen EJ Yeoh Tags: Acute Lymphoblastic Leukemia Source Type: research