• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma
AbstractThe transcription factor STAT6 (Signal Transducer and Activator of Transcription 6) is a key regulator of Th2 (T-helper 2) mediated allergic inflammation via the IL-4 (interleukin-4) JAK (Janus kinase)/STAT signalling pathway. We identified a novel heterozygous germline mutationSTAT6 c.1255G  >  C, p.D419H leading to overactivity of IL-4 JAK/STAT signalling pathway, in a kindred affected by early-onset atopic dermatitis, food allergy, eosinophilic asthma, anaphylaxis and follicular lymphoma. STAT6 D419H expression and functional activity were compared with wild type STAT6 in transduced H EK293T cells and to ...
Source: Journal of Clinical Immunology - June 14, 2023 Category: Allergy & Immunology Source Type: research

M049 brentuximab desensitization after severe anaphylaxis in a patient with refractory hodgkin's lymphoma
Brentuximab is an antibody-drug conjugate that was developed by linking the antiCD30 antibody cAC10 with the antitubulin chemotherapeutic compound monomethyl auristatin-E, results in 75% in refractory Hodgkin ’s lymphoma.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: R. Villarreal Gonzalez, S. Gonzalez-Diaz, C. De Lira-Quezada Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

“Rituximab hypersensitivity and desensitization: A personalized approach to treat cancer and connective tissue diseases”
Rituximab is a chimeric monoclonal anti-CD20 antibody with wide use in cancer (lymphoma) and connective tissue diseases (rheumatoid arthritis, and vasculitis)1. Hypersensitivity reactions to rituximab can range from type I IgE-mediated reaction (urticaria, shortness of breath, hypotension, or anaphylaxis), to cytokine-mediated reaction (fevers, chills, rigors), or a mix of both, thus limiting the use of rituximab as first line therapy for many cases. Desensitization is a new therapeutic approach which can be performed with rituximab to offset these reactions.
Source: Annals of Allergy, Asthma and Immunology - March 14, 2019 Category: Allergy & Immunology Authors: Barbara C. Yang, Mariana C. Castells Tags: Challenging Clinical Cases Source Type: research

Rituximab hypersensitivity and desensitization
Rituximab is a chimeric monoclonal anti-CD20 antibody with wide use in cancer (lymphoma) and connective tissue diseases (rheumatoid arthritis and vasculitis).1 Hypersensitivity reactions to rituximab can range from type I immunoglobulin E (IgE)-mediated reaction (urticaria, shortness of breath, hypotension, or anaphylaxis) to cytokine-mediated reaction (fevers, chills, rigors) or a mix of both, thus limiting the use of rituximab as first-line therapy for many cases. Desensitization is a new therapeutic approach that can be performed with rituximab to offset these reactions.
Source: Annals of Allergy, Asthma and Immunology - March 14, 2019 Category: Allergy & Immunology Authors: Barbara C. Yang, Mariana C. Castells Tags: Challenging Clinical Cases Source Type: research

Ibrutinib, a Bruton ’s tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity
Approximately 15 million people, including 8% of children, in the United States have food allergy and are at risk of having life-threatening anaphylactic reactions.1 There is an unmet need for the prevention of such reactions. Tyrosine kinases, including Bruton's tyrosine kinase (BTK), have been shown to be critical for allergen reactivity by transducing Fc εRI crosslinking signals into cellular activation and mediator release from mast cells and basophils.2 Pharmacyclics, Inc, together with Janssen Pharmaceuticals, recently received Food and Drug Administration approval of ibrutinib (Imbruvica, PCI-32765) as a selective,...
Source: Journal of Allergy and Clinical Immunology - April 4, 2017 Category: Allergy & Immunology Authors: Jennifer A. Regan, Yun Cao, Melanie C. Dispenza, Shuo Ma, Leo I. Gordon, Adam M. Petrich, Bruce S. Bochner Tags: Letter to the Editor Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies
Abstract Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients’ survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A, IgE, ...
Source: Clinical Reviews in Allergy and Immunology - June 7, 2016 Category: Allergy & Immunology Source Type: research

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies.
Abstract Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A, IgE, an...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Bonamichi-Santos R, Castells M Tags: Clin Rev Allergy Immunol Source Type: research

Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions
Conclusions: Our results indicated that downregulated BCL2L10 caused by miR-18a-5p overexpression mediates intrinsic keratinocyte apoptosis in patients with TEN. Serum miR-18a-5p levels can be a useful disease marker for drug eruptions.
Source: Journal of Allergy and Clinical Immunology - November 4, 2013 Category: Allergy & Immunology Authors: Asako Ichihara, Zhongzhi Wang, Masatoshi Jinnin, Yuki Izuno, Naoki Shimozono, Keitaro Yamane, Akihiko Fujisawa, Chikako Moriya, Satoshi Fukushima, Yuji Inoue, Hironobu Ihn Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research